Semi-interpenetrating polymer networks of chitosan and poly(ethylene glycol)
Semi-interpenetrirajuće mreže hitozana i poli(etilen glikola)
Article (Published version)
Metadata
Show full item recordAbstract
Chitosan is a natural polycationic polymer that possesses useful properties such as bioactivity, biocompatibility, non-toxicity and non-antigenicity. On the other hand, its mechanical properties are not good for some biomedical application. They may be improved by preparing semi-interpenetrating polymer networks (semi-IPNs), when the hydrogel network is prepared in the presence of a previously made polymer such as poly(ethylene glycol). This paper deals with synthesis and characterization of the semi-interpenetrating polymer networks of chitosan and poly(ethylene glycol) with different Ch/PEG ratio and crosslinking degree. The degree of deacetylation of chitosan was determined by potentiometric titration, titration and elemental analysis. The semi-IPNs were characterized by swelling kinetics, mechanical properties and thermal analysis. It was found that PEG content and crosslinking agent concentration significantly influence the swelling behaviour of semi-IPNs. Water uptake was higher ...for lower crosslinking agent concentrations and PEG contents, up to PEG/Ch = 0,75. Better mechanical strength of semi-IPNs was obtained for higher PEG content and crosslinking agent concentration. SEM analysis confirmed the porous structure of semi-IPNs. Increasing the degree of crosslinking and PEG content up to PEG/Ch = 0,75, the pore size decreased. Based on the pore size, the investigated semi-IPNs can be regarded as macroporous. Thermogravimetric analysis showed that thermal stability of the semi-IPNs depends on the degree of crosslinking, as well as on the PEG content.
Tema ovog rada je sinteza i karakterizacija semi-interpenetrirajućih polimernih mreža (semi-IPM) hitozana (Ch) i poli(etilen glikola) (PEG) sa različitim odnosom PEG/Ch i stepenom umreženja. Ispitana je kinetika bubrenja u rastvoru pH 2,2, mehanička svojstva, termička stabilnost i morfologija sintetisanih semi-IPM. Utvrđeno je da stepen umreženja i sadržaj PEG u semi-IPM utiču na bubrenje i termičku stabilnost semi- IPM. Dodatak PEG-a poboljšava mehanička svojstva za sve ispitane odnose PEG/Ch, pri čemu se stepen bubrenja semi-IPM nije mnogo promenio. Na taj način su dobijeni hidrogelovi koji dovoljno bubre i istovremeno imaju dobra mehanička svojstva, što ih čini pogodnim za primenu u medicini i farmaciji. SEM analiza je pokazala da sintetisane semi-IPM imaju poroznu strukturu. Na osnovu veličine pora, izračunate primenom teorije ravnotežnog bubrenja, ispitivane semi-IPM se mogu klasifikovati kao makroporozne.
Keywords:
hydrogel / chitosan / poly(ethylene glycol) / thermogravimetric analysis / mechanical analysis / SEM / hidrogel / hitozan / poli(etilen glikol) / termogravimetrijska analiza / mehanička analiza / SEMSource:
Hemijska industrija, 2008, 62, 6, 345-351Publisher:
- Association of Chemical Engineers of Serbia
Funding / projects:
- Sinteza i karakterizacija polimera i polimernih (nano)kompozita definisane molekulske i nadmolekulske strukture (RS-MESTD-MPN2006-2010-142023)
DOI: 10.2298/HEMIND0806345M
ISSN: 0367-598X
WoS: 000263752700004
Scopus: 2-s2.0-77952947499
Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Milosavljević, Nedeljko AU - Kalagasidis Krušić, Melina AU - Filipović, Jovanka M. PY - 2008 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1338 AB - Chitosan is a natural polycationic polymer that possesses useful properties such as bioactivity, biocompatibility, non-toxicity and non-antigenicity. On the other hand, its mechanical properties are not good for some biomedical application. They may be improved by preparing semi-interpenetrating polymer networks (semi-IPNs), when the hydrogel network is prepared in the presence of a previously made polymer such as poly(ethylene glycol). This paper deals with synthesis and characterization of the semi-interpenetrating polymer networks of chitosan and poly(ethylene glycol) with different Ch/PEG ratio and crosslinking degree. The degree of deacetylation of chitosan was determined by potentiometric titration, titration and elemental analysis. The semi-IPNs were characterized by swelling kinetics, mechanical properties and thermal analysis. It was found that PEG content and crosslinking agent concentration significantly influence the swelling behaviour of semi-IPNs. Water uptake was higher for lower crosslinking agent concentrations and PEG contents, up to PEG/Ch = 0,75. Better mechanical strength of semi-IPNs was obtained for higher PEG content and crosslinking agent concentration. SEM analysis confirmed the porous structure of semi-IPNs. Increasing the degree of crosslinking and PEG content up to PEG/Ch = 0,75, the pore size decreased. Based on the pore size, the investigated semi-IPNs can be regarded as macroporous. Thermogravimetric analysis showed that thermal stability of the semi-IPNs depends on the degree of crosslinking, as well as on the PEG content. AB - Tema ovog rada je sinteza i karakterizacija semi-interpenetrirajućih polimernih mreža (semi-IPM) hitozana (Ch) i poli(etilen glikola) (PEG) sa različitim odnosom PEG/Ch i stepenom umreženja. Ispitana je kinetika bubrenja u rastvoru pH 2,2, mehanička svojstva, termička stabilnost i morfologija sintetisanih semi-IPM. Utvrđeno je da stepen umreženja i sadržaj PEG u semi-IPM utiču na bubrenje i termičku stabilnost semi- IPM. Dodatak PEG-a poboljšava mehanička svojstva za sve ispitane odnose PEG/Ch, pri čemu se stepen bubrenja semi-IPM nije mnogo promenio. Na taj način su dobijeni hidrogelovi koji dovoljno bubre i istovremeno imaju dobra mehanička svojstva, što ih čini pogodnim za primenu u medicini i farmaciji. SEM analiza je pokazala da sintetisane semi-IPM imaju poroznu strukturu. Na osnovu veličine pora, izračunate primenom teorije ravnotežnog bubrenja, ispitivane semi-IPM se mogu klasifikovati kao makroporozne. PB - Association of Chemical Engineers of Serbia T2 - Hemijska industrija T1 - Semi-interpenetrating polymer networks of chitosan and poly(ethylene glycol) T1 - Semi-interpenetrirajuće mreže hitozana i poli(etilen glikola) EP - 351 IS - 6 SP - 345 VL - 62 DO - 10.2298/HEMIND0806345M ER -
@article{ author = "Milosavljević, Nedeljko and Kalagasidis Krušić, Melina and Filipović, Jovanka M.", year = "2008", abstract = "Chitosan is a natural polycationic polymer that possesses useful properties such as bioactivity, biocompatibility, non-toxicity and non-antigenicity. On the other hand, its mechanical properties are not good for some biomedical application. They may be improved by preparing semi-interpenetrating polymer networks (semi-IPNs), when the hydrogel network is prepared in the presence of a previously made polymer such as poly(ethylene glycol). This paper deals with synthesis and characterization of the semi-interpenetrating polymer networks of chitosan and poly(ethylene glycol) with different Ch/PEG ratio and crosslinking degree. The degree of deacetylation of chitosan was determined by potentiometric titration, titration and elemental analysis. The semi-IPNs were characterized by swelling kinetics, mechanical properties and thermal analysis. It was found that PEG content and crosslinking agent concentration significantly influence the swelling behaviour of semi-IPNs. Water uptake was higher for lower crosslinking agent concentrations and PEG contents, up to PEG/Ch = 0,75. Better mechanical strength of semi-IPNs was obtained for higher PEG content and crosslinking agent concentration. SEM analysis confirmed the porous structure of semi-IPNs. Increasing the degree of crosslinking and PEG content up to PEG/Ch = 0,75, the pore size decreased. Based on the pore size, the investigated semi-IPNs can be regarded as macroporous. Thermogravimetric analysis showed that thermal stability of the semi-IPNs depends on the degree of crosslinking, as well as on the PEG content., Tema ovog rada je sinteza i karakterizacija semi-interpenetrirajućih polimernih mreža (semi-IPM) hitozana (Ch) i poli(etilen glikola) (PEG) sa različitim odnosom PEG/Ch i stepenom umreženja. Ispitana je kinetika bubrenja u rastvoru pH 2,2, mehanička svojstva, termička stabilnost i morfologija sintetisanih semi-IPM. Utvrđeno je da stepen umreženja i sadržaj PEG u semi-IPM utiču na bubrenje i termičku stabilnost semi- IPM. Dodatak PEG-a poboljšava mehanička svojstva za sve ispitane odnose PEG/Ch, pri čemu se stepen bubrenja semi-IPM nije mnogo promenio. Na taj način su dobijeni hidrogelovi koji dovoljno bubre i istovremeno imaju dobra mehanička svojstva, što ih čini pogodnim za primenu u medicini i farmaciji. SEM analiza je pokazala da sintetisane semi-IPM imaju poroznu strukturu. Na osnovu veličine pora, izračunate primenom teorije ravnotežnog bubrenja, ispitivane semi-IPM se mogu klasifikovati kao makroporozne.", publisher = "Association of Chemical Engineers of Serbia", journal = "Hemijska industrija", title = "Semi-interpenetrating polymer networks of chitosan and poly(ethylene glycol), Semi-interpenetrirajuće mreže hitozana i poli(etilen glikola)", pages = "351-345", number = "6", volume = "62", doi = "10.2298/HEMIND0806345M" }
Milosavljević, N., Kalagasidis Krušić, M.,& Filipović, J. M.. (2008). Semi-interpenetrating polymer networks of chitosan and poly(ethylene glycol). in Hemijska industrija Association of Chemical Engineers of Serbia., 62(6), 345-351. https://doi.org/10.2298/HEMIND0806345M
Milosavljević N, Kalagasidis Krušić M, Filipović JM. Semi-interpenetrating polymer networks of chitosan and poly(ethylene glycol). in Hemijska industrija. 2008;62(6):345-351. doi:10.2298/HEMIND0806345M .
Milosavljević, Nedeljko, Kalagasidis Krušić, Melina, Filipović, Jovanka M., "Semi-interpenetrating polymer networks of chitosan and poly(ethylene glycol)" in Hemijska industrija, 62, no. 6 (2008):345-351, https://doi.org/10.2298/HEMIND0806345M . .