Synthesis of substituted 3-cyano-2-pyridones: Part III - Enzyme kinetics
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1998
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Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Lipases from Candida cylindracea and hog pancreas have been used to study the reaction kinetics of enzyme catalysed synthesis of substituted 3-cyano-2-pyridones by cyclization of 1,3-diketones with cyanoacetamide. Influence of diketone:cyanoacetamide ratio, enzyme:substrate ratio, temperature, organic media, type of enzyme and alkyl substituents on the reaction is reported. Kinetics for allosteric enzymes is indicated and apparent rate constants are calculated. However, the activation parameters obtained are more compatible with the Henry-Michaelis-Menten approach and the corresponding kinetics is also discussed.
Izvor:
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1998, 37, 10, 988-994Izdavač:
- Natl Inst Science Communication, New Delhi
Institucija/grupa
Tehnološko-metalurški fakultetTY - JOUR AU - Mijin, Dušan AU - Mišić-Vuković, Milica PY - 1998 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/161 AB - Lipases from Candida cylindracea and hog pancreas have been used to study the reaction kinetics of enzyme catalysed synthesis of substituted 3-cyano-2-pyridones by cyclization of 1,3-diketones with cyanoacetamide. Influence of diketone:cyanoacetamide ratio, enzyme:substrate ratio, temperature, organic media, type of enzyme and alkyl substituents on the reaction is reported. Kinetics for allosteric enzymes is indicated and apparent rate constants are calculated. However, the activation parameters obtained are more compatible with the Henry-Michaelis-Menten approach and the corresponding kinetics is also discussed. PB - Natl Inst Science Communication, New Delhi T2 - Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry T1 - Synthesis of substituted 3-cyano-2-pyridones: Part III - Enzyme kinetics EP - 994 IS - 10 SP - 988 VL - 37 UR - https://hdl.handle.net/21.15107/rcub_technorep_161 ER -
@article{ author = "Mijin, Dušan and Mišić-Vuković, Milica", year = "1998", abstract = "Lipases from Candida cylindracea and hog pancreas have been used to study the reaction kinetics of enzyme catalysed synthesis of substituted 3-cyano-2-pyridones by cyclization of 1,3-diketones with cyanoacetamide. Influence of diketone:cyanoacetamide ratio, enzyme:substrate ratio, temperature, organic media, type of enzyme and alkyl substituents on the reaction is reported. Kinetics for allosteric enzymes is indicated and apparent rate constants are calculated. However, the activation parameters obtained are more compatible with the Henry-Michaelis-Menten approach and the corresponding kinetics is also discussed.", publisher = "Natl Inst Science Communication, New Delhi", journal = "Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry", title = "Synthesis of substituted 3-cyano-2-pyridones: Part III - Enzyme kinetics", pages = "994-988", number = "10", volume = "37", url = "https://hdl.handle.net/21.15107/rcub_technorep_161" }
Mijin, D.,& Mišić-Vuković, M.. (1998). Synthesis of substituted 3-cyano-2-pyridones: Part III - Enzyme kinetics. in Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry Natl Inst Science Communication, New Delhi., 37(10), 988-994. https://hdl.handle.net/21.15107/rcub_technorep_161
Mijin D, Mišić-Vuković M. Synthesis of substituted 3-cyano-2-pyridones: Part III - Enzyme kinetics. in Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry. 1998;37(10):988-994. https://hdl.handle.net/21.15107/rcub_technorep_161 .
Mijin, Dušan, Mišić-Vuković, Milica, "Synthesis of substituted 3-cyano-2-pyridones: Part III - Enzyme kinetics" in Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 37, no. 10 (1998):988-994, https://hdl.handle.net/21.15107/rcub_technorep_161 .