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dc.creatorTomić, Simonida
dc.creatorDimitrijević, Suzana
dc.creatorMarinković, Aleksandar
dc.creatorNajman, Stevo
dc.creatorFilipović, Jovanka M.
dc.date.accessioned2021-03-10T11:07:36Z
dc.date.available2021-03-10T11:07:36Z
dc.date.issued2009
dc.identifier.issn0170-0839
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/1465
dc.description.abstractIn the present study poly(2-hydroxyethyl methacrylate-co-itaconic acid) (P(HEMA/IA)) hydrogels were synthesized by free-radical copolymerization of 2-hydroxyethyl methacrylate and itaconic acid in order to evaluate as controlled release drug delivery system. All polymerizations were performed in a mixture of water/ethanol with ethylene glycol dimethacrylate, as crosslinking agent, potassium persulfate, as initiator, and N, N, N', N'-tetramethylethylene diamine, as activator. The samples were characterized by FTIR and SEM. Swelling kinetics and antibiotic release studies were performed using gravimetry and UV spectrophotometry, respectively. The antibacterial activity studies were performed bearing in mind that infections are the most common cause of biomaterial implant failure and represent a constant menace to the application of medical implants. The hemocompatibility testing was performed as imperative for medical devices intended for direct or indirect blood exposure. In accordance with the results of antibacterial assessment on gels loaded with antibiotics and hemolytic activity testing these gels exerted good bacterial growth inhibition and favorable hemolytic activity. The release profiles of antibiotics, evaluated in vitro conditions, were correspondent for antibacterial therapeutics. Therefore, it was concluded that (P(HEMA/IA)) gels could be propound for the potential application as drug delivery systems for the controlled release of antibiotics.en
dc.publisherSpringer, New York
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145072/RS//
dc.rightsrestrictedAccess
dc.sourcePolymer Bulletin
dc.subjectHydrogelsen
dc.subject2-Hydroxyethyl methacrylateen
dc.subjectItaconic aciden
dc.subjectMorphologyen
dc.subjectHemocompatibilityen
dc.subjectControlled drug releaseen
dc.subjectAntibacterial activityen
dc.titleSynthesis and characterization of poly(2-hydroxyethyl methacrylate/itaconic acid) copolymeric hydrogelsen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage851
dc.citation.issue6
dc.citation.other63(6): 837-851
dc.citation.rankM22
dc.citation.spage837
dc.citation.volume63
dc.identifier.doi10.1007/s00289-009-0123-2
dc.identifier.rcubconv_3266
dc.identifier.scopus2-s2.0-72149124188
dc.identifier.wos000272122000006
dc.type.versionpublishedVersion


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