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Sinteza i karakterizacija fenciklidina i njegovih derivata

dc.creatorIlić, Nataša
dc.creatorMarinković, Aleksandar
dc.creatorBrković, Danijela V.
dc.creatorPetrović, Slobodan
dc.description.abstractPhencyclidine (PCP) or 1-phenyl-cyclohexylpiperidine is the best-known representative drug from the compound class of arylcyclohexylamines. On a pharmacological activities basis, it belongs to the family of drugs known as dissociative anesthetics. In recent years, great attention has been paid to the investigation of substances that have been abused, including PCP. PCP is a synthetic drug with stimulating and hallucinogenic effects (street name 'angel dust'), and it is included in the Schedule Substances List in Serbia and worldwide. In the beginning, PCP has been sold in pharmacies as a local anesthetic, but very quickly it was withdrawn from sale because of unwanted effects on consumer health causing psychoactive addiction. Taking into account that great attention is being given nowadays to substances that are subject of abuse, biological and pharmacological effects of PCP and its derivative, which depend on their structure and methods for synthesis, is described in this paper. It is shown that PCP is antagonist of N-methyl-D-aspartate (NMDA) and that it causes antiglutamatergic hallucinations, unlike BTCP whose agonist is an NMDA receptor and is obtained by modifying the structure of PCP. This paper presents a PCP metabolism and provides an overview of the methods for their identification and quantification in biological samples. Immunological tests of PCP in biological samples can provide a quick but wrong result because of the possible interference with the other substances of abuse as opposed to instrumental methods. Based on the presented method and the results it was concluded that the method of choice for the examinations of biological samples for the presence of PCP is gas chromatography in combination with mass spectroscopy.en
dc.description.abstractFenciklidin (PCP) ili 1-fenil-cikloheksilpiperidin spada u klasu arilcikloheksilaminskih derivata i po svojoj farmakološkoj aktivnosti pripada familiji disocijativnih anestetika. PCP je sintetička droga sa stimulativnim i halucinogenim dejstvom, koja se prvobitno pojavila u apotekama kao lokalni anestetik, ali je vrlo brzo povučena iz prodaje zbog neželjenih efekata po zdravlje njenih konzumenata i postala je predmet zloupotrebe. S obzirom da se danas velika pažnja poklanja supstancama koja su predmet zloupotrebe, u ovom radu je opisano biološko i farmakološko dejstvo PCP i njegovih derivata u zavisnosti od njihove strukture, kao i metode za dobijanje istog. Pokazano je da je PCP antagonist N-metil-D-aspartat (NMDA) receptora, koji blokira aktivnost NMDA receptora te dovodi do antiglutamatergičnih halucinacija. U radu je prikazan metabolizam PCP kao i pregled metoda za njegovo dokazivanje i kvantifikaciju u biološkim uzorcima jer se nalazi na tzv. Listi supstanci pod kontrolom. Na osnovu rezultata koja su dobijena kvalitativnim i kvantitativnim ispitivanjem PCP u biološkim uzorcima može se zaključiti da su hromatografske i spektrografske metoda najosetljivije za razdvajanje i detekciju
dc.publisherAssociation of Chemical Engineers of Serbia
dc.sourceHemijska industrija
dc.subjectanesthetic drugen
dc.subjectN-Methyl-D-aspartate(NMDA) receptoren
dc.subjectschedule substancesen
dc.subjectDissociative anestheticsen
dc.subjectantiglutamateric hallucinationsen
dc.subjectanestetička drogasr
dc.subjectN-Metil-D-aspartat(NMDA) receptorsr
dc.subjectsupstance pod kontrolomsr
dc.subjectDisocijativni anestetiksr
dc.subjectantiglutamatergične halucinacijesr
dc.titleSynthesis and characterization of phencyclidine and its derivativesen
dc.titleSinteza i karakterizacija fenciklidina i njegovih derivatasr
dc.citation.other64(5): 389-400

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