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Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides

Authorized Users Only
2011
Authors
Aljančić, Ivana
Pešić, Milica
Milosavljević, Slobodan M.
Todorović, Nina
Jadranin, Milka
Miosavljević, Goran
Povrenović, Dragan
Banković, Jasna
Tanić, Nikola
Marković, Ivanka
Ruzdijić, Sabera
Vajs, Vlatka
Tešević, Vele
Article (Published version)
Metadata
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Abstract
From the Montenegrin spurge Euphorbia dendroides, seven new diterpenoids [jatrophanes (1-6) and a tigliane (7)] were isolated and their structures elucidated by spectroscopic techniques. The biological activity of the new compounds was studied against four human cancer cell lines. The most effective jatrophane-type compound (2) and its structurally closely related derivative (1) were evaluated for their interactions with paclitaxel and doxorubicin using a multidrug-resistant cancer cell line. Both compounds exerted a strong reversal potential resulting from inhibition of P-glycoprotein transport.
Source:
Journal of Natural Products, 2011, 74, 7, 1613-1620
Publisher:
  • Amer Chemical Soc, Washington
Funding / projects:
  • Natural products of wild, cultivated and edible plants: structure and bioactivity determination (RS-172053)
  • Identification of predictive molecular markers for cancer progression, response to therapy and disease outcome (RS-41031)

DOI: 10.1021/np200241c

ISSN: 0163-3864

PubMed: 21707046

WoS: 000293036100009

Scopus: 2-s2.0-79960728011
[ Google Scholar ]
54
44
URI
http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1943
Collections
  • Radovi istraživača / Researchers’ publications (TMF)
Institution/Community
Tehnološko-metalurški fakultet
TY  - JOUR
AU  - Aljančić, Ivana
AU  - Pešić, Milica
AU  - Milosavljević, Slobodan M.
AU  - Todorović, Nina
AU  - Jadranin, Milka
AU  - Miosavljević, Goran
AU  - Povrenović, Dragan
AU  - Banković, Jasna
AU  - Tanić, Nikola
AU  - Marković, Ivanka
AU  - Ruzdijić, Sabera
AU  - Vajs, Vlatka
AU  - Tešević, Vele
PY  - 2011
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1943
AB  - From the Montenegrin spurge Euphorbia dendroides, seven new diterpenoids [jatrophanes (1-6) and a tigliane (7)] were isolated and their structures elucidated by spectroscopic techniques. The biological activity of the new compounds was studied against four human cancer cell lines. The most effective jatrophane-type compound (2) and its structurally closely related derivative (1) were evaluated for their interactions with paclitaxel and doxorubicin using a multidrug-resistant cancer cell line. Both compounds exerted a strong reversal potential resulting from inhibition of P-glycoprotein transport.
PB  - Amer Chemical Soc, Washington
T2  - Journal of Natural Products
T1  - Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides
EP  - 1620
IS  - 7
SP  - 1613
VL  - 74
DO  - 10.1021/np200241c
ER  - 
@article{
author = "Aljančić, Ivana and Pešić, Milica and Milosavljević, Slobodan M. and Todorović, Nina and Jadranin, Milka and Miosavljević, Goran and Povrenović, Dragan and Banković, Jasna and Tanić, Nikola and Marković, Ivanka and Ruzdijić, Sabera and Vajs, Vlatka and Tešević, Vele",
year = "2011",
abstract = "From the Montenegrin spurge Euphorbia dendroides, seven new diterpenoids [jatrophanes (1-6) and a tigliane (7)] were isolated and their structures elucidated by spectroscopic techniques. The biological activity of the new compounds was studied against four human cancer cell lines. The most effective jatrophane-type compound (2) and its structurally closely related derivative (1) were evaluated for their interactions with paclitaxel and doxorubicin using a multidrug-resistant cancer cell line. Both compounds exerted a strong reversal potential resulting from inhibition of P-glycoprotein transport.",
publisher = "Amer Chemical Soc, Washington",
journal = "Journal of Natural Products",
title = "Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides",
pages = "1620-1613",
number = "7",
volume = "74",
doi = "10.1021/np200241c"
}
Aljančić, I., Pešić, M., Milosavljević, S. M., Todorović, N., Jadranin, M., Miosavljević, G., Povrenović, D., Banković, J., Tanić, N., Marković, I., Ruzdijić, S., Vajs, V.,& Tešević, V.. (2011). Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides. in Journal of Natural Products
Amer Chemical Soc, Washington., 74(7), 1613-1620.
https://doi.org/10.1021/np200241c
Aljančić I, Pešić M, Milosavljević SM, Todorović N, Jadranin M, Miosavljević G, Povrenović D, Banković J, Tanić N, Marković I, Ruzdijić S, Vajs V, Tešević V. Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides. in Journal of Natural Products. 2011;74(7):1613-1620.
doi:10.1021/np200241c .
Aljančić, Ivana, Pešić, Milica, Milosavljević, Slobodan M., Todorović, Nina, Jadranin, Milka, Miosavljević, Goran, Povrenović, Dragan, Banković, Jasna, Tanić, Nikola, Marković, Ivanka, Ruzdijić, Sabera, Vajs, Vlatka, Tešević, Vele, "Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides" in Journal of Natural Products, 74, no. 7 (2011):1613-1620,
https://doi.org/10.1021/np200241c . .

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