CdSe/CdS nanoparticles immobilized on pNIPAm-based microspheres
Само за регистроване кориснике
2010
Аутори
Salcher, AndreaNikolić, Marija
Casado, Santiago
Velez, Marisela
Weller, Horst
Juarez, Beatriz H.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
In this work, CdSe/CdS semiconductor ligand-exchanged nanoparticles have been immobilized on poly-(N-isopropylacrylamide) (pNIPAM)-based microspheres. The size and the shrinkage capacity of the spheres can be tuned by the ratio of NIPAM/styrene (pNIPAM-PS spheres) or NIPAM/BIS (N-N'-methylene-bis-acrylamide) and MA (maleic acid) (pNIPAM-BIS-MA spheres). A ligand-exchange procedure for the transfer of initially organic compatible nanoparticles into aqueous solution using amine-modified or thiol-modified poly(ethylene oxide)s (PEOs) has been carried out prior to their immobilization. We observed that the interaction of the nanoparticles with the pNIPAM-based system depends on the nature of the ligands and the chemical composition of the microspheres. Nanoparticles capped with amine-or mercapto-poly(ethylene oxide) s ligands interact with pNIPAM-PS beads while only amine-capped ones show a clear tendency to interact with pNIPAM containing acid groups which leads to a high nanoparticle cov...erage. Dynamic light scattering measurements, atomic force microscopy and optical spectroscopy hint that nanoparticles are placed on the surface of pNIPAM-BIS-MA beads while being partially incorporated into pNIPAM-PS network. Cell culture studies demonstrate that the fluorescent composites show non-specific binding to fibroblasts. These features may be very valuable to develop materials for drug delivery and specific targeting of cells combined with the outstanding optical properties of semiconductor nanoparticles as fluorescent labelers.
Извор:
Journal of Materials Chemistry, 2010, 20, 7, 1367-1374Издавач:
- Royal Soc Chemistry, Cambridge
Финансирање / пројекти:
- European CommissionEuropean CommissionEuropean Commission Joint Research Centre
- Ministerio de Ciencia e InnovacionInstituto de Salud Carlos IIISpanish Government [CONSOLIDER-INGENIOCSD00C-07-25200]
- Comunidad Autonoma de MadridComunidad de Madrid [S-0505/MAT-0283]
DOI: 10.1039/b917022g
ISSN: 0959-9428
WoS: 000274207500018
Scopus: 2-s2.0-75749113670
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Salcher, Andrea AU - Nikolić, Marija AU - Casado, Santiago AU - Velez, Marisela AU - Weller, Horst AU - Juarez, Beatriz H. PY - 2010 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1687 AB - In this work, CdSe/CdS semiconductor ligand-exchanged nanoparticles have been immobilized on poly-(N-isopropylacrylamide) (pNIPAM)-based microspheres. The size and the shrinkage capacity of the spheres can be tuned by the ratio of NIPAM/styrene (pNIPAM-PS spheres) or NIPAM/BIS (N-N'-methylene-bis-acrylamide) and MA (maleic acid) (pNIPAM-BIS-MA spheres). A ligand-exchange procedure for the transfer of initially organic compatible nanoparticles into aqueous solution using amine-modified or thiol-modified poly(ethylene oxide)s (PEOs) has been carried out prior to their immobilization. We observed that the interaction of the nanoparticles with the pNIPAM-based system depends on the nature of the ligands and the chemical composition of the microspheres. Nanoparticles capped with amine-or mercapto-poly(ethylene oxide) s ligands interact with pNIPAM-PS beads while only amine-capped ones show a clear tendency to interact with pNIPAM containing acid groups which leads to a high nanoparticle coverage. Dynamic light scattering measurements, atomic force microscopy and optical spectroscopy hint that nanoparticles are placed on the surface of pNIPAM-BIS-MA beads while being partially incorporated into pNIPAM-PS network. Cell culture studies demonstrate that the fluorescent composites show non-specific binding to fibroblasts. These features may be very valuable to develop materials for drug delivery and specific targeting of cells combined with the outstanding optical properties of semiconductor nanoparticles as fluorescent labelers. PB - Royal Soc Chemistry, Cambridge T2 - Journal of Materials Chemistry T1 - CdSe/CdS nanoparticles immobilized on pNIPAm-based microspheres EP - 1374 IS - 7 SP - 1367 VL - 20 DO - 10.1039/b917022g ER -
@article{ author = "Salcher, Andrea and Nikolić, Marija and Casado, Santiago and Velez, Marisela and Weller, Horst and Juarez, Beatriz H.", year = "2010", abstract = "In this work, CdSe/CdS semiconductor ligand-exchanged nanoparticles have been immobilized on poly-(N-isopropylacrylamide) (pNIPAM)-based microspheres. The size and the shrinkage capacity of the spheres can be tuned by the ratio of NIPAM/styrene (pNIPAM-PS spheres) or NIPAM/BIS (N-N'-methylene-bis-acrylamide) and MA (maleic acid) (pNIPAM-BIS-MA spheres). A ligand-exchange procedure for the transfer of initially organic compatible nanoparticles into aqueous solution using amine-modified or thiol-modified poly(ethylene oxide)s (PEOs) has been carried out prior to their immobilization. We observed that the interaction of the nanoparticles with the pNIPAM-based system depends on the nature of the ligands and the chemical composition of the microspheres. Nanoparticles capped with amine-or mercapto-poly(ethylene oxide) s ligands interact with pNIPAM-PS beads while only amine-capped ones show a clear tendency to interact with pNIPAM containing acid groups which leads to a high nanoparticle coverage. Dynamic light scattering measurements, atomic force microscopy and optical spectroscopy hint that nanoparticles are placed on the surface of pNIPAM-BIS-MA beads while being partially incorporated into pNIPAM-PS network. Cell culture studies demonstrate that the fluorescent composites show non-specific binding to fibroblasts. These features may be very valuable to develop materials for drug delivery and specific targeting of cells combined with the outstanding optical properties of semiconductor nanoparticles as fluorescent labelers.", publisher = "Royal Soc Chemistry, Cambridge", journal = "Journal of Materials Chemistry", title = "CdSe/CdS nanoparticles immobilized on pNIPAm-based microspheres", pages = "1374-1367", number = "7", volume = "20", doi = "10.1039/b917022g" }
Salcher, A., Nikolić, M., Casado, S., Velez, M., Weller, H.,& Juarez, B. H.. (2010). CdSe/CdS nanoparticles immobilized on pNIPAm-based microspheres. in Journal of Materials Chemistry Royal Soc Chemistry, Cambridge., 20(7), 1367-1374. https://doi.org/10.1039/b917022g
Salcher A, Nikolić M, Casado S, Velez M, Weller H, Juarez BH. CdSe/CdS nanoparticles immobilized on pNIPAm-based microspheres. in Journal of Materials Chemistry. 2010;20(7):1367-1374. doi:10.1039/b917022g .
Salcher, Andrea, Nikolić, Marija, Casado, Santiago, Velez, Marisela, Weller, Horst, Juarez, Beatriz H., "CdSe/CdS nanoparticles immobilized on pNIPAm-based microspheres" in Journal of Materials Chemistry, 20, no. 7 (2010):1367-1374, https://doi.org/10.1039/b917022g . .