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Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides

dc.creatorAljančić, Ivana
dc.creatorPešić, Milica
dc.creatorMilosavljević, Slobodan M.
dc.creatorTodorović, Nina
dc.creatorJadranin, Milka
dc.creatorMiosavljević, Goran
dc.creatorPovrenović, Dragan
dc.creatorBanković, Jasna
dc.creatorTanić, Nikola
dc.creatorMarković, Ivanka
dc.creatorRuzdijić, Sabera
dc.creatorVajs, Vlatka
dc.creatorTešević, Vele
dc.date.accessioned2021-03-10T11:38:39Z
dc.date.available2021-03-10T11:38:39Z
dc.date.issued2011
dc.identifier.issn0163-3864
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/1943
dc.description.abstractFrom the Montenegrin spurge Euphorbia dendroides, seven new diterpenoids [jatrophanes (1-6) and a tigliane (7)] were isolated and their structures elucidated by spectroscopic techniques. The biological activity of the new compounds was studied against four human cancer cell lines. The most effective jatrophane-type compound (2) and its structurally closely related derivative (1) were evaluated for their interactions with paclitaxel and doxorubicin using a multidrug-resistant cancer cell line. Both compounds exerted a strong reversal potential resulting from inhibition of P-glycoprotein transport.en
dc.publisherAmer Chemical Soc, Washington
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41031/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Natural Products
dc.titleIsolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroidesen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage1620
dc.citation.issue7
dc.citation.other74(7): 1613-1620
dc.citation.rankM21
dc.citation.spage1613
dc.citation.volume74
dc.identifier.doi10.1021/np200241c
dc.identifier.pmid21707046
dc.identifier.scopus2-s2.0-79960728011
dc.identifier.wos000293036100009
dc.type.versionpublishedVersion


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