TechnoRep - Faculty of Technology and Metallurgy Repository
University of Belgrade - Faculty of Technology and Metallurgy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrillic)
    • Serbian (Latin)
  • Login
View Item 
  •   TechnoRep
  • Tehnološko-metalurški fakultet
  • Radovi istraživača / Researchers’ publications (TMF)
  • View Item
  •   TechnoRep
  • Tehnološko-metalurški fakultet
  • Radovi istraživača / Researchers’ publications (TMF)
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Semi-interpenetrating polymer networks of chitosan and poly(ethylene glycol)

Semi-interpenetrirajuće mreže hitozana i poli(etilen glikola)

Thumbnail
2008
0367-598X0806345M.pdf (565.5Kb)
Authors
Milosavljević, Nedeljko
Kalagasidis Krušić, Melina
Filipović, Jovanka M.
Article (Published version)
Metadata
Show full item record
Abstract
Chitosan is a natural polycationic polymer that possesses useful properties such as bioactivity, biocompatibility, non-toxicity and non-antigenicity. On the other hand, its mechanical properties are not good for some biomedical application. They may be improved by preparing semi-interpenetrating polymer networks (semi-IPNs), when the hydrogel network is prepared in the presence of a previously made polymer such as poly(ethylene glycol). This paper deals with synthesis and characterization of the semi-interpenetrating polymer networks of chitosan and poly(ethylene glycol) with different Ch/PEG ratio and crosslinking degree. The degree of deacetylation of chitosan was determined by potentiometric titration, titration and elemental analysis. The semi-IPNs were characterized by swelling kinetics, mechanical properties and thermal analysis. It was found that PEG content and crosslinking agent concentration significantly influence the swelling behaviour of semi-IPNs. Water uptake was higher ...for lower crosslinking agent concentrations and PEG contents, up to PEG/Ch = 0,75. Better mechanical strength of semi-IPNs was obtained for higher PEG content and crosslinking agent concentration. SEM analysis confirmed the porous structure of semi-IPNs. Increasing the degree of crosslinking and PEG content up to PEG/Ch = 0,75, the pore size decreased. Based on the pore size, the investigated semi-IPNs can be regarded as macroporous. Thermogravimetric analysis showed that thermal stability of the semi-IPNs depends on the degree of crosslinking, as well as on the PEG content.

Tema ovog rada je sinteza i karakterizacija semi-interpenetrirajućih polimernih mreža (semi-IPM) hitozana (Ch) i poli(etilen glikola) (PEG) sa različitim odnosom PEG/Ch i stepenom umreženja. Ispitana je kinetika bubrenja u rastvoru pH 2,2, mehanička svojstva, termička stabilnost i morfologija sintetisanih semi-IPM. Utvrđeno je da stepen umreženja i sadržaj PEG u semi-IPM utiču na bubrenje i termičku stabilnost semi- IPM. Dodatak PEG-a poboljšava mehanička svojstva za sve ispitane odnose PEG/Ch, pri čemu se stepen bubrenja semi-IPM nije mnogo promenio. Na taj način su dobijeni hidrogelovi koji dovoljno bubre i istovremeno imaju dobra mehanička svojstva, što ih čini pogodnim za primenu u medicini i farmaciji. SEM analiza je pokazala da sintetisane semi-IPM imaju poroznu strukturu. Na osnovu veličine pora, izračunate primenom teorije ravnotežnog bubrenja, ispitivane semi-IPM se mogu klasifikovati kao makroporozne.
Keywords:
hydrogel / chitosan / poly(ethylene glycol) / thermogravimetric analysis / mechanical analysis / SEM / hidrogel / hitozan / poli(etilen glikol) / termogravimetrijska analiza / mehanička analiza / SEM
Source:
Hemijska industrija, 2008, 62, 6, 345-351
Publisher:
  • Association of Chemical Engineers of Serbia
Funding / projects:
  • Sinteza i karakterizacija polimera i polimernih (nano)kompozita definisane molekulske i nadmolekulske strukture (RS-142023)

DOI: 10.2298/HEMIND0806345M

ISSN: 0367-598X

WoS: 000263752700004

Scopus: 2-s2.0-77952947499
[ Google Scholar ]
1
1
URI
http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1338
Collections
  • Radovi istraživača / Researchers’ publications (TMF)
Institution/Community
Tehnološko-metalurški fakultet
TY  - JOUR
AU  - Milosavljević, Nedeljko
AU  - Kalagasidis Krušić, Melina
AU  - Filipović, Jovanka M.
PY  - 2008
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1338
AB  - Chitosan is a natural polycationic polymer that possesses useful properties such as bioactivity, biocompatibility, non-toxicity and non-antigenicity. On the other hand, its mechanical properties are not good for some biomedical application. They may be improved by preparing semi-interpenetrating polymer networks (semi-IPNs), when the hydrogel network is prepared in the presence of a previously made polymer such as poly(ethylene glycol). This paper deals with synthesis and characterization of the semi-interpenetrating polymer networks of chitosan and poly(ethylene glycol) with different Ch/PEG ratio and crosslinking degree. The degree of deacetylation of chitosan was determined by potentiometric titration, titration and elemental analysis. The semi-IPNs were characterized by swelling kinetics, mechanical properties and thermal analysis. It was found that PEG content and crosslinking agent concentration significantly influence the swelling behaviour of semi-IPNs. Water uptake was higher for lower crosslinking agent concentrations and PEG contents, up to PEG/Ch = 0,75. Better mechanical strength of semi-IPNs was obtained for higher PEG content and crosslinking agent concentration. SEM analysis confirmed the porous structure of semi-IPNs. Increasing the degree of crosslinking and PEG content up to PEG/Ch = 0,75, the pore size decreased. Based on the pore size, the investigated semi-IPNs can be regarded as macroporous. Thermogravimetric analysis showed that thermal stability of the semi-IPNs depends on the degree of crosslinking, as well as on the PEG content.
AB  - Tema ovog rada je sinteza i karakterizacija semi-interpenetrirajućih polimernih mreža (semi-IPM) hitozana (Ch) i poli(etilen glikola) (PEG) sa različitim odnosom PEG/Ch i stepenom umreženja. Ispitana je kinetika bubrenja u rastvoru pH 2,2, mehanička svojstva, termička stabilnost i morfologija sintetisanih semi-IPM. Utvrđeno je da stepen umreženja i sadržaj PEG u semi-IPM utiču na bubrenje i termičku stabilnost semi- IPM. Dodatak PEG-a poboljšava mehanička svojstva za sve ispitane odnose PEG/Ch, pri čemu se stepen bubrenja semi-IPM nije mnogo promenio. Na taj način su dobijeni hidrogelovi koji dovoljno bubre i istovremeno imaju dobra mehanička svojstva, što ih čini pogodnim za primenu u medicini i farmaciji. SEM analiza je pokazala da sintetisane semi-IPM imaju poroznu strukturu. Na osnovu veličine pora, izračunate primenom teorije ravnotežnog bubrenja, ispitivane semi-IPM se mogu klasifikovati kao makroporozne.
PB  - Association of Chemical Engineers of Serbia
T2  - Hemijska industrija
T1  - Semi-interpenetrating polymer networks of chitosan and poly(ethylene glycol)
T1  - Semi-interpenetrirajuće mreže hitozana i poli(etilen glikola)
EP  - 351
IS  - 6
SP  - 345
VL  - 62
DO  - 10.2298/HEMIND0806345M
ER  - 
@article{
author = "Milosavljević, Nedeljko and Kalagasidis Krušić, Melina and Filipović, Jovanka M.",
year = "2008",
abstract = "Chitosan is a natural polycationic polymer that possesses useful properties such as bioactivity, biocompatibility, non-toxicity and non-antigenicity. On the other hand, its mechanical properties are not good for some biomedical application. They may be improved by preparing semi-interpenetrating polymer networks (semi-IPNs), when the hydrogel network is prepared in the presence of a previously made polymer such as poly(ethylene glycol). This paper deals with synthesis and characterization of the semi-interpenetrating polymer networks of chitosan and poly(ethylene glycol) with different Ch/PEG ratio and crosslinking degree. The degree of deacetylation of chitosan was determined by potentiometric titration, titration and elemental analysis. The semi-IPNs were characterized by swelling kinetics, mechanical properties and thermal analysis. It was found that PEG content and crosslinking agent concentration significantly influence the swelling behaviour of semi-IPNs. Water uptake was higher for lower crosslinking agent concentrations and PEG contents, up to PEG/Ch = 0,75. Better mechanical strength of semi-IPNs was obtained for higher PEG content and crosslinking agent concentration. SEM analysis confirmed the porous structure of semi-IPNs. Increasing the degree of crosslinking and PEG content up to PEG/Ch = 0,75, the pore size decreased. Based on the pore size, the investigated semi-IPNs can be regarded as macroporous. Thermogravimetric analysis showed that thermal stability of the semi-IPNs depends on the degree of crosslinking, as well as on the PEG content., Tema ovog rada je sinteza i karakterizacija semi-interpenetrirajućih polimernih mreža (semi-IPM) hitozana (Ch) i poli(etilen glikola) (PEG) sa različitim odnosom PEG/Ch i stepenom umreženja. Ispitana je kinetika bubrenja u rastvoru pH 2,2, mehanička svojstva, termička stabilnost i morfologija sintetisanih semi-IPM. Utvrđeno je da stepen umreženja i sadržaj PEG u semi-IPM utiču na bubrenje i termičku stabilnost semi- IPM. Dodatak PEG-a poboljšava mehanička svojstva za sve ispitane odnose PEG/Ch, pri čemu se stepen bubrenja semi-IPM nije mnogo promenio. Na taj način su dobijeni hidrogelovi koji dovoljno bubre i istovremeno imaju dobra mehanička svojstva, što ih čini pogodnim za primenu u medicini i farmaciji. SEM analiza je pokazala da sintetisane semi-IPM imaju poroznu strukturu. Na osnovu veličine pora, izračunate primenom teorije ravnotežnog bubrenja, ispitivane semi-IPM se mogu klasifikovati kao makroporozne.",
publisher = "Association of Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "Semi-interpenetrating polymer networks of chitosan and poly(ethylene glycol), Semi-interpenetrirajuće mreže hitozana i poli(etilen glikola)",
pages = "351-345",
number = "6",
volume = "62",
doi = "10.2298/HEMIND0806345M"
}
Milosavljević, N., Kalagasidis Krušić, M.,& Filipović, J. M.. (2008). Semi-interpenetrating polymer networks of chitosan and poly(ethylene glycol). in Hemijska industrija
Association of Chemical Engineers of Serbia., 62(6), 345-351.
https://doi.org/10.2298/HEMIND0806345M
Milosavljević N, Kalagasidis Krušić M, Filipović JM. Semi-interpenetrating polymer networks of chitosan and poly(ethylene glycol). in Hemijska industrija. 2008;62(6):345-351.
doi:10.2298/HEMIND0806345M .
Milosavljević, Nedeljko, Kalagasidis Krušić, Melina, Filipović, Jovanka M., "Semi-interpenetrating polymer networks of chitosan and poly(ethylene glycol)" in Hemijska industrija, 62, no. 6 (2008):345-351,
https://doi.org/10.2298/HEMIND0806345M . .

DSpace software copyright © 2002-2015  DuraSpace
About TechnoRep | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceInstitutions/communitiesAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About TechnoRep | Send Feedback

OpenAIRERCUB