Semiconductor quantum dots and superparamagnetic iron oxide nanocrystals have physical properties that are well suited for biomedical imaging. Previously, we have shown that iron oxide nanocrystals embedded within the lipid core of micelles show optimized characteristics for quantitative imaging. Here, we embed quantum dots and superparamagnetic iron oxide nanocrystals in the core of lipoproteins-micelles that transport lipids and other hydrophobic substances in the blood-and show that it is possible to image and quantify the kinetics of lipoprotein metabolism in vivo using fluorescence and dynamic magnetic resonance imaging. The lipoproteins were taken up by liver cells in wild-type mice and displayed defective clearance in knock-out mice lacking a lipoprotein receptor or its ligand, indicating that the nanocrystals did not influence the specificity of the metabolic process. Using this strategy it is possible to study the clearance of lipoproteins in metabolic disorders and to improve... the contrast in clinical imaging.
Source:
Nature Nanotechnology, 2009, 4, 3, 193-201
Publisher:
Nature Publishing Group, London
Funding / projects:
Deutsche ForschungsgemeinschaftGerman Research Foundation (DFG) [HE3645/2-2, BE829/10-1, EY16/9-1]
TY - JOUR
AU - Bruns, Oliver T.
AU - Ittrich, Harald
AU - Peldschus, Kersten
AU - Kaul, Michael G.
AU - Tromsdorf, Ulrich I.
AU - Lauterwasser, Joachim
AU - Nikolić, Marija
AU - Mollwitz, Birgit
AU - Merkell, Martin
AU - Bigall, Nadja C.
AU - Sapra, Sameer
AU - Reimer, Rudolph
AU - Hohenberg, Heinz
AU - Weller, Horst
AU - Eychmueller, Alexander
AU - Adam, Gerhard
AU - Beisiegel, Ulrike
AU - Heeren, Joerg
PY - 2009
UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1479
AB - Semiconductor quantum dots and superparamagnetic iron oxide nanocrystals have physical properties that are well suited for biomedical imaging. Previously, we have shown that iron oxide nanocrystals embedded within the lipid core of micelles show optimized characteristics for quantitative imaging. Here, we embed quantum dots and superparamagnetic iron oxide nanocrystals in the core of lipoproteins-micelles that transport lipids and other hydrophobic substances in the blood-and show that it is possible to image and quantify the kinetics of lipoprotein metabolism in vivo using fluorescence and dynamic magnetic resonance imaging. The lipoproteins were taken up by liver cells in wild-type mice and displayed defective clearance in knock-out mice lacking a lipoprotein receptor or its ligand, indicating that the nanocrystals did not influence the specificity of the metabolic process. Using this strategy it is possible to study the clearance of lipoproteins in metabolic disorders and to improve the contrast in clinical imaging.
PB - Nature Publishing Group, London
T2 - Nature Nanotechnology
T1 - Real-time magnetic resonance imaging and quantification of lipoprotein metabolism in vivo using nanocrystals
EP - 201
IS - 3
SP - 193
VL - 4
DO - 10.1038/NNANO.2008.405
ER -
@article{
author = "Bruns, Oliver T. and Ittrich, Harald and Peldschus, Kersten and Kaul, Michael G. and Tromsdorf, Ulrich I. and Lauterwasser, Joachim and Nikolić, Marija and Mollwitz, Birgit and Merkell, Martin and Bigall, Nadja C. and Sapra, Sameer and Reimer, Rudolph and Hohenberg, Heinz and Weller, Horst and Eychmueller, Alexander and Adam, Gerhard and Beisiegel, Ulrike and Heeren, Joerg",
year = "2009",
abstract = "Semiconductor quantum dots and superparamagnetic iron oxide nanocrystals have physical properties that are well suited for biomedical imaging. Previously, we have shown that iron oxide nanocrystals embedded within the lipid core of micelles show optimized characteristics for quantitative imaging. Here, we embed quantum dots and superparamagnetic iron oxide nanocrystals in the core of lipoproteins-micelles that transport lipids and other hydrophobic substances in the blood-and show that it is possible to image and quantify the kinetics of lipoprotein metabolism in vivo using fluorescence and dynamic magnetic resonance imaging. The lipoproteins were taken up by liver cells in wild-type mice and displayed defective clearance in knock-out mice lacking a lipoprotein receptor or its ligand, indicating that the nanocrystals did not influence the specificity of the metabolic process. Using this strategy it is possible to study the clearance of lipoproteins in metabolic disorders and to improve the contrast in clinical imaging.",
publisher = "Nature Publishing Group, London",
journal = "Nature Nanotechnology",
title = "Real-time magnetic resonance imaging and quantification of lipoprotein metabolism in vivo using nanocrystals",
pages = "201-193",
number = "3",
volume = "4",
doi = "10.1038/NNANO.2008.405"
}
Bruns, O. T., Ittrich, H., Peldschus, K., Kaul, M. G., Tromsdorf, U. I., Lauterwasser, J., Nikolić, M., Mollwitz, B., Merkell, M., Bigall, N. C., Sapra, S., Reimer, R., Hohenberg, H., Weller, H., Eychmueller, A., Adam, G., Beisiegel, U.,& Heeren, J.. (2009). Real-time magnetic resonance imaging and quantification of lipoprotein metabolism in vivo using nanocrystals. in Nature Nanotechnology
Nature Publishing Group, London., 4(3), 193-201.
https://doi.org/10.1038/NNANO.2008.405
Bruns OT, Ittrich H, Peldschus K, Kaul MG, Tromsdorf UI, Lauterwasser J, Nikolić M, Mollwitz B, Merkell M, Bigall NC, Sapra S, Reimer R, Hohenberg H, Weller H, Eychmueller A, Adam G, Beisiegel U, Heeren J. Real-time magnetic resonance imaging and quantification of lipoprotein metabolism in vivo using nanocrystals. in Nature Nanotechnology. 2009;4(3):193-201.
doi:10.1038/NNANO.2008.405 .
Bruns, Oliver T., Ittrich, Harald, Peldschus, Kersten, Kaul, Michael G., Tromsdorf, Ulrich I., Lauterwasser, Joachim, Nikolić, Marija, Mollwitz, Birgit, Merkell, Martin, Bigall, Nadja C., Sapra, Sameer, Reimer, Rudolph, Hohenberg, Heinz, Weller, Horst, Eychmueller, Alexander, Adam, Gerhard, Beisiegel, Ulrike, Heeren, Joerg, "Real-time magnetic resonance imaging and quantification of lipoprotein metabolism in vivo using nanocrystals" in Nature Nanotechnology, 4, no. 3 (2009):193-201,
https://doi.org/10.1038/NNANO.2008.405 . .
