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Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides
dc.creator | Aljančić, Ivana | |
dc.creator | Pešić, Milica | |
dc.creator | Milosavljević, Slobodan M. | |
dc.creator | Todorović, Nina | |
dc.creator | Jadranin, Milka | |
dc.creator | Miosavljević, Goran | |
dc.creator | Povrenović, Dragan | |
dc.creator | Banković, Jasna | |
dc.creator | Tanić, Nikola | |
dc.creator | Marković, Ivanka | |
dc.creator | Ruzdijić, Sabera | |
dc.creator | Vajs, Vlatka | |
dc.creator | Tešević, Vele | |
dc.date.accessioned | 2021-03-10T11:38:39Z | |
dc.date.available | 2021-03-10T11:38:39Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 0163-3864 | |
dc.identifier.uri | http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1943 | |
dc.description.abstract | From the Montenegrin spurge Euphorbia dendroides, seven new diterpenoids [jatrophanes (1-6) and a tigliane (7)] were isolated and their structures elucidated by spectroscopic techniques. The biological activity of the new compounds was studied against four human cancer cell lines. The most effective jatrophane-type compound (2) and its structurally closely related derivative (1) were evaluated for their interactions with paclitaxel and doxorubicin using a multidrug-resistant cancer cell line. Both compounds exerted a strong reversal potential resulting from inhibition of P-glycoprotein transport. | en |
dc.publisher | Amer Chemical Soc, Washington | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41031/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of Natural Products | |
dc.title | Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 1620 | |
dc.citation.issue | 7 | |
dc.citation.other | 74(7): 1613-1620 | |
dc.citation.rank | M21 | |
dc.citation.spage | 1613 | |
dc.citation.volume | 74 | |
dc.identifier.doi | 10.1021/np200241c | |
dc.identifier.pmid | 21707046 | |
dc.identifier.scopus | 2-s2.0-79960728011 | |
dc.identifier.wos | 000293036100009 | |
dc.type.version | publishedVersion |