TechnoRep - Faculty of Technology and Metallurgy Repository
University of Belgrade - Faculty of Technology and Metallurgy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrillic)
    • Serbian (Latin)
  • Login
View Item 
  •   TechnoRep
  • Tehnološko-metalurški fakultet
  • Radovi istraživača / Researchers’ publications (TMF)
  • View Item
  •   TechnoRep
  • Tehnološko-metalurški fakultet
  • Radovi istraživača / Researchers’ publications (TMF)
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Synthesis and characterization of phencyclidine and its derivatives

Sinteza i karakterizacija fenciklidina i njegovih derivata

Thumbnail
2010
0367-598X1000050I.pdf (595.9Kb)
Authors
Ilić, Nataša
Marinković, Aleksandar
Brković, Danijela V.
Petrović, Slobodan
Article (Published version)
Metadata
Show full item record
Abstract
Phencyclidine (PCP) or 1-phenyl-cyclohexylpiperidine is the best-known representative drug from the compound class of arylcyclohexylamines. On a pharmacological activities basis, it belongs to the family of drugs known as dissociative anesthetics. In recent years, great attention has been paid to the investigation of substances that have been abused, including PCP. PCP is a synthetic drug with stimulating and hallucinogenic effects (street name 'angel dust'), and it is included in the Schedule Substances List in Serbia and worldwide. In the beginning, PCP has been sold in pharmacies as a local anesthetic, but very quickly it was withdrawn from sale because of unwanted effects on consumer health causing psychoactive addiction. Taking into account that great attention is being given nowadays to substances that are subject of abuse, biological and pharmacological effects of PCP and its derivative, which depend on their structure and methods for synthesis, is described in this paper. It is... shown that PCP is antagonist of N-methyl-D-aspartate (NMDA) and that it causes antiglutamatergic hallucinations, unlike BTCP whose agonist is an NMDA receptor and is obtained by modifying the structure of PCP. This paper presents a PCP metabolism and provides an overview of the methods for their identification and quantification in biological samples. Immunological tests of PCP in biological samples can provide a quick but wrong result because of the possible interference with the other substances of abuse as opposed to instrumental methods. Based on the presented method and the results it was concluded that the method of choice for the examinations of biological samples for the presence of PCP is gas chromatography in combination with mass spectroscopy.

Fenciklidin (PCP) ili 1-fenil-cikloheksilpiperidin spada u klasu arilcikloheksilaminskih derivata i po svojoj farmakološkoj aktivnosti pripada familiji disocijativnih anestetika. PCP je sintetička droga sa stimulativnim i halucinogenim dejstvom, koja se prvobitno pojavila u apotekama kao lokalni anestetik, ali je vrlo brzo povučena iz prodaje zbog neželjenih efekata po zdravlje njenih konzumenata i postala je predmet zloupotrebe. S obzirom da se danas velika pažnja poklanja supstancama koja su predmet zloupotrebe, u ovom radu je opisano biološko i farmakološko dejstvo PCP i njegovih derivata u zavisnosti od njihove strukture, kao i metode za dobijanje istog. Pokazano je da je PCP antagonist N-metil-D-aspartat (NMDA) receptora, koji blokira aktivnost NMDA receptora te dovodi do antiglutamatergičnih halucinacija. U radu je prikazan metabolizam PCP kao i pregled metoda za njegovo dokazivanje i kvantifikaciju u biološkim uzorcima jer se nalazi na tzv. Listi supstanci pod kontrolom. Na osno...vu rezultata koja su dobijena kvalitativnim i kvantitativnim ispitivanjem PCP u biološkim uzorcima može se zaključiti da su hromatografske i spektrografske metoda najosetljivije za razdvajanje i detekciju PCP.

Keywords:
Phencyclidine / anesthetic drug / N-Methyl-D-aspartate(NMDA) receptor / schedule substances / Dissociative anesthetics / antiglutamateric hallucinations / Fenciklidin / anestetička droga / N-Metil-D-aspartat(NMDA) receptor / supstance pod kontrolom / Disocijativni anestetik / antiglutamatergične halucinacije
Source:
Hemijska industrija, 2010, 64, 5, 389-400
Publisher:
  • Association of Chemical Engineers of Serbia

DOI: 10.2298/HEMIND100523050I

ISSN: 0367-598X

WoS: 000285175800004

Scopus: 2-s2.0-78449270844
[ Google Scholar ]
URI
http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1659
Collections
  • Radovi istraživača / Researchers’ publications (TMF)
Institution/Community
Tehnološko-metalurški fakultet
TY  - JOUR
AU  - Ilić, Nataša
AU  - Marinković, Aleksandar
AU  - Brković, Danijela V.
AU  - Petrović, Slobodan
PY  - 2010
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1659
AB  - Phencyclidine (PCP) or 1-phenyl-cyclohexylpiperidine is the best-known representative drug from the compound class of arylcyclohexylamines. On a pharmacological activities basis, it belongs to the family of drugs known as dissociative anesthetics. In recent years, great attention has been paid to the investigation of substances that have been abused, including PCP. PCP is a synthetic drug with stimulating and hallucinogenic effects (street name 'angel dust'), and it is included in the Schedule Substances List in Serbia and worldwide. In the beginning, PCP has been sold in pharmacies as a local anesthetic, but very quickly it was withdrawn from sale because of unwanted effects on consumer health causing psychoactive addiction. Taking into account that great attention is being given nowadays to substances that are subject of abuse, biological and pharmacological effects of PCP and its derivative, which depend on their structure and methods for synthesis, is described in this paper. It is shown that PCP is antagonist of N-methyl-D-aspartate (NMDA) and that it causes antiglutamatergic hallucinations, unlike BTCP whose agonist is an NMDA receptor and is obtained by modifying the structure of PCP. This paper presents a PCP metabolism and provides an overview of the methods for their identification and quantification in biological samples. Immunological tests of PCP in biological samples can provide a quick but wrong result because of the possible interference with the other substances of abuse as opposed to instrumental methods. Based on the presented method and the results it was concluded that the method of choice for the examinations of biological samples for the presence of PCP is gas chromatography in combination with mass spectroscopy.
AB  - Fenciklidin (PCP) ili 1-fenil-cikloheksilpiperidin spada u klasu arilcikloheksilaminskih derivata i po svojoj farmakološkoj aktivnosti pripada familiji disocijativnih anestetika. PCP je sintetička droga sa stimulativnim i halucinogenim dejstvom, koja se prvobitno pojavila u apotekama kao lokalni anestetik, ali je vrlo brzo povučena iz prodaje zbog neželjenih efekata po zdravlje njenih konzumenata i postala je predmet zloupotrebe. S obzirom da se danas velika pažnja poklanja supstancama koja su predmet zloupotrebe, u ovom radu je opisano biološko i farmakološko dejstvo PCP i njegovih derivata u zavisnosti od njihove strukture, kao i metode za dobijanje istog. Pokazano je da je PCP antagonist N-metil-D-aspartat (NMDA) receptora, koji blokira aktivnost NMDA receptora te dovodi do antiglutamatergičnih halucinacija. U radu je prikazan metabolizam PCP kao i pregled metoda za njegovo dokazivanje i kvantifikaciju u biološkim uzorcima jer se nalazi na tzv. Listi supstanci pod kontrolom. Na osnovu rezultata koja su dobijena kvalitativnim i kvantitativnim ispitivanjem PCP u biološkim uzorcima može se zaključiti da su hromatografske i spektrografske metoda najosetljivije za razdvajanje i detekciju PCP.
PB  - Association of Chemical Engineers of Serbia
T2  - Hemijska industrija
T1  - Synthesis and characterization of phencyclidine and its derivatives
T1  - Sinteza i karakterizacija fenciklidina i njegovih derivata
EP  - 400
IS  - 5
SP  - 389
VL  - 64
DO  - 10.2298/HEMIND100523050I
ER  - 
@article{
author = "Ilić, Nataša and Marinković, Aleksandar and Brković, Danijela V. and Petrović, Slobodan",
year = "2010",
abstract = "Phencyclidine (PCP) or 1-phenyl-cyclohexylpiperidine is the best-known representative drug from the compound class of arylcyclohexylamines. On a pharmacological activities basis, it belongs to the family of drugs known as dissociative anesthetics. In recent years, great attention has been paid to the investigation of substances that have been abused, including PCP. PCP is a synthetic drug with stimulating and hallucinogenic effects (street name 'angel dust'), and it is included in the Schedule Substances List in Serbia and worldwide. In the beginning, PCP has been sold in pharmacies as a local anesthetic, but very quickly it was withdrawn from sale because of unwanted effects on consumer health causing psychoactive addiction. Taking into account that great attention is being given nowadays to substances that are subject of abuse, biological and pharmacological effects of PCP and its derivative, which depend on their structure and methods for synthesis, is described in this paper. It is shown that PCP is antagonist of N-methyl-D-aspartate (NMDA) and that it causes antiglutamatergic hallucinations, unlike BTCP whose agonist is an NMDA receptor and is obtained by modifying the structure of PCP. This paper presents a PCP metabolism and provides an overview of the methods for their identification and quantification in biological samples. Immunological tests of PCP in biological samples can provide a quick but wrong result because of the possible interference with the other substances of abuse as opposed to instrumental methods. Based on the presented method and the results it was concluded that the method of choice for the examinations of biological samples for the presence of PCP is gas chromatography in combination with mass spectroscopy., Fenciklidin (PCP) ili 1-fenil-cikloheksilpiperidin spada u klasu arilcikloheksilaminskih derivata i po svojoj farmakološkoj aktivnosti pripada familiji disocijativnih anestetika. PCP je sintetička droga sa stimulativnim i halucinogenim dejstvom, koja se prvobitno pojavila u apotekama kao lokalni anestetik, ali je vrlo brzo povučena iz prodaje zbog neželjenih efekata po zdravlje njenih konzumenata i postala je predmet zloupotrebe. S obzirom da se danas velika pažnja poklanja supstancama koja su predmet zloupotrebe, u ovom radu je opisano biološko i farmakološko dejstvo PCP i njegovih derivata u zavisnosti od njihove strukture, kao i metode za dobijanje istog. Pokazano je da je PCP antagonist N-metil-D-aspartat (NMDA) receptora, koji blokira aktivnost NMDA receptora te dovodi do antiglutamatergičnih halucinacija. U radu je prikazan metabolizam PCP kao i pregled metoda za njegovo dokazivanje i kvantifikaciju u biološkim uzorcima jer se nalazi na tzv. Listi supstanci pod kontrolom. Na osnovu rezultata koja su dobijena kvalitativnim i kvantitativnim ispitivanjem PCP u biološkim uzorcima može se zaključiti da su hromatografske i spektrografske metoda najosetljivije za razdvajanje i detekciju PCP.",
publisher = "Association of Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "Synthesis and characterization of phencyclidine and its derivatives, Sinteza i karakterizacija fenciklidina i njegovih derivata",
pages = "400-389",
number = "5",
volume = "64",
doi = "10.2298/HEMIND100523050I"
}
Ilić, N., Marinković, A., Brković, D. V.,& Petrović, S.. (2010). Synthesis and characterization of phencyclidine and its derivatives. in Hemijska industrija
Association of Chemical Engineers of Serbia., 64(5), 389-400.
https://doi.org/10.2298/HEMIND100523050I
Ilić N, Marinković A, Brković DV, Petrović S. Synthesis and characterization of phencyclidine and its derivatives. in Hemijska industrija. 2010;64(5):389-400.
doi:10.2298/HEMIND100523050I .
Ilić, Nataša, Marinković, Aleksandar, Brković, Danijela V., Petrović, Slobodan, "Synthesis and characterization of phencyclidine and its derivatives" in Hemijska industrija, 64, no. 5 (2010):389-400,
https://doi.org/10.2298/HEMIND100523050I . .

DSpace software copyright © 2002-2015  DuraSpace
About TechnoRep | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceInstitutions/communitiesAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About TechnoRep | Send Feedback

OpenAIRERCUB