The oxidative behavior of antibiotic roxithromycin standard was studied at a gold electrode in 0.05 M NaHCO3 using cyclic linear sweep voltammetry and differential pulse voltammetry. It was found that the value of the oxidative peak of pure roxithromycin at 0.81 V vs. SCE in 0.05 M NaHCO3 at a scan rate of 50 mV s(-1) is a linear function of the concentration in a range 0.10006-0.654 mg cm(-3). It was also found that peak current density at 0.75 V vs. SCE at a scan rate of 2 mVs(-1), pulse amplitude of 25 mV and pulse time of 0.1 s exhibits linear dependence on the concentration of roxithromycin from 0.1006 to 0.476 mg cm(-3). Roxithromycin as a content of solid dosage form and urine was quantitatively determined and the obtained results were checked by HPLC.
TY - JOUR
AU - Drljević-Đurić, Katica
AU - Jović, Vladimir D.
AU - Lačnjevac, Uroš
AU - Avramov-Ivić, Milka
AU - Petrović, Slobodan
AU - Mijin, Dušan
AU - Đorđević, S. B.
PY - 2010
UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1718
AB - The oxidative behavior of antibiotic roxithromycin standard was studied at a gold electrode in 0.05 M NaHCO3 using cyclic linear sweep voltammetry and differential pulse voltammetry. It was found that the value of the oxidative peak of pure roxithromycin at 0.81 V vs. SCE in 0.05 M NaHCO3 at a scan rate of 50 mV s(-1) is a linear function of the concentration in a range 0.10006-0.654 mg cm(-3). It was also found that peak current density at 0.75 V vs. SCE at a scan rate of 2 mVs(-1), pulse amplitude of 25 mV and pulse time of 0.1 s exhibits linear dependence on the concentration of roxithromycin from 0.1006 to 0.476 mg cm(-3). Roxithromycin as a content of solid dosage form and urine was quantitatively determined and the obtained results were checked by HPLC.
PB - Pergamon-Elsevier Science Ltd, Oxford
T2 - Electrochimica Acta
T1 - Voltammetric and differential pulse determination of roxithromycin
EP - 52
IS - 1
SP - 47
VL - 56
DO - 10.1016/j.electacta.2010.09.067
ER -
@article{
author = "Drljević-Đurić, Katica and Jović, Vladimir D. and Lačnjevac, Uroš and Avramov-Ivić, Milka and Petrović, Slobodan and Mijin, Dušan and Đorđević, S. B.",
year = "2010",
abstract = "The oxidative behavior of antibiotic roxithromycin standard was studied at a gold electrode in 0.05 M NaHCO3 using cyclic linear sweep voltammetry and differential pulse voltammetry. It was found that the value of the oxidative peak of pure roxithromycin at 0.81 V vs. SCE in 0.05 M NaHCO3 at a scan rate of 50 mV s(-1) is a linear function of the concentration in a range 0.10006-0.654 mg cm(-3). It was also found that peak current density at 0.75 V vs. SCE at a scan rate of 2 mVs(-1), pulse amplitude of 25 mV and pulse time of 0.1 s exhibits linear dependence on the concentration of roxithromycin from 0.1006 to 0.476 mg cm(-3). Roxithromycin as a content of solid dosage form and urine was quantitatively determined and the obtained results were checked by HPLC.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Electrochimica Acta",
title = "Voltammetric and differential pulse determination of roxithromycin",
pages = "52-47",
number = "1",
volume = "56",
doi = "10.1016/j.electacta.2010.09.067"
}
Drljević-Đurić, K., Jović, V. D., Lačnjevac, U., Avramov-Ivić, M., Petrović, S., Mijin, D.,& Đorđević, S. B.. (2010). Voltammetric and differential pulse determination of roxithromycin. in Electrochimica Acta
Pergamon-Elsevier Science Ltd, Oxford., 56(1), 47-52.
https://doi.org/10.1016/j.electacta.2010.09.067
Drljević-Đurić K, Jović VD, Lačnjevac U, Avramov-Ivić M, Petrović S, Mijin D, Đorđević SB. Voltammetric and differential pulse determination of roxithromycin. in Electrochimica Acta. 2010;56(1):47-52.
doi:10.1016/j.electacta.2010.09.067 .
Drljević-Đurić, Katica, Jović, Vladimir D., Lačnjevac, Uroš, Avramov-Ivić, Milka, Petrović, Slobodan, Mijin, Dušan, Đorđević, S. B., "Voltammetric and differential pulse determination of roxithromycin" in Electrochimica Acta, 56, no. 1 (2010):47-52,
https://doi.org/10.1016/j.electacta.2010.09.067 . .
