From the Montenegrin spurge Euphorbia dendroides, seven new diterpenoids [jatrophanes (1-6) and a tigliane (7)] were isolated and their structures elucidated by spectroscopic techniques. The biological activity of the new compounds was studied against four human cancer cell lines. The most effective jatrophane-type compound (2) and its structurally closely related derivative (1) were evaluated for their interactions with paclitaxel and doxorubicin using a multidrug-resistant cancer cell line. Both compounds exerted a strong reversal potential resulting from inhibition of P-glycoprotein transport.
Source:
Journal of Natural Products, 2011, 74, 7, 1613-1620
TY - JOUR
AU - Aljančić, Ivana
AU - Pešić, Milica
AU - Milosavljević, Slobodan M.
AU - Todorović, Nina
AU - Jadranin, Milka
AU - Miosavljević, Goran
AU - Povrenović, Dragan
AU - Banković, Jasna
AU - Tanić, Nikola
AU - Marković, Ivanka
AU - Ruzdijić, Sabera
AU - Vajs, Vlatka
AU - Tešević, Vele
PY - 2011
UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1943
AB - From the Montenegrin spurge Euphorbia dendroides, seven new diterpenoids [jatrophanes (1-6) and a tigliane (7)] were isolated and their structures elucidated by spectroscopic techniques. The biological activity of the new compounds was studied against four human cancer cell lines. The most effective jatrophane-type compound (2) and its structurally closely related derivative (1) were evaluated for their interactions with paclitaxel and doxorubicin using a multidrug-resistant cancer cell line. Both compounds exerted a strong reversal potential resulting from inhibition of P-glycoprotein transport.
PB - Amer Chemical Soc, Washington
T2 - Journal of Natural Products
T1 - Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides
EP - 1620
IS - 7
SP - 1613
VL - 74
DO - 10.1021/np200241c
ER -
@article{
author = "Aljančić, Ivana and Pešić, Milica and Milosavljević, Slobodan M. and Todorović, Nina and Jadranin, Milka and Miosavljević, Goran and Povrenović, Dragan and Banković, Jasna and Tanić, Nikola and Marković, Ivanka and Ruzdijić, Sabera and Vajs, Vlatka and Tešević, Vele",
year = "2011",
abstract = "From the Montenegrin spurge Euphorbia dendroides, seven new diterpenoids [jatrophanes (1-6) and a tigliane (7)] were isolated and their structures elucidated by spectroscopic techniques. The biological activity of the new compounds was studied against four human cancer cell lines. The most effective jatrophane-type compound (2) and its structurally closely related derivative (1) were evaluated for their interactions with paclitaxel and doxorubicin using a multidrug-resistant cancer cell line. Both compounds exerted a strong reversal potential resulting from inhibition of P-glycoprotein transport.",
publisher = "Amer Chemical Soc, Washington",
journal = "Journal of Natural Products",
title = "Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides",
pages = "1620-1613",
number = "7",
volume = "74",
doi = "10.1021/np200241c"
}
Aljančić, I., Pešić, M., Milosavljević, S. M., Todorović, N., Jadranin, M., Miosavljević, G., Povrenović, D., Banković, J., Tanić, N., Marković, I., Ruzdijić, S., Vajs, V.,& Tešević, V.. (2011). Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides. in Journal of Natural Products
Amer Chemical Soc, Washington., 74(7), 1613-1620.
https://doi.org/10.1021/np200241c
Aljančić I, Pešić M, Milosavljević SM, Todorović N, Jadranin M, Miosavljević G, Povrenović D, Banković J, Tanić N, Marković I, Ruzdijić S, Vajs V, Tešević V. Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides. in Journal of Natural Products. 2011;74(7):1613-1620.
doi:10.1021/np200241c .
Aljančić, Ivana, Pešić, Milica, Milosavljević, Slobodan M., Todorović, Nina, Jadranin, Milka, Miosavljević, Goran, Povrenović, Dragan, Banković, Jasna, Tanić, Nikola, Marković, Ivanka, Ruzdijić, Sabera, Vajs, Vlatka, Tešević, Vele, "Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides" in Journal of Natural Products, 74, no. 7 (2011):1613-1620,
https://doi.org/10.1021/np200241c . .
