Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides
Само за регистроване кориснике
2011
Аутори
Aljančić, IvanaPešić, Milica

Milosavljević, Slobodan M.
Todorović, Nina
Jadranin, Milka

Miosavljević, Goran
Povrenović, Dragan

Banković, Jasna
Tanić, Nikola
Marković, Ivanka

Ruzdijić, Sabera
Vajs, Vlatka
Tešević, Vele

Чланак у часопису (Објављена верзија)

Метаподаци
Приказ свих података о документуАпстракт
From the Montenegrin spurge Euphorbia dendroides, seven new diterpenoids [jatrophanes (1-6) and a tigliane (7)] were isolated and their structures elucidated by spectroscopic techniques. The biological activity of the new compounds was studied against four human cancer cell lines. The most effective jatrophane-type compound (2) and its structurally closely related derivative (1) were evaluated for their interactions with paclitaxel and doxorubicin using a multidrug-resistant cancer cell line. Both compounds exerted a strong reversal potential resulting from inhibition of P-glycoprotein transport.
Извор:
Journal of Natural Products, 2011, 74, 7, 1613-1620Издавач:
- Amer Chemical Soc, Washington
Финансирање / пројекти:
- Биоактивни природни производи самониклих, гајених и јестивих биљака: одређивање структура и активности (RS-172053)
- Идентификација молекуларних маркера за предикцију прогресије тумора, одговора на терапију и исхода болести (RS-41031)
DOI: 10.1021/np200241c
ISSN: 0163-3864
PubMed: 21707046
WoS: 000293036100009
Scopus: 2-s2.0-79960728011
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Aljančić, Ivana AU - Pešić, Milica AU - Milosavljević, Slobodan M. AU - Todorović, Nina AU - Jadranin, Milka AU - Miosavljević, Goran AU - Povrenović, Dragan AU - Banković, Jasna AU - Tanić, Nikola AU - Marković, Ivanka AU - Ruzdijić, Sabera AU - Vajs, Vlatka AU - Tešević, Vele PY - 2011 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1943 AB - From the Montenegrin spurge Euphorbia dendroides, seven new diterpenoids [jatrophanes (1-6) and a tigliane (7)] were isolated and their structures elucidated by spectroscopic techniques. The biological activity of the new compounds was studied against four human cancer cell lines. The most effective jatrophane-type compound (2) and its structurally closely related derivative (1) were evaluated for their interactions with paclitaxel and doxorubicin using a multidrug-resistant cancer cell line. Both compounds exerted a strong reversal potential resulting from inhibition of P-glycoprotein transport. PB - Amer Chemical Soc, Washington T2 - Journal of Natural Products T1 - Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides EP - 1620 IS - 7 SP - 1613 VL - 74 DO - 10.1021/np200241c ER -
@article{ author = "Aljančić, Ivana and Pešić, Milica and Milosavljević, Slobodan M. and Todorović, Nina and Jadranin, Milka and Miosavljević, Goran and Povrenović, Dragan and Banković, Jasna and Tanić, Nikola and Marković, Ivanka and Ruzdijić, Sabera and Vajs, Vlatka and Tešević, Vele", year = "2011", abstract = "From the Montenegrin spurge Euphorbia dendroides, seven new diterpenoids [jatrophanes (1-6) and a tigliane (7)] were isolated and their structures elucidated by spectroscopic techniques. The biological activity of the new compounds was studied against four human cancer cell lines. The most effective jatrophane-type compound (2) and its structurally closely related derivative (1) were evaluated for their interactions with paclitaxel and doxorubicin using a multidrug-resistant cancer cell line. Both compounds exerted a strong reversal potential resulting from inhibition of P-glycoprotein transport.", publisher = "Amer Chemical Soc, Washington", journal = "Journal of Natural Products", title = "Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides", pages = "1620-1613", number = "7", volume = "74", doi = "10.1021/np200241c" }
Aljančić, I., Pešić, M., Milosavljević, S. M., Todorović, N., Jadranin, M., Miosavljević, G., Povrenović, D., Banković, J., Tanić, N., Marković, I., Ruzdijić, S., Vajs, V.,& Tešević, V.. (2011). Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides. in Journal of Natural Products Amer Chemical Soc, Washington., 74(7), 1613-1620. https://doi.org/10.1021/np200241c
Aljančić I, Pešić M, Milosavljević SM, Todorović N, Jadranin M, Miosavljević G, Povrenović D, Banković J, Tanić N, Marković I, Ruzdijić S, Vajs V, Tešević V. Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides. in Journal of Natural Products. 2011;74(7):1613-1620. doi:10.1021/np200241c .
Aljančić, Ivana, Pešić, Milica, Milosavljević, Slobodan M., Todorović, Nina, Jadranin, Milka, Miosavljević, Goran, Povrenović, Dragan, Banković, Jasna, Tanić, Nikola, Marković, Ivanka, Ruzdijić, Sabera, Vajs, Vlatka, Tešević, Vele, "Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides" in Journal of Natural Products, 74, no. 7 (2011):1613-1620, https://doi.org/10.1021/np200241c . .