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dc.creatorAvramov-Ivić, Milka
dc.creatorPetrović, Slobodan
dc.creatorMijin, Dušan
dc.creatorVanmoos, F.
dc.creatorOrlović, D. Z.
dc.creatorMarjanović, D. Z.
dc.creatorRadović, V. V.
dc.date.accessioned2021-03-10T10:54:54Z
dc.date.available2021-03-10T10:54:54Z
dc.date.issued2008
dc.identifier.issn0013-4686
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/1271
dc.description.abstractThe reactivity of erythromycin (pure) was investigated on a gold electrode in neutral electrolyte by cyclic voltammetry. The resulting structural changes were observed with HPLC and FTIR spectroscopy by analyzing the bulk electrolyte after the electrochemical reactions. The results were compared with those previously obtained for azithromycin and clarithromycin under the same experimental conditions. It was found that the electrochemical behavior of erythromycin A differs from that of azithromycin dihydrate. Comparison with the electrochemical activity of basic clarithromycin suggests that the electrochemical activity of erythromycin is similar but more pronounced than that of clarithromycin. HPLC analysis confirmed these observations and showed that during the electrochemical oxidation of erythromycin A, the amount of starting macrolide decreased while the amount of starting impurities increased. Also some new products were observed. FTIR spectroscopy confirmed that erythromycin A is more reactive than clarithromycin, although similar changes in their molecular structures were observed.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142063/RS//
dc.rightsrestrictedAccess
dc.sourceElectrochimica Acta
dc.subjectErythromycin Aen
dc.subjectGold electrodeen
dc.subjectCyclic voltammetryen
dc.subjectHPLCen
dc.subjectFTIRen
dc.titleThe electrochemical behavior of erythromycin A on a gold electrodeen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage654
dc.citation.issue2
dc.citation.other54(2): 649-654
dc.citation.rankM21
dc.citation.spage649
dc.citation.volume54
dc.identifier.doi10.1016/j.electacta.2008.07.010
dc.identifier.rcubconv_3118
dc.identifier.scopus2-s2.0-53949114226
dc.identifier.wos000263282400075
dc.type.versionpublishedVersion


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