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Semi-interpenetrirajuće mreže hitozana i poli(etilen glikola)

dc.creatorMilosavljević, Nedeljko
dc.creatorKalagasidis Krušić, Melina
dc.creatorFilipović, Jovanka M.
dc.date.accessioned2021-03-10T10:59:22Z
dc.date.available2021-03-10T10:59:22Z
dc.date.issued2008
dc.identifier.issn0367-598X
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/1338
dc.description.abstractChitosan is a natural polycationic polymer that possesses useful properties such as bioactivity, biocompatibility, non-toxicity and non-antigenicity. On the other hand, its mechanical properties are not good for some biomedical application. They may be improved by preparing semi-interpenetrating polymer networks (semi-IPNs), when the hydrogel network is prepared in the presence of a previously made polymer such as poly(ethylene glycol). This paper deals with synthesis and characterization of the semi-interpenetrating polymer networks of chitosan and poly(ethylene glycol) with different Ch/PEG ratio and crosslinking degree. The degree of deacetylation of chitosan was determined by potentiometric titration, titration and elemental analysis. The semi-IPNs were characterized by swelling kinetics, mechanical properties and thermal analysis. It was found that PEG content and crosslinking agent concentration significantly influence the swelling behaviour of semi-IPNs. Water uptake was higher for lower crosslinking agent concentrations and PEG contents, up to PEG/Ch = 0,75. Better mechanical strength of semi-IPNs was obtained for higher PEG content and crosslinking agent concentration. SEM analysis confirmed the porous structure of semi-IPNs. Increasing the degree of crosslinking and PEG content up to PEG/Ch = 0,75, the pore size decreased. Based on the pore size, the investigated semi-IPNs can be regarded as macroporous. Thermogravimetric analysis showed that thermal stability of the semi-IPNs depends on the degree of crosslinking, as well as on the PEG content.en
dc.description.abstractTema ovog rada je sinteza i karakterizacija semi-interpenetrirajućih polimernih mreža (semi-IPM) hitozana (Ch) i poli(etilen glikola) (PEG) sa različitim odnosom PEG/Ch i stepenom umreženja. Ispitana je kinetika bubrenja u rastvoru pH 2,2, mehanička svojstva, termička stabilnost i morfologija sintetisanih semi-IPM. Utvrđeno je da stepen umreženja i sadržaj PEG u semi-IPM utiču na bubrenje i termičku stabilnost semi- IPM. Dodatak PEG-a poboljšava mehanička svojstva za sve ispitane odnose PEG/Ch, pri čemu se stepen bubrenja semi-IPM nije mnogo promenio. Na taj način su dobijeni hidrogelovi koji dovoljno bubre i istovremeno imaju dobra mehanička svojstva, što ih čini pogodnim za primenu u medicini i farmaciji. SEM analiza je pokazala da sintetisane semi-IPM imaju poroznu strukturu. Na osnovu veličine pora, izračunate primenom teorije ravnotežnog bubrenja, ispitivane semi-IPM se mogu klasifikovati kao makroporozne.sr
dc.publisherAssociation of Chemical Engineers of Serbia
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142023/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceHemijska industrija
dc.subjecthydrogelen
dc.subjectchitosanen
dc.subjectpoly(ethylene glycol)en
dc.subjectthermogravimetric analysisen
dc.subjectmechanical analysisen
dc.subjectSEMen
dc.subjecthidrogelsr
dc.subjecthitozansr
dc.subjectpoli(etilen glikol)sr
dc.subjecttermogravimetrijska analizasr
dc.subjectmehanička analizasr
dc.subjectSEMsr
dc.titleSemi-interpenetrating polymer networks of chitosan and poly(ethylene glycol)en
dc.titleSemi-interpenetrirajuće mreže hitozana i poli(etilen glikola)sr
dc.typearticle
dc.rights.licenseBY-NC-ND
dc.citation.epage351
dc.citation.issue6
dc.citation.other62(6): 345-351
dc.citation.spage345
dc.citation.volume62
dc.identifier.doi10.2298/HEMIND0806345M
dc.identifier.fulltexthttp://TechnoRep.tmf.bg.ac.rs/bitstream/id/8596/0367-598X0806345M.pdf
dc.identifier.scopus2-s2.0-77952947499
dc.identifier.wos000263752700004
dc.type.versionpublishedVersion


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