Hydrogels are three-dimensional cross-linked hydrophilic polymers that swell in water and aqueous solutions without dissolving in them. They are very sensitive to environmental stimulus, which is manifested by a sharp phase transition. This feature is important for their application in the pharmaceutical field, especially for making formulations with controlled release of active ingredients, with the correction of the solubility, degradation and their toxicity reducing. Because of the compatibility with living tissues, hydrogels can be used in different medical purposes (for making contact lenses, stents, balloon catheters, artificial muscles, substitutes for arteries and veins, trachea, oviduct). This work presents methods (chemical and physical) for obtaining hydrogels, their properties and sensitivity to environmental stimuli (temperature, pH, magnetic field), as well as their potential application in medicine and pharmacy.
Hidrogelovi su umreženi trodimenzionalni hidrofilni polimeri koji bubre u vodi i vodenim rastvorima, a sami se ne rastvaraju u njima. Jako su osetljivi na spoljne stimulanse, što se manifestuje oštrim faznim prelazom. Ova osobina je važna za njihovu primenu u oblasti farmacije, i to pre svega za izradu formulacija sa kontrolisanim oslobađanjem aktivnih principa, uz korigovanje rastvorljivosti, degradacije i smanjenja njihove toksičnosti. Zahvaljujući kompatibilnosti sa živim tkivima, primena hidrogelova je važna i za rešavanje različitih medicinskih potreba (za izradu kontaktnih sočiva, stentova, balon katetera, veštačkih mišića, zamena za arterije i vene, traheja, jajovoda). U radu su detaljno prikazane metode za njihovo dobijanje (hemijske i fizičke), svojstva i osetljivost na spoljne stimulanse (temperatura, pH, magnetno polje), kao i moguće primene u oblasti medicine i farmacije.
Keywords:
hydrogels / intelligent gels / drug delivery systems / cross-linking / N-isopropylacrilamide / hidrogelovi / inteligentni gelovi / sistemi oslobađanja lekova / umrežavanje / N-izopropilakrilamid
Source:
Facta universitatis - series: Physics, Chemistry and Technology, 2011, 9, 1, 37-56
TY - JOUR
AU - Ilić-Stojanović, Snežana
AU - Nikolić, Ljubiša B.
AU - Nikolić, Vesna
AU - Petrović, Slobodan
AU - Stanković, Mihajlo
AU - Mladenović-Ranisavljević, Ivana
PY - 2011
UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1837
AB - Hydrogels are three-dimensional cross-linked hydrophilic polymers that swell in water and aqueous solutions without dissolving in them. They are very sensitive to environmental stimulus, which is manifested by a sharp phase transition. This feature is important for their application in the pharmaceutical field, especially for making formulations with controlled release of active ingredients, with the correction of the solubility, degradation and their toxicity reducing. Because of the compatibility with living tissues, hydrogels can be used in different medical purposes (for making contact lenses, stents, balloon catheters, artificial muscles, substitutes for arteries and veins, trachea, oviduct). This work presents methods (chemical and physical) for obtaining hydrogels, their properties and sensitivity to environmental stimuli (temperature, pH, magnetic field), as well as their potential application in medicine and pharmacy.
AB - Hidrogelovi su umreženi trodimenzionalni hidrofilni polimeri koji bubre u vodi i vodenim rastvorima, a sami se ne rastvaraju u njima. Jako su osetljivi na spoljne stimulanse, što se manifestuje oštrim faznim prelazom. Ova osobina je važna za njihovu primenu u oblasti farmacije, i to pre svega za izradu formulacija sa kontrolisanim oslobađanjem aktivnih principa, uz korigovanje rastvorljivosti, degradacije i smanjenja njihove toksičnosti. Zahvaljujući kompatibilnosti sa živim tkivima, primena hidrogelova je važna i za rešavanje različitih medicinskih potreba (za izradu kontaktnih sočiva, stentova, balon katetera, veštačkih mišića, zamena za arterije i vene, traheja, jajovoda). U radu su detaljno prikazane metode za njihovo dobijanje (hemijske i fizičke), svojstva i osetljivost na spoljne stimulanse (temperatura, pH, magnetno polje), kao i moguće primene u oblasti medicine i farmacije.
PB - Univerzitet u Nišu, Niš
T2 - Facta universitatis - series: Physics, Chemistry and Technology
T1 - Stimuli-sensitive hydrogels for pharmaceutical and medical applications
T1 - Hidrogelovi osetljivi na spoljne stimulanse za farmaceutsku i medicinsku primenu
EP - 56
IS - 1
SP - 37
VL - 9
DO - 10.2298/FUPCT1101037I
ER -
@article{
author = "Ilić-Stojanović, Snežana and Nikolić, Ljubiša B. and Nikolić, Vesna and Petrović, Slobodan and Stanković, Mihajlo and Mladenović-Ranisavljević, Ivana",
year = "2011",
abstract = "Hydrogels are three-dimensional cross-linked hydrophilic polymers that swell in water and aqueous solutions without dissolving in them. They are very sensitive to environmental stimulus, which is manifested by a sharp phase transition. This feature is important for their application in the pharmaceutical field, especially for making formulations with controlled release of active ingredients, with the correction of the solubility, degradation and their toxicity reducing. Because of the compatibility with living tissues, hydrogels can be used in different medical purposes (for making contact lenses, stents, balloon catheters, artificial muscles, substitutes for arteries and veins, trachea, oviduct). This work presents methods (chemical and physical) for obtaining hydrogels, their properties and sensitivity to environmental stimuli (temperature, pH, magnetic field), as well as their potential application in medicine and pharmacy., Hidrogelovi su umreženi trodimenzionalni hidrofilni polimeri koji bubre u vodi i vodenim rastvorima, a sami se ne rastvaraju u njima. Jako su osetljivi na spoljne stimulanse, što se manifestuje oštrim faznim prelazom. Ova osobina je važna za njihovu primenu u oblasti farmacije, i to pre svega za izradu formulacija sa kontrolisanim oslobađanjem aktivnih principa, uz korigovanje rastvorljivosti, degradacije i smanjenja njihove toksičnosti. Zahvaljujući kompatibilnosti sa živim tkivima, primena hidrogelova je važna i za rešavanje različitih medicinskih potreba (za izradu kontaktnih sočiva, stentova, balon katetera, veštačkih mišića, zamena za arterije i vene, traheja, jajovoda). U radu su detaljno prikazane metode za njihovo dobijanje (hemijske i fizičke), svojstva i osetljivost na spoljne stimulanse (temperatura, pH, magnetno polje), kao i moguće primene u oblasti medicine i farmacije.",
publisher = "Univerzitet u Nišu, Niš",
journal = "Facta universitatis - series: Physics, Chemistry and Technology",
title = "Stimuli-sensitive hydrogels for pharmaceutical and medical applications, Hidrogelovi osetljivi na spoljne stimulanse za farmaceutsku i medicinsku primenu",
pages = "56-37",
number = "1",
volume = "9",
doi = "10.2298/FUPCT1101037I"
}
Ilić-Stojanović, S., Nikolić, L. B., Nikolić, V., Petrović, S., Stanković, M.,& Mladenović-Ranisavljević, I.. (2011). Stimuli-sensitive hydrogels for pharmaceutical and medical applications. in Facta universitatis - series: Physics, Chemistry and Technology
Univerzitet u Nišu, Niš., 9(1), 37-56.
https://doi.org/10.2298/FUPCT1101037I
Ilić-Stojanović S, Nikolić LB, Nikolić V, Petrović S, Stanković M, Mladenović-Ranisavljević I. Stimuli-sensitive hydrogels for pharmaceutical and medical applications. in Facta universitatis - series: Physics, Chemistry and Technology. 2011;9(1):37-56.
doi:10.2298/FUPCT1101037I .
Ilić-Stojanović, Snežana, Nikolić, Ljubiša B., Nikolić, Vesna, Petrović, Slobodan, Stanković, Mihajlo, Mladenović-Ranisavljević, Ivana, "Stimuli-sensitive hydrogels for pharmaceutical and medical applications" in Facta universitatis - series: Physics, Chemistry and Technology, 9, no. 1 (2011):37-56,
https://doi.org/10.2298/FUPCT1101037I . .
