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Kompleksi srebra I kopolimernih hidrogelova na bazi itakonske kiseline

dc.creatorMićić, Maja M.
dc.creatorTomić, Simonida
dc.creatorFilipović, Jovanka M.
dc.creatorSuljovrujić, Edin H.
dc.description.abstractSilver(I) itaconic acid-based hydrogel complexes were synthesized and characterized in order to examine the potential use of these systems; FTIR, AFM, in vitro fluid-uptake, metal sorption and antibacterial activity assay measurements were used for the characterization. Metal (silver(I)) ion uptaken by IA-based hydrogels was determined by inductively coupled plasma mass spectrometry. The coordination sites for metal ions were identified and the stability in in vitro condition was determined. Incorporation of silver(I) ions into hydrogels and the influence of these ions on the diffusion properties of hydrogels were analyzed and discussed, too; it was found that the itaconic acid moiety in hydrogels is the determining factor which influences metal ion binding and therefore fluid uptake inside the polymeric network. Furthermore, silver(I) itaconic acid-based hydrogel showed a satisfactory antibacterial activity. The most advanced feature of these materials is that the silver ions embedded throughout the networks leaches out via controlled manner with time in aqueous media. Therefore, the ions escape from the swollen networks with time and interact with the bacteria. Because of a good dispersion of silver ions in Ag(I)-P(HEMA/2IA) hydrogel complex, we have evaluated the antibacterial activity for this sample. As expected, the number of colonies grown surrounding the Ag(I)-P(HEMA/2IA) hydrogel complex was found to be almost nil, whereas the pure P(HEMA/2IA) hydrogel did not show any effect on Escherichia coli. Therefore, we conclude that the Ag(I)-P(HEMA/IA) hydrogel complexes are excellent antibacterial materials. Due to these facts, the silver ion IA-based hydrogel complexes reported here might be used as smart materials in the range of biomedical applications, including drug-delivery devices, biosensors, wound healing dressings, tissue reconstruction and organ repair.en
dc.description.abstractSintetisani su kompleksi srebra(I) sa kopolimernim hidrogelovima 2-hidroksietil metakrilata (HEMA) i itakonske kiseline (IK) (Ag(I)-P(HEMA/IK)) u cilju ispitivanja primene ovih sistema kao biomaterijala. Uzorci su karakterisani sledećim metodama: FTIR, AFM, analiza bubrenja u in vitro uslovima, apsorpcija metala i analiza antibakterijske aktivnosti. Apsorpcija srebra(I) u hidrogelove na bazi IK je određena metodom indukovano spregnutne plazma-masene spektrometrije (ICP-MS). Analiziran je uticaj ugrađenih jona Ag na difuziona svojstva komplesiranih hidrogelova. Udeo IK u hidrogelu je preovlađujući faktor koji utiče na vezivanje Ag jona, pa otuda i na apsorpciju fluida u polimernoj mreži. Testovi antibakterijske aktivnosti su pokazali zadovoljavajuća antibakterijska svojstva biomaterijala u odnosu na soj bakterija Escherichia
dc.publisherAssociation of Chemical Engineers of Serbia
dc.sourceHemijska industrija
dc.subject2-hydroxyethyl methacrylateen
dc.subjectitaconic aciden
dc.subjectsilver(I) ionen
dc.subjectantibacterial activityen
dc.subject2-hidroksietil metakrilatsr
dc.subjectitakonska kiselinasr
dc.subjectsrebro(I) Jonsr
dc.subjectantibakterijska aktivnostsr
dc.titleSilver(I)-complexes with an itaconic acid-based hydrogelen
dc.titleKompleksi srebra I kopolimernih hidrogelova na bazi itakonske kiselinesr
dc.citation.other63(3): 137-142

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