The influence of starting material properties on physical characteristics and drug release kinetics of poly-L-lactide microcapsules was investigated. The density, the distribution of the diameter size of microcapsules, the voidage and the active substance (methylene blue and Sudan III tracers) released concentrations, in paralel with microcapsules structure were studied. It was found that the density, size and structure of the microcapsules influenced in the polymer molar weight. In the case of the voidage, it exist the influence of the tracer and the polymer molar weight. The kinetic studies showed that the release patterns were similar and controllable. It was concluded that PLLA microcapsules showed a great potential for utilization in the active substance administration.
Keywords:
controlled drug release / microcapsules / polylactide / tracer / Sudan III / polymer kinetics / polymer characterization
Source:
Advanced Materials and Processes: Yucomat II, 1998, 282-2, 271-280
TY - JOUR
AU - Plavšić, Milenko B.
AU - Tomić, S
AU - Sajc, L.
AU - Bugarski, Branko
AU - Jovanović, G
PY - 1998
UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/180
AB - The influence of starting material properties on physical characteristics and drug release kinetics of poly-L-lactide microcapsules was investigated. The density, the distribution of the diameter size of microcapsules, the voidage and the active substance (methylene blue and Sudan III tracers) released concentrations, in paralel with microcapsules structure were studied. It was found that the density, size and structure of the microcapsules influenced in the polymer molar weight. In the case of the voidage, it exist the influence of the tracer and the polymer molar weight. The kinetic studies showed that the release patterns were similar and controllable. It was concluded that PLLA microcapsules showed a great potential for utilization in the active substance administration.
PB - Trans Tech Publications Ltd, Durnten-Zurich
T2 - Advanced Materials and Processes: Yucomat II
T1 - Structure optimization of polylactide microcapsules for controlled drug release
EP - 280
SP - 271
VL - 282-2
DO - 10.4028/www.scientific.net/MSF.282-283.271
ER -
@article{
author = "Plavšić, Milenko B. and Tomić, S and Sajc, L. and Bugarski, Branko and Jovanović, G",
year = "1998",
abstract = "The influence of starting material properties on physical characteristics and drug release kinetics of poly-L-lactide microcapsules was investigated. The density, the distribution of the diameter size of microcapsules, the voidage and the active substance (methylene blue and Sudan III tracers) released concentrations, in paralel with microcapsules structure were studied. It was found that the density, size and structure of the microcapsules influenced in the polymer molar weight. In the case of the voidage, it exist the influence of the tracer and the polymer molar weight. The kinetic studies showed that the release patterns were similar and controllable. It was concluded that PLLA microcapsules showed a great potential for utilization in the active substance administration.",
publisher = "Trans Tech Publications Ltd, Durnten-Zurich",
journal = "Advanced Materials and Processes: Yucomat II",
title = "Structure optimization of polylactide microcapsules for controlled drug release",
pages = "280-271",
volume = "282-2",
doi = "10.4028/www.scientific.net/MSF.282-283.271"
}
Plavšić, M. B., Tomić, S., Sajc, L., Bugarski, B.,& Jovanović, G.. (1998). Structure optimization of polylactide microcapsules for controlled drug release. in Advanced Materials and Processes: Yucomat II
Trans Tech Publications Ltd, Durnten-Zurich., 282-2, 271-280.
https://doi.org/10.4028/www.scientific.net/MSF.282-283.271
Plavšić MB, Tomić S, Sajc L, Bugarski B, Jovanović G. Structure optimization of polylactide microcapsules for controlled drug release. in Advanced Materials and Processes: Yucomat II. 1998;282-2:271-280.
doi:10.4028/www.scientific.net/MSF.282-283.271 .
Plavšić, Milenko B., Tomić, S, Sajc, L., Bugarski, Branko, Jovanović, G, "Structure optimization of polylactide microcapsules for controlled drug release" in Advanced Materials and Processes: Yucomat II, 282-2 (1998):271-280,
https://doi.org/10.4028/www.scientific.net/MSF.282-283.271 . .
