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dc.creatorBruns, Oliver T.
dc.creatorIttrich, Harald
dc.creatorPeldschus, Kersten
dc.creatorKaul, Michael G.
dc.creatorTromsdorf, Ulrich I.
dc.creatorLauterwasser, Joachim
dc.creatorNikolić, Marija
dc.creatorMollwitz, Birgit
dc.creatorMerkell, Martin
dc.creatorBigall, Nadja C.
dc.creatorSapra, Sameer
dc.creatorReimer, Rudolph
dc.creatorHohenberg, Heinz
dc.creatorWeller, Horst
dc.creatorEychmueller, Alexander
dc.creatorAdam, Gerhard
dc.creatorBeisiegel, Ulrike
dc.creatorHeeren, Joerg
dc.date.accessioned2021-03-10T11:08:34Z
dc.date.available2021-03-10T11:08:34Z
dc.date.issued2009
dc.identifier.issn1748-3387
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/1479
dc.description.abstractSemiconductor quantum dots and superparamagnetic iron oxide nanocrystals have physical properties that are well suited for biomedical imaging. Previously, we have shown that iron oxide nanocrystals embedded within the lipid core of micelles show optimized characteristics for quantitative imaging. Here, we embed quantum dots and superparamagnetic iron oxide nanocrystals in the core of lipoproteins-micelles that transport lipids and other hydrophobic substances in the blood-and show that it is possible to image and quantify the kinetics of lipoprotein metabolism in vivo using fluorescence and dynamic magnetic resonance imaging. The lipoproteins were taken up by liver cells in wild-type mice and displayed defective clearance in knock-out mice lacking a lipoprotein receptor or its ligand, indicating that the nanocrystals did not influence the specificity of the metabolic process. Using this strategy it is possible to study the clearance of lipoproteins in metabolic disorders and to improve the contrast in clinical imaging.en
dc.publisherNature Publishing Group, London
dc.relationDeutsche ForschungsgemeinschaftGerman Research Foundation (DFG) [HE3645/2-2, BE829/10-1, EY16/9-1]
dc.rightsrestrictedAccess
dc.sourceNature Nanotechnology
dc.titleReal-time magnetic resonance imaging and quantification of lipoprotein metabolism in vivo using nanocrystalsen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage201
dc.citation.issue3
dc.citation.other4(3): 193-201
dc.citation.rankaM21
dc.citation.spage193
dc.citation.volume4
dc.identifier.doi10.1038/NNANO.2008.405
dc.identifier.pmid19265850
dc.identifier.scopus2-s2.0-62249165791
dc.identifier.wos000264318500018
dc.type.versionpublishedVersion


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Приказ основних података о документу