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dc.creatorMilosavljević, Nedeljko
dc.creatorMilašinović, Nikola
dc.creatorPopović, Ivanka
dc.creatorFilipović, Jovanka M.
dc.creatorKalagasidis Krušić, Melina
dc.date.accessioned2021-03-10T11:36:27Z
dc.date.available2021-03-10T11:36:27Z
dc.date.issued2011
dc.identifier.issn0959-8103
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/1908
dc.description.abstractNovel pH-sensitive hydrogels based on chitosan, itaconic acid and methacrylic acid were prepared in two steps. Chitosan was first ionically crosslinked with itaconic acid, after which a free radical polymerization and crosslinking of the chitosan/itaconic acid network was performed by adding methacrylic acid and a crosslinker in order to achieve better mechanical properties and tunable swelling. The samples were characterized using Fourier transform infrared spectroscopy, scanning electron microscopy, thermogravimetric analysis, X-ray diffraction, dynamic mechanical analysis and the swelling ratios of the hydrogels at various pH values (2.0-8.0). The hydrogel composition is found to have a great impact on the hydrogel structure, mechanical and thermal properties, morphology and swelling kinetics. The highly porous morphology of the gels is probably connected with the bulky chitosan/itaconic acid network which reduces the degree of crosslinking in the second step of the synthesis due to steric hindrances. The gels demonstrate substantial change in buffer absorbency with change of pH, low for acid buffers and the higher for pH values above 6 where the swelling is considerably slow, thus suggesting their strong candidature for use as oral drug-delivery systems in the lower parts of the gastrointestinal tract and for drugs that require longer release times.en
dc.publisherWiley-Blackwell, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142023/RS//
dc.rightsrestrictedAccess
dc.sourcePolymer International
dc.subjectchitosanen
dc.subjectitaconic aciden
dc.subjecthydrogelsen
dc.subjectmethacrylic aciden
dc.subjectradical polymerizationen
dc.titlePreparation and characterization of pH-sensitive hydrogels based on chitosan, itaconic acid and methacrylic aciden
dc.typearticle
dc.rights.licenseARR
dc.citation.epage452
dc.citation.issue3
dc.citation.other60(3): 443-452
dc.citation.rankM22
dc.citation.spage443
dc.citation.volume60
dc.identifier.doi10.1002/pi.2967
dc.identifier.scopus2-s2.0-79751494480
dc.identifier.wos000288133700014
dc.type.versionpublishedVersion


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