Приказ основних података о документу
Semi-interpenetrating polymer networks of chitosan and poly(ethylene glycol)
Semi-interpenetrirajuće mreže hitozana i poli(etilen glikola)
dc.creator | Milosavljević, Nedeljko | |
dc.creator | Kalagasidis Krušić, Melina | |
dc.creator | Filipović, Jovanka M. | |
dc.date.accessioned | 2021-03-10T10:59:22Z | |
dc.date.available | 2021-03-10T10:59:22Z | |
dc.date.issued | 2008 | |
dc.identifier.issn | 0367-598X | |
dc.identifier.uri | http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1338 | |
dc.description.abstract | Chitosan is a natural polycationic polymer that possesses useful properties such as bioactivity, biocompatibility, non-toxicity and non-antigenicity. On the other hand, its mechanical properties are not good for some biomedical application. They may be improved by preparing semi-interpenetrating polymer networks (semi-IPNs), when the hydrogel network is prepared in the presence of a previously made polymer such as poly(ethylene glycol). This paper deals with synthesis and characterization of the semi-interpenetrating polymer networks of chitosan and poly(ethylene glycol) with different Ch/PEG ratio and crosslinking degree. The degree of deacetylation of chitosan was determined by potentiometric titration, titration and elemental analysis. The semi-IPNs were characterized by swelling kinetics, mechanical properties and thermal analysis. It was found that PEG content and crosslinking agent concentration significantly influence the swelling behaviour of semi-IPNs. Water uptake was higher for lower crosslinking agent concentrations and PEG contents, up to PEG/Ch = 0,75. Better mechanical strength of semi-IPNs was obtained for higher PEG content and crosslinking agent concentration. SEM analysis confirmed the porous structure of semi-IPNs. Increasing the degree of crosslinking and PEG content up to PEG/Ch = 0,75, the pore size decreased. Based on the pore size, the investigated semi-IPNs can be regarded as macroporous. Thermogravimetric analysis showed that thermal stability of the semi-IPNs depends on the degree of crosslinking, as well as on the PEG content. | en |
dc.description.abstract | Tema ovog rada je sinteza i karakterizacija semi-interpenetrirajućih polimernih mreža (semi-IPM) hitozana (Ch) i poli(etilen glikola) (PEG) sa različitim odnosom PEG/Ch i stepenom umreženja. Ispitana je kinetika bubrenja u rastvoru pH 2,2, mehanička svojstva, termička stabilnost i morfologija sintetisanih semi-IPM. Utvrđeno je da stepen umreženja i sadržaj PEG u semi-IPM utiču na bubrenje i termičku stabilnost semi- IPM. Dodatak PEG-a poboljšava mehanička svojstva za sve ispitane odnose PEG/Ch, pri čemu se stepen bubrenja semi-IPM nije mnogo promenio. Na taj način su dobijeni hidrogelovi koji dovoljno bubre i istovremeno imaju dobra mehanička svojstva, što ih čini pogodnim za primenu u medicini i farmaciji. SEM analiza je pokazala da sintetisane semi-IPM imaju poroznu strukturu. Na osnovu veličine pora, izračunate primenom teorije ravnotežnog bubrenja, ispitivane semi-IPM se mogu klasifikovati kao makroporozne. | sr |
dc.publisher | Association of Chemical Engineers of Serbia | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142023/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Hemijska industrija | |
dc.subject | hydrogel | en |
dc.subject | chitosan | en |
dc.subject | poly(ethylene glycol) | en |
dc.subject | thermogravimetric analysis | en |
dc.subject | mechanical analysis | en |
dc.subject | SEM | en |
dc.subject | hidrogel | sr |
dc.subject | hitozan | sr |
dc.subject | poli(etilen glikol) | sr |
dc.subject | termogravimetrijska analiza | sr |
dc.subject | mehanička analiza | sr |
dc.subject | SEM | sr |
dc.title | Semi-interpenetrating polymer networks of chitosan and poly(ethylene glycol) | en |
dc.title | Semi-interpenetrirajuće mreže hitozana i poli(etilen glikola) | sr |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dc.citation.epage | 351 | |
dc.citation.issue | 6 | |
dc.citation.other | 62(6): 345-351 | |
dc.citation.spage | 345 | |
dc.citation.volume | 62 | |
dc.identifier.doi | 10.2298/HEMIND0806345M | |
dc.identifier.fulltext | http://TechnoRep.tmf.bg.ac.rs/bitstream/id/8596/0367-598X0806345M.pdf | |
dc.identifier.scopus | 2-s2.0-77952947499 | |
dc.identifier.wos | 000263752700004 | |
dc.type.version | publishedVersion |