Evaluation of the Lipophilicity and Prediction of Biological Activity of Some N-Cyclohexyl-N-Substituted-2-Phenylacetamide Derivatives Using RP-TLC
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2011
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The chromatographic behavior of N-cyclohexyl-N-substituted-2-phenylacetamides was investigated using reversed phase thin-layer chromatography (RP-TLC). RP-TLC was performed on a C-18 bonded phase with different aqueous eluents: water-acetone, water-acetonitrile and water dioxane. Linear relationship between retention parameters and organic modifier content in the mobile phase allows the extrapolation procedure. From results, it is evident that retention behavior of investigated compound depended on structures of substituents R. The correlation between the chromatographic lipophilic parameters (R-M(0)) and calculated log P values and several pharmacokinetics parameters such as HIA (human intestinal absorption) predictor, the plasma protein binding (PB) predictor, and partition predictor for predicting the biological activity of the blood-brain barrier (BBB) has been studied. The results show that reversed-phase R-M(0) proved to express lipophilic nature of investigated compounds as well... as biological activity.
Ključne reči:
N-cyclohexyl-N-substituted-2-phenylacetamide / RP-C-18 TLC / LipophilicityIzvor:
JPC-Journal of Planar Chromatography-Modern Tlc, 2011, 24, 5, 435-440Izdavač:
- Akademiai Kiado Zrt, Budapest
Finansiranje / projekti:
- Proučavanje sinteze, strukture i aktivnosti organskih jedinjenja prirodnog i sintetskog porekla (RS-172013)
DOI: 10.1556/JPC.24.2011.5.13
ISSN: 0933-4173
WoS: 000296269900014
Scopus: 2-s2.0-80054926399
Institucija/grupa
Tehnološko-metalurški fakultetTY - JOUR AU - Vaštag, Đenđi AU - Perišić-Janjić, Nada AU - Tomić, Jelena AU - Petrović, Slobodan PY - 2011 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1858 AB - The chromatographic behavior of N-cyclohexyl-N-substituted-2-phenylacetamides was investigated using reversed phase thin-layer chromatography (RP-TLC). RP-TLC was performed on a C-18 bonded phase with different aqueous eluents: water-acetone, water-acetonitrile and water dioxane. Linear relationship between retention parameters and organic modifier content in the mobile phase allows the extrapolation procedure. From results, it is evident that retention behavior of investigated compound depended on structures of substituents R. The correlation between the chromatographic lipophilic parameters (R-M(0)) and calculated log P values and several pharmacokinetics parameters such as HIA (human intestinal absorption) predictor, the plasma protein binding (PB) predictor, and partition predictor for predicting the biological activity of the blood-brain barrier (BBB) has been studied. The results show that reversed-phase R-M(0) proved to express lipophilic nature of investigated compounds as well as biological activity. PB - Akademiai Kiado Zrt, Budapest T2 - JPC-Journal of Planar Chromatography-Modern Tlc T1 - Evaluation of the Lipophilicity and Prediction of Biological Activity of Some N-Cyclohexyl-N-Substituted-2-Phenylacetamide Derivatives Using RP-TLC EP - 440 IS - 5 SP - 435 VL - 24 DO - 10.1556/JPC.24.2011.5.13 ER -
@article{ author = "Vaštag, Đenđi and Perišić-Janjić, Nada and Tomić, Jelena and Petrović, Slobodan", year = "2011", abstract = "The chromatographic behavior of N-cyclohexyl-N-substituted-2-phenylacetamides was investigated using reversed phase thin-layer chromatography (RP-TLC). RP-TLC was performed on a C-18 bonded phase with different aqueous eluents: water-acetone, water-acetonitrile and water dioxane. Linear relationship between retention parameters and organic modifier content in the mobile phase allows the extrapolation procedure. From results, it is evident that retention behavior of investigated compound depended on structures of substituents R. The correlation between the chromatographic lipophilic parameters (R-M(0)) and calculated log P values and several pharmacokinetics parameters such as HIA (human intestinal absorption) predictor, the plasma protein binding (PB) predictor, and partition predictor for predicting the biological activity of the blood-brain barrier (BBB) has been studied. The results show that reversed-phase R-M(0) proved to express lipophilic nature of investigated compounds as well as biological activity.", publisher = "Akademiai Kiado Zrt, Budapest", journal = "JPC-Journal of Planar Chromatography-Modern Tlc", title = "Evaluation of the Lipophilicity and Prediction of Biological Activity of Some N-Cyclohexyl-N-Substituted-2-Phenylacetamide Derivatives Using RP-TLC", pages = "440-435", number = "5", volume = "24", doi = "10.1556/JPC.24.2011.5.13" }
Vaštag, Đ., Perišić-Janjić, N., Tomić, J.,& Petrović, S.. (2011). Evaluation of the Lipophilicity and Prediction of Biological Activity of Some N-Cyclohexyl-N-Substituted-2-Phenylacetamide Derivatives Using RP-TLC. in JPC-Journal of Planar Chromatography-Modern Tlc Akademiai Kiado Zrt, Budapest., 24(5), 435-440. https://doi.org/10.1556/JPC.24.2011.5.13
Vaštag Đ, Perišić-Janjić N, Tomić J, Petrović S. Evaluation of the Lipophilicity and Prediction of Biological Activity of Some N-Cyclohexyl-N-Substituted-2-Phenylacetamide Derivatives Using RP-TLC. in JPC-Journal of Planar Chromatography-Modern Tlc. 2011;24(5):435-440. doi:10.1556/JPC.24.2011.5.13 .
Vaštag, Đenđi, Perišić-Janjić, Nada, Tomić, Jelena, Petrović, Slobodan, "Evaluation of the Lipophilicity and Prediction of Biological Activity of Some N-Cyclohexyl-N-Substituted-2-Phenylacetamide Derivatives Using RP-TLC" in JPC-Journal of Planar Chromatography-Modern Tlc, 24, no. 5 (2011):435-440, https://doi.org/10.1556/JPC.24.2011.5.13 . .