TechnoRep - Faculty of Technology and Metallurgy Repository
University of Belgrade - Faculty of Technology and Metallurgy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrillic)
    • Serbian (Latin)
  • Login
View Item 
  •   TechnoRep
  • Tehnološko-metalurški fakultet
  • Radovi istraživača / Researchers’ publications (TMF)
  • View Item
  •   TechnoRep
  • Tehnološko-metalurški fakultet
  • Radovi istraživača / Researchers’ publications (TMF)
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Swelling behaviour and paracetamol release from poly(N-isopropylacrylamide-itaconic acid) hydrogels

Authorized Users Only
2009
Authors
Kalagasidis Krušić, Melina
Ilić, Marija
Filipović, Jovanka
Article (Published version)
Metadata
Show full item record
Abstract
Copolymer hydrogels of N-isopropylacrylamide and itaconic acid (IA), crosslinked with N,N'-methylenebisacrylamide, were prepared by radical copolymerization. These hydrogels were investigated with regard to their composition to find materials with satisfactory swelling and drug release properties. A paracetamol is used as a model drug to investigate drug release profile of the hydrogels. It was found that the investigated hydrogels exhibited pH- and temperature-dependent swelling behaviour with restricted swelling and lower equilibrium degree of swelling at lower pH values and temperatures above the LCST value of PNIPAM (around 34 A degrees C). The diffusion exponent for paracetamol release indicate that the mechanism of paracetamol release are governed by Fickian diffusion, while in all release media initial diffusion coefficient was lower than late time diffusion coefficient. Furthermore, the paracetamol release rate depends on the hydrogel degree of swelling and it increased in the ...first stage of diffusion process, whereas was no significant difference thereafter. The presence of the IA moieties incorporated into the network weakened the shear resistance of the hydrogels. In order to calculate the pore size the characteristic ratio for PNIPAM, C (n) = 11.7, was calculated. Based on the pore size, the investigated hydrogels can be regarded as microporous. According to the obtained results swelling behaviour, mechanical properties, drug-loading capacity and the drug release rate could be controlled by hydrogel composition and crosslinking density, which is important for application of the investigated hydrogels as drug delivery systems.

Keywords:
Swelling behaviour / Paracetamol release / Diffusion / Drug release rate
Source:
Polymer Bulletin, 2009, 63, 2, 197-211
Publisher:
  • Springer, New York
Funding / projects:
  • Sinteza i karakterizacija polimera i polimernih (nano)kompozita definisane molekulske i nadmolekulske strukture (RS-142023)

DOI: 10.1007/s00289-009-0086-3

ISSN: 0170-0839

WoS: 000267110100004

Scopus: 2-s2.0-67650438985
[ Google Scholar ]
45
34
URI
http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1506
Collections
  • Radovi istraživača / Researchers’ publications (TMF)
Institution/Community
Tehnološko-metalurški fakultet
TY  - JOUR
AU  - Kalagasidis Krušić, Melina
AU  - Ilić, Marija
AU  - Filipović, Jovanka
PY  - 2009
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1506
AB  - Copolymer hydrogels of N-isopropylacrylamide and itaconic acid (IA), crosslinked with N,N'-methylenebisacrylamide, were prepared by radical copolymerization. These hydrogels were investigated with regard to their composition to find materials with satisfactory swelling and drug release properties. A paracetamol is used as a model drug to investigate drug release profile of the hydrogels. It was found that the investigated hydrogels exhibited pH- and temperature-dependent swelling behaviour with restricted swelling and lower equilibrium degree of swelling at lower pH values and temperatures above the LCST value of PNIPAM (around 34 A degrees C). The diffusion exponent for paracetamol release indicate that the mechanism of paracetamol release are governed by Fickian diffusion, while in all release media initial diffusion coefficient was lower than late time diffusion coefficient. Furthermore, the paracetamol release rate depends on the hydrogel degree of swelling and it increased in the first stage of diffusion process, whereas was no significant difference thereafter. The presence of the IA moieties incorporated into the network weakened the shear resistance of the hydrogels. In order to calculate the pore size the characteristic ratio for PNIPAM, C (n) = 11.7, was calculated. Based on the pore size, the investigated hydrogels can be regarded as microporous. According to the obtained results swelling behaviour, mechanical properties, drug-loading capacity and the drug release rate could be controlled by hydrogel composition and crosslinking density, which is important for application of the investigated hydrogels as drug delivery systems.
PB  - Springer, New York
T2  - Polymer Bulletin
T1  - Swelling behaviour and paracetamol release from poly(N-isopropylacrylamide-itaconic acid) hydrogels
EP  - 211
IS  - 2
SP  - 197
VL  - 63
DO  - 10.1007/s00289-009-0086-3
ER  - 
@article{
author = "Kalagasidis Krušić, Melina and Ilić, Marija and Filipović, Jovanka",
year = "2009",
abstract = "Copolymer hydrogels of N-isopropylacrylamide and itaconic acid (IA), crosslinked with N,N'-methylenebisacrylamide, were prepared by radical copolymerization. These hydrogels were investigated with regard to their composition to find materials with satisfactory swelling and drug release properties. A paracetamol is used as a model drug to investigate drug release profile of the hydrogels. It was found that the investigated hydrogels exhibited pH- and temperature-dependent swelling behaviour with restricted swelling and lower equilibrium degree of swelling at lower pH values and temperatures above the LCST value of PNIPAM (around 34 A degrees C). The diffusion exponent for paracetamol release indicate that the mechanism of paracetamol release are governed by Fickian diffusion, while in all release media initial diffusion coefficient was lower than late time diffusion coefficient. Furthermore, the paracetamol release rate depends on the hydrogel degree of swelling and it increased in the first stage of diffusion process, whereas was no significant difference thereafter. The presence of the IA moieties incorporated into the network weakened the shear resistance of the hydrogels. In order to calculate the pore size the characteristic ratio for PNIPAM, C (n) = 11.7, was calculated. Based on the pore size, the investigated hydrogels can be regarded as microporous. According to the obtained results swelling behaviour, mechanical properties, drug-loading capacity and the drug release rate could be controlled by hydrogel composition and crosslinking density, which is important for application of the investigated hydrogels as drug delivery systems.",
publisher = "Springer, New York",
journal = "Polymer Bulletin",
title = "Swelling behaviour and paracetamol release from poly(N-isopropylacrylamide-itaconic acid) hydrogels",
pages = "211-197",
number = "2",
volume = "63",
doi = "10.1007/s00289-009-0086-3"
}
Kalagasidis Krušić, M., Ilić, M.,& Filipović, J.. (2009). Swelling behaviour and paracetamol release from poly(N-isopropylacrylamide-itaconic acid) hydrogels. in Polymer Bulletin
Springer, New York., 63(2), 197-211.
https://doi.org/10.1007/s00289-009-0086-3
Kalagasidis Krušić M, Ilić M, Filipović J. Swelling behaviour and paracetamol release from poly(N-isopropylacrylamide-itaconic acid) hydrogels. in Polymer Bulletin. 2009;63(2):197-211.
doi:10.1007/s00289-009-0086-3 .
Kalagasidis Krušić, Melina, Ilić, Marija, Filipović, Jovanka, "Swelling behaviour and paracetamol release from poly(N-isopropylacrylamide-itaconic acid) hydrogels" in Polymer Bulletin, 63, no. 2 (2009):197-211,
https://doi.org/10.1007/s00289-009-0086-3 . .

DSpace software copyright © 2002-2015  DuraSpace
About TechnoRep | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceInstitutions/communitiesAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About TechnoRep | Send Feedback

OpenAIRERCUB