In this work, the influence of the morphology of hydroxyapatite particles on silicon substitution through hydrothermal synthesis performed under the same conditions was investigated. Spherical- and whisker-like hydroxyapatite particles were obtained starting from calcium-nitrate, sodium dihydrogen phosphate, disodium-ethylenediaminetetraacetic acid and urea (used only for the synthesis of whisker-like particles) dissolved in aqueous solutions. Silicon was introduced into the solution using tetraethylorthosilicate. X-ray diffraction, infrared spectroscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy and transmission electron microscopy indicate that silicon doping induce different phase compositions and bioactivity of spherical- and whisker-like hydroxyapatite particles obtained under the same hydrothermal conditions. Silicon-substituted, spherical hydroxyapatites particles showed greater phase transformation to silicon-substituted alpha- calcium-phosphate compare...d with whiskers-like hydroxyapatite particles synthesized with the same amount of added silicon. Metabolic activity assay performed with SaOs2 osteosarcoma cells showed better biocompatibility of annealed biphasic spherical-like particles compared with annealed whiskerlike particles while dried spherical-like particles induce high cytotoxicity effect.
Source:
Journal of Materials Science-Materials in Medicine, 2011, 22, 10, 2175-2185
TY - JOUR
AU - Jokić, Bojan
AU - Mitrić, Miodrag
AU - Popović, Maja
AU - Sima, L.
AU - Petrescu, S. M.
AU - Petrović, Rada
AU - Janaćković, Đorđe
PY - 2011
UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1863
AB - In this work, the influence of the morphology of hydroxyapatite particles on silicon substitution through hydrothermal synthesis performed under the same conditions was investigated. Spherical- and whisker-like hydroxyapatite particles were obtained starting from calcium-nitrate, sodium dihydrogen phosphate, disodium-ethylenediaminetetraacetic acid and urea (used only for the synthesis of whisker-like particles) dissolved in aqueous solutions. Silicon was introduced into the solution using tetraethylorthosilicate. X-ray diffraction, infrared spectroscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy and transmission electron microscopy indicate that silicon doping induce different phase compositions and bioactivity of spherical- and whisker-like hydroxyapatite particles obtained under the same hydrothermal conditions. Silicon-substituted, spherical hydroxyapatites particles showed greater phase transformation to silicon-substituted alpha- calcium-phosphate compared with whiskers-like hydroxyapatite particles synthesized with the same amount of added silicon. Metabolic activity assay performed with SaOs2 osteosarcoma cells showed better biocompatibility of annealed biphasic spherical-like particles compared with annealed whiskerlike particles while dried spherical-like particles induce high cytotoxicity effect.
PB - Springer, Dordrecht
T2 - Journal of Materials Science-Materials in Medicine
T1 - The influence of silicon substitution on the properties of spherical- and whisker-like biphasic alpha-calcium-phosphate/hydroxyapatite particles
EP - 2185
IS - 10
SP - 2175
VL - 22
DO - 10.1007/s10856-011-4412-6
ER -
@article{
author = "Jokić, Bojan and Mitrić, Miodrag and Popović, Maja and Sima, L. and Petrescu, S. M. and Petrović, Rada and Janaćković, Đorđe",
year = "2011",
abstract = "In this work, the influence of the morphology of hydroxyapatite particles on silicon substitution through hydrothermal synthesis performed under the same conditions was investigated. Spherical- and whisker-like hydroxyapatite particles were obtained starting from calcium-nitrate, sodium dihydrogen phosphate, disodium-ethylenediaminetetraacetic acid and urea (used only for the synthesis of whisker-like particles) dissolved in aqueous solutions. Silicon was introduced into the solution using tetraethylorthosilicate. X-ray diffraction, infrared spectroscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy and transmission electron microscopy indicate that silicon doping induce different phase compositions and bioactivity of spherical- and whisker-like hydroxyapatite particles obtained under the same hydrothermal conditions. Silicon-substituted, spherical hydroxyapatites particles showed greater phase transformation to silicon-substituted alpha- calcium-phosphate compared with whiskers-like hydroxyapatite particles synthesized with the same amount of added silicon. Metabolic activity assay performed with SaOs2 osteosarcoma cells showed better biocompatibility of annealed biphasic spherical-like particles compared with annealed whiskerlike particles while dried spherical-like particles induce high cytotoxicity effect.",
publisher = "Springer, Dordrecht",
journal = "Journal of Materials Science-Materials in Medicine",
title = "The influence of silicon substitution on the properties of spherical- and whisker-like biphasic alpha-calcium-phosphate/hydroxyapatite particles",
pages = "2185-2175",
number = "10",
volume = "22",
doi = "10.1007/s10856-011-4412-6"
}
Jokić, B., Mitrić, M., Popović, M., Sima, L., Petrescu, S. M., Petrović, R.,& Janaćković, Đ.. (2011). The influence of silicon substitution on the properties of spherical- and whisker-like biphasic alpha-calcium-phosphate/hydroxyapatite particles. in Journal of Materials Science-Materials in Medicine
Springer, Dordrecht., 22(10), 2175-2185.
https://doi.org/10.1007/s10856-011-4412-6
Jokić B, Mitrić M, Popović M, Sima L, Petrescu SM, Petrović R, Janaćković Đ. The influence of silicon substitution on the properties of spherical- and whisker-like biphasic alpha-calcium-phosphate/hydroxyapatite particles. in Journal of Materials Science-Materials in Medicine. 2011;22(10):2175-2185.
doi:10.1007/s10856-011-4412-6 .
Jokić, Bojan, Mitrić, Miodrag, Popović, Maja, Sima, L., Petrescu, S. M., Petrović, Rada, Janaćković, Đorđe, "The influence of silicon substitution on the properties of spherical- and whisker-like biphasic alpha-calcium-phosphate/hydroxyapatite particles" in Journal of Materials Science-Materials in Medicine, 22, no. 10 (2011):2175-2185,
https://doi.org/10.1007/s10856-011-4412-6 . .
