Hydantoins: Synthesis, properties and anticonvulsant activity

Trišović, Nemanja; Ušćumlić, Gordana; Petrović, Slobodan

doi:10.2298/HEMIND0901017T

Hidantoini - dobijanje, svojstva i antikonvulzivna aktivnost

2009

0367-598X0901017T.pdf (354.8Kb)

Authors

Trišović, Nemanja

Ušćumlić, Gordana

Petrović, Slobodan

Article (Published version)

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Abstract

Hydantoin is a five-membered cyclic ureide that is present in numerous biologically active compounds including antiarrhytmics, anticonvulsants and antitumor agents. This paper describes different ways of synthesis of hydantoin-derivatives, their physical properties and reactivity. Also, the most widely used hydantoin anticonvulsants and the analysis of structureactivity relationships of anticonvulsant drugs in terms of lipophilicity and hydrogen bonding are presented here.

Hidantoin je petočlani ciklični ureid koji je sadržan u brojnim biološki aktivnim jedinjenjima kao što su antiaritmici, antikonvulzivi i antitumor agensi. U ovom radu su opisani postupci dobijanja derivata hidantoina, njihova fizička svojstva i reaktivnost. Prikazani su najčešće korišćeni antikonvulzivi iz grupe hidantoina, a razmatran je i uticaj strukture na antikovulzivnu aktivnost različitih derivata sa aspekta lipofilnosti i mogućnosti uspostavljanja vodoničnih veza.

Keywords:

hydantoin / properties / reactivity / synthesis / phenytoin / anticonvulsant activity / pharmacofor model / lipophilicity / hydrogen bonding / hidantoin / svojstva / reaktivnost / sinteza / fenitoin / anticonvulzivna aktivnost / farmakoforni model / lipofilnost / vodonične veze

Source:
Hemijska industrija, 2009, 63, 1, 17-31

Publisher:

Association of Chemical Engineers of Serbia

Funding / projects:

Proučavanje sinteze, strukture i aktivnosti organskih jedinjenja prirodnog i sintetskog porekla (RS-142063)

DOI: 10.2298/HEMIND0901017T

ISSN: 0367-598X

WoS: 000265518900003

Scopus: 2-s2.0-77952925518

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TY  - JOUR
AU  - Trišović, Nemanja
AU  - Ušćumlić, Gordana
AU  - Petrović, Slobodan
PY  - 2009
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1408
AB  - Hydantoin is a five-membered cyclic ureide that is present in numerous biologically active compounds including antiarrhytmics, anticonvulsants and antitumor agents. This paper describes different ways of synthesis of hydantoin-derivatives, their physical properties and reactivity. Also, the most widely used hydantoin anticonvulsants and the analysis of structureactivity relationships of anticonvulsant drugs in terms of lipophilicity and hydrogen bonding are presented here.
AB  - Hidantoin je petočlani ciklični ureid koji je sadržan u brojnim biološki aktivnim jedinjenjima kao što su antiaritmici, antikonvulzivi i antitumor agensi. U ovom radu su opisani postupci dobijanja derivata hidantoina, njihova fizička svojstva i reaktivnost. Prikazani su najčešće korišćeni antikonvulzivi iz grupe hidantoina, a razmatran je i uticaj strukture na antikovulzivnu aktivnost različitih derivata sa aspekta lipofilnosti i mogućnosti uspostavljanja vodoničnih veza.
PB  - Association of Chemical Engineers of Serbia
T2  - Hemijska industrija
T1  - Hydantoins: Synthesis, properties and anticonvulsant activity
T1  - Hidantoini - dobijanje, svojstva i antikonvulzivna aktivnost
EP  - 31
IS  - 1
SP  - 17
VL  - 63
DO  - 10.2298/HEMIND0901017T
ER  -

@article{
author = "Trišović, Nemanja and Ušćumlić, Gordana and Petrović, Slobodan",
year = "2009",
abstract = "Hydantoin is a five-membered cyclic ureide that is present in numerous biologically active compounds including antiarrhytmics, anticonvulsants and antitumor agents. This paper describes different ways of synthesis of hydantoin-derivatives, their physical properties and reactivity. Also, the most widely used hydantoin anticonvulsants and the analysis of structureactivity relationships of anticonvulsant drugs in terms of lipophilicity and hydrogen bonding are presented here., Hidantoin je petočlani ciklični ureid koji je sadržan u brojnim biološki aktivnim jedinjenjima kao što su antiaritmici, antikonvulzivi i antitumor agensi. U ovom radu su opisani postupci dobijanja derivata hidantoina, njihova fizička svojstva i reaktivnost. Prikazani su najčešće korišćeni antikonvulzivi iz grupe hidantoina, a razmatran je i uticaj strukture na antikovulzivnu aktivnost različitih derivata sa aspekta lipofilnosti i mogućnosti uspostavljanja vodoničnih veza.",
publisher = "Association of Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "Hydantoins: Synthesis, properties and anticonvulsant activity, Hidantoini - dobijanje, svojstva i antikonvulzivna aktivnost",
pages = "31-17",
number = "1",
volume = "63",
doi = "10.2298/HEMIND0901017T"
}

Trišović, N., Ušćumlić, G.,& Petrović, S.. (2009). Hydantoins: Synthesis, properties and anticonvulsant activity. in Hemijska industrija
Association of Chemical Engineers of Serbia., 63(1), 17-31.
https://doi.org/10.2298/HEMIND0901017T

Trišović N, Ušćumlić G, Petrović S. Hydantoins: Synthesis, properties and anticonvulsant activity. in Hemijska industrija. 2009;63(1):17-31.
doi:10.2298/HEMIND0901017T .

Trišović, Nemanja, Ušćumlić, Gordana, Petrović, Slobodan, "Hydantoins: Synthesis, properties and anticonvulsant activity" in Hemijska industrija, 63, no. 1 (2009):17-31,
https://doi.org/10.2298/HEMIND0901017T . .