Extraction of hyperforin and adhyperforin from St. John's Wort (Hypericum perforatum L.) by supercritical carbon dioxide
Само за регистроване кориснике
2008
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
St. John's Wort (Hypericum perforatum L.) was extracted with supercritical carbon dioxide (SC CO2) under 10, 15 and 20 MPa and at 313 and 323 K. The influence Of SC CO2 density (400-800 kg/m(3)) was examined with respect to extraction yield as well as to hyperforin and adhyperforin content, which was determined using a highly selective LC/MS/MS analytical method. A high concentration (up to 526 mg/g total extract) of two phloroglucinol derivatives was determined in this study showing that the absolute extracted amount of hyperforin and adhyperforin (mg per I g of dry plant) is almost constant not depending on total yield of extract, i.e. on density Of SC CO2. Determination of the rate of hyperforin and adhyperforin extraction at 313 K and 10 MPa showed that the maximal rates correspond to consumption of 7-8.5 9 Of CO2 per I g of dry St. John's Wort. Investigation of ultrasonic extraction of St. John's Wort followed after pre-treatment of plant material (323 K; 10 MPa; 2 h; without CO2 ...flow) indicated that obtained extract contains a higher amount (mg/g plant material) of two most important pharmacological active compounds of St. John's Wort, hyperforin and hypericin, than the extract obtained by ultrasonic extraction only.
Кључне речи:
Hypericum perforatum L. / St. John's Wort / supercritical fluid extraction / hyperforin / adhyperforinИзвор:
Journal of Supercritical Fluids, 2008, 45, 3, 332-337Издавач:
- Elsevier, Amsterdam
DOI: 10.1016/j.supflu.2008.01.003
ISSN: 0896-8446
WoS: 000256855100009
Scopus: 2-s2.0-44149120959
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Glišić, Sandra AU - Šmelcerović, Andrija AU - Zuehlke, Sebastian AU - Spiteller, Michael AU - Skala, Dejan PY - 2008 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1345 AB - St. John's Wort (Hypericum perforatum L.) was extracted with supercritical carbon dioxide (SC CO2) under 10, 15 and 20 MPa and at 313 and 323 K. The influence Of SC CO2 density (400-800 kg/m(3)) was examined with respect to extraction yield as well as to hyperforin and adhyperforin content, which was determined using a highly selective LC/MS/MS analytical method. A high concentration (up to 526 mg/g total extract) of two phloroglucinol derivatives was determined in this study showing that the absolute extracted amount of hyperforin and adhyperforin (mg per I g of dry plant) is almost constant not depending on total yield of extract, i.e. on density Of SC CO2. Determination of the rate of hyperforin and adhyperforin extraction at 313 K and 10 MPa showed that the maximal rates correspond to consumption of 7-8.5 9 Of CO2 per I g of dry St. John's Wort. Investigation of ultrasonic extraction of St. John's Wort followed after pre-treatment of plant material (323 K; 10 MPa; 2 h; without CO2 flow) indicated that obtained extract contains a higher amount (mg/g plant material) of two most important pharmacological active compounds of St. John's Wort, hyperforin and hypericin, than the extract obtained by ultrasonic extraction only. PB - Elsevier, Amsterdam T2 - Journal of Supercritical Fluids T1 - Extraction of hyperforin and adhyperforin from St. John's Wort (Hypericum perforatum L.) by supercritical carbon dioxide EP - 337 IS - 3 SP - 332 VL - 45 DO - 10.1016/j.supflu.2008.01.003 ER -
@article{ author = "Glišić, Sandra and Šmelcerović, Andrija and Zuehlke, Sebastian and Spiteller, Michael and Skala, Dejan", year = "2008", abstract = "St. John's Wort (Hypericum perforatum L.) was extracted with supercritical carbon dioxide (SC CO2) under 10, 15 and 20 MPa and at 313 and 323 K. The influence Of SC CO2 density (400-800 kg/m(3)) was examined with respect to extraction yield as well as to hyperforin and adhyperforin content, which was determined using a highly selective LC/MS/MS analytical method. A high concentration (up to 526 mg/g total extract) of two phloroglucinol derivatives was determined in this study showing that the absolute extracted amount of hyperforin and adhyperforin (mg per I g of dry plant) is almost constant not depending on total yield of extract, i.e. on density Of SC CO2. Determination of the rate of hyperforin and adhyperforin extraction at 313 K and 10 MPa showed that the maximal rates correspond to consumption of 7-8.5 9 Of CO2 per I g of dry St. John's Wort. Investigation of ultrasonic extraction of St. John's Wort followed after pre-treatment of plant material (323 K; 10 MPa; 2 h; without CO2 flow) indicated that obtained extract contains a higher amount (mg/g plant material) of two most important pharmacological active compounds of St. John's Wort, hyperforin and hypericin, than the extract obtained by ultrasonic extraction only.", publisher = "Elsevier, Amsterdam", journal = "Journal of Supercritical Fluids", title = "Extraction of hyperforin and adhyperforin from St. John's Wort (Hypericum perforatum L.) by supercritical carbon dioxide", pages = "337-332", number = "3", volume = "45", doi = "10.1016/j.supflu.2008.01.003" }
Glišić, S., Šmelcerović, A., Zuehlke, S., Spiteller, M.,& Skala, D.. (2008). Extraction of hyperforin and adhyperforin from St. John's Wort (Hypericum perforatum L.) by supercritical carbon dioxide. in Journal of Supercritical Fluids Elsevier, Amsterdam., 45(3), 332-337. https://doi.org/10.1016/j.supflu.2008.01.003
Glišić S, Šmelcerović A, Zuehlke S, Spiteller M, Skala D. Extraction of hyperforin and adhyperforin from St. John's Wort (Hypericum perforatum L.) by supercritical carbon dioxide. in Journal of Supercritical Fluids. 2008;45(3):332-337. doi:10.1016/j.supflu.2008.01.003 .
Glišić, Sandra, Šmelcerović, Andrija, Zuehlke, Sebastian, Spiteller, Michael, Skala, Dejan, "Extraction of hyperforin and adhyperforin from St. John's Wort (Hypericum perforatum L.) by supercritical carbon dioxide" in Journal of Supercritical Fluids, 45, no. 3 (2008):332-337, https://doi.org/10.1016/j.supflu.2008.01.003 . .