Swelling behaviour and paracetamol release from poly(N-isopropylacrylamide-itaconic acid) hydrogels
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2009
Članak u časopisu (Objavljena verzija)

Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Copolymer hydrogels of N-isopropylacrylamide and itaconic acid (IA), crosslinked with N,N'-methylenebisacrylamide, were prepared by radical copolymerization. These hydrogels were investigated with regard to their composition to find materials with satisfactory swelling and drug release properties. A paracetamol is used as a model drug to investigate drug release profile of the hydrogels. It was found that the investigated hydrogels exhibited pH- and temperature-dependent swelling behaviour with restricted swelling and lower equilibrium degree of swelling at lower pH values and temperatures above the LCST value of PNIPAM (around 34 A degrees C). The diffusion exponent for paracetamol release indicate that the mechanism of paracetamol release are governed by Fickian diffusion, while in all release media initial diffusion coefficient was lower than late time diffusion coefficient. Furthermore, the paracetamol release rate depends on the hydrogel degree of swelling and it increased in the ...first stage of diffusion process, whereas was no significant difference thereafter. The presence of the IA moieties incorporated into the network weakened the shear resistance of the hydrogels. In order to calculate the pore size the characteristic ratio for PNIPAM, C (n) = 11.7, was calculated. Based on the pore size, the investigated hydrogels can be regarded as microporous. According to the obtained results swelling behaviour, mechanical properties, drug-loading capacity and the drug release rate could be controlled by hydrogel composition and crosslinking density, which is important for application of the investigated hydrogels as drug delivery systems.
Ključne reči:
Swelling behaviour / Paracetamol release / Diffusion / Drug release rateIzvor:
Polymer Bulletin, 2009, 63, 2, 197-211Izdavač:
- Springer, New York
Finansiranje / projekti:
DOI: 10.1007/s00289-009-0086-3
ISSN: 0170-0839
WoS: 000267110100004
Scopus: 2-s2.0-67650438985
Institucija/grupa
Tehnološko-metalurški fakultetTY - JOUR AU - Kalagasidis Krušić, Melina AU - Ilić, Marija AU - Filipović, Jovanka PY - 2009 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1506 AB - Copolymer hydrogels of N-isopropylacrylamide and itaconic acid (IA), crosslinked with N,N'-methylenebisacrylamide, were prepared by radical copolymerization. These hydrogels were investigated with regard to their composition to find materials with satisfactory swelling and drug release properties. A paracetamol is used as a model drug to investigate drug release profile of the hydrogels. It was found that the investigated hydrogels exhibited pH- and temperature-dependent swelling behaviour with restricted swelling and lower equilibrium degree of swelling at lower pH values and temperatures above the LCST value of PNIPAM (around 34 A degrees C). The diffusion exponent for paracetamol release indicate that the mechanism of paracetamol release are governed by Fickian diffusion, while in all release media initial diffusion coefficient was lower than late time diffusion coefficient. Furthermore, the paracetamol release rate depends on the hydrogel degree of swelling and it increased in the first stage of diffusion process, whereas was no significant difference thereafter. The presence of the IA moieties incorporated into the network weakened the shear resistance of the hydrogels. In order to calculate the pore size the characteristic ratio for PNIPAM, C (n) = 11.7, was calculated. Based on the pore size, the investigated hydrogels can be regarded as microporous. According to the obtained results swelling behaviour, mechanical properties, drug-loading capacity and the drug release rate could be controlled by hydrogel composition and crosslinking density, which is important for application of the investigated hydrogels as drug delivery systems. PB - Springer, New York T2 - Polymer Bulletin T1 - Swelling behaviour and paracetamol release from poly(N-isopropylacrylamide-itaconic acid) hydrogels EP - 211 IS - 2 SP - 197 VL - 63 DO - 10.1007/s00289-009-0086-3 ER -
@article{ author = "Kalagasidis Krušić, Melina and Ilić, Marija and Filipović, Jovanka", year = "2009", abstract = "Copolymer hydrogels of N-isopropylacrylamide and itaconic acid (IA), crosslinked with N,N'-methylenebisacrylamide, were prepared by radical copolymerization. These hydrogels were investigated with regard to their composition to find materials with satisfactory swelling and drug release properties. A paracetamol is used as a model drug to investigate drug release profile of the hydrogels. It was found that the investigated hydrogels exhibited pH- and temperature-dependent swelling behaviour with restricted swelling and lower equilibrium degree of swelling at lower pH values and temperatures above the LCST value of PNIPAM (around 34 A degrees C). The diffusion exponent for paracetamol release indicate that the mechanism of paracetamol release are governed by Fickian diffusion, while in all release media initial diffusion coefficient was lower than late time diffusion coefficient. Furthermore, the paracetamol release rate depends on the hydrogel degree of swelling and it increased in the first stage of diffusion process, whereas was no significant difference thereafter. The presence of the IA moieties incorporated into the network weakened the shear resistance of the hydrogels. In order to calculate the pore size the characteristic ratio for PNIPAM, C (n) = 11.7, was calculated. Based on the pore size, the investigated hydrogels can be regarded as microporous. According to the obtained results swelling behaviour, mechanical properties, drug-loading capacity and the drug release rate could be controlled by hydrogel composition and crosslinking density, which is important for application of the investigated hydrogels as drug delivery systems.", publisher = "Springer, New York", journal = "Polymer Bulletin", title = "Swelling behaviour and paracetamol release from poly(N-isopropylacrylamide-itaconic acid) hydrogels", pages = "211-197", number = "2", volume = "63", doi = "10.1007/s00289-009-0086-3" }
Kalagasidis Krušić, M., Ilić, M.,& Filipović, J.. (2009). Swelling behaviour and paracetamol release from poly(N-isopropylacrylamide-itaconic acid) hydrogels. in Polymer Bulletin Springer, New York., 63(2), 197-211. https://doi.org/10.1007/s00289-009-0086-3
Kalagasidis Krušić M, Ilić M, Filipović J. Swelling behaviour and paracetamol release from poly(N-isopropylacrylamide-itaconic acid) hydrogels. in Polymer Bulletin. 2009;63(2):197-211. doi:10.1007/s00289-009-0086-3 .
Kalagasidis Krušić, Melina, Ilić, Marija, Filipović, Jovanka, "Swelling behaviour and paracetamol release from poly(N-isopropylacrylamide-itaconic acid) hydrogels" in Polymer Bulletin, 63, no. 2 (2009):197-211, https://doi.org/10.1007/s00289-009-0086-3 . .