Microbial Polysaccharides and their Derivatives as Current and Prospective Pharmaceuticals
Само за регистроване кориснике
2008
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The ability to produce polysaccharides is widely found among microbial species. The structural diversity of the microbial polysaccharides (MPS) leads to a wide diversity of their applications. This review focuses pharmacological properties of MPS and their derivatives. They have been reported to possess many biological activities, such as antiviral, antitumor, antimicrobial and anticoagulant activities. So, the MPS of the type beta-1,3-D-glucans, including curdlan and scleroglucan, show antitumor and antiviral activity. A number of biological and synthetic sulfated polysaccharides, including sulfated polysaccharides from marine microalgae, inhibit viral infections. Many of MPS demonstrate a series of attractive properties as carrier materials in drug delivery systems and nonviral gene delivery. Furthermore, MPS have found an application as wound-healing agents, blood plasma expanders and vaccines. Some MPS, like chitin, chitosan and alginate have an unusual combination of biological ac...tivities and physicochemical properties leading to the development of novel or improved pharmaceuticals. They have become of a great interest not only as drug and cell carriers but also as new functional materials of high biological activity, and recent progress in MPS chemistry is quite noteworthy. This review also examines the advances in the application of MPS in the field of tissue engineering.
Кључне речи:
Microbial polysaccharides / antiviral activity / antitumor activity / antimicrobial activity / drug delivery systems / blood plasma expanders / vaccines / tissue engineeringИзвор:
Current Pharmaceutical Design, 2008, 14, 29, 3168-3195Издавач:
- Bentham Science Publ Ltd, Sharjah
DOI: 10.2174/138161208786404254
ISSN: 1381-6128
PubMed: 19075698
WoS: 000261915800008
Scopus: 2-s2.0-58849110356
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Šmelcerović, Andrija AU - Knežević-Jugović, Zorica AU - Petronijević, Živomir PY - 2008 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1275 AB - The ability to produce polysaccharides is widely found among microbial species. The structural diversity of the microbial polysaccharides (MPS) leads to a wide diversity of their applications. This review focuses pharmacological properties of MPS and their derivatives. They have been reported to possess many biological activities, such as antiviral, antitumor, antimicrobial and anticoagulant activities. So, the MPS of the type beta-1,3-D-glucans, including curdlan and scleroglucan, show antitumor and antiviral activity. A number of biological and synthetic sulfated polysaccharides, including sulfated polysaccharides from marine microalgae, inhibit viral infections. Many of MPS demonstrate a series of attractive properties as carrier materials in drug delivery systems and nonviral gene delivery. Furthermore, MPS have found an application as wound-healing agents, blood plasma expanders and vaccines. Some MPS, like chitin, chitosan and alginate have an unusual combination of biological activities and physicochemical properties leading to the development of novel or improved pharmaceuticals. They have become of a great interest not only as drug and cell carriers but also as new functional materials of high biological activity, and recent progress in MPS chemistry is quite noteworthy. This review also examines the advances in the application of MPS in the field of tissue engineering. PB - Bentham Science Publ Ltd, Sharjah T2 - Current Pharmaceutical Design T1 - Microbial Polysaccharides and their Derivatives as Current and Prospective Pharmaceuticals EP - 3195 IS - 29 SP - 3168 VL - 14 DO - 10.2174/138161208786404254 ER -
@article{ author = "Šmelcerović, Andrija and Knežević-Jugović, Zorica and Petronijević, Živomir", year = "2008", abstract = "The ability to produce polysaccharides is widely found among microbial species. The structural diversity of the microbial polysaccharides (MPS) leads to a wide diversity of their applications. This review focuses pharmacological properties of MPS and their derivatives. They have been reported to possess many biological activities, such as antiviral, antitumor, antimicrobial and anticoagulant activities. So, the MPS of the type beta-1,3-D-glucans, including curdlan and scleroglucan, show antitumor and antiviral activity. A number of biological and synthetic sulfated polysaccharides, including sulfated polysaccharides from marine microalgae, inhibit viral infections. Many of MPS demonstrate a series of attractive properties as carrier materials in drug delivery systems and nonviral gene delivery. Furthermore, MPS have found an application as wound-healing agents, blood plasma expanders and vaccines. Some MPS, like chitin, chitosan and alginate have an unusual combination of biological activities and physicochemical properties leading to the development of novel or improved pharmaceuticals. They have become of a great interest not only as drug and cell carriers but also as new functional materials of high biological activity, and recent progress in MPS chemistry is quite noteworthy. This review also examines the advances in the application of MPS in the field of tissue engineering.", publisher = "Bentham Science Publ Ltd, Sharjah", journal = "Current Pharmaceutical Design", title = "Microbial Polysaccharides and their Derivatives as Current and Prospective Pharmaceuticals", pages = "3195-3168", number = "29", volume = "14", doi = "10.2174/138161208786404254" }
Šmelcerović, A., Knežević-Jugović, Z.,& Petronijević, Ž.. (2008). Microbial Polysaccharides and their Derivatives as Current and Prospective Pharmaceuticals. in Current Pharmaceutical Design Bentham Science Publ Ltd, Sharjah., 14(29), 3168-3195. https://doi.org/10.2174/138161208786404254
Šmelcerović A, Knežević-Jugović Z, Petronijević Ž. Microbial Polysaccharides and their Derivatives as Current and Prospective Pharmaceuticals. in Current Pharmaceutical Design. 2008;14(29):3168-3195. doi:10.2174/138161208786404254 .
Šmelcerović, Andrija, Knežević-Jugović, Zorica, Petronijević, Živomir, "Microbial Polysaccharides and their Derivatives as Current and Prospective Pharmaceuticals" in Current Pharmaceutical Design, 14, no. 29 (2008):3168-3195, https://doi.org/10.2174/138161208786404254 . .