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Efficiency and Biocompatibility of Antimicrobial Textile Material of Broad Spectrum Activity

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2011
Authors
Simović, Ljiljana
Škundrić, Petar
Kostić, Mirjana
Tasić, Goran
Kojić, Zvezdana Z.
Milaković, Branko D.
Medović, Adela
article (publishedVersion)
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Abstract
the antimicrobial textile material. The material is in the form of plaster wound dressing which is consisting of a nonwoven textile base containing polypropylene (PP)/viscose, a polymer carrier, and an antimicrobial active substance. The polymer carrier is the polysaccharide D-glucosamine (chitosan), and the active antimicrobial substance is antibiotic gentamicin sulfate. The amount of gentamicin sulfate immobilized into the polymer matrix of the polymer carrier was 0.15-0.20 mg/cm(2) or 2.0-2.5% of the mass of the nonwoven textile material. The antimicrobial textile material has been studied in vitro and in vivo conditions through the efficiency of the antimicrobial effects on different kinds of pathogenic microorganisms, as well as the biocompatibility in preclinical research. The results of these experiments indicate that all bioactive textile materials were biocidal in vitro for all pathogenic test organisms. Good biocompatibility, the existence of the correlation between the in vi...tro and in vivo results, concerning efficiency, qualifies these antimicrobial biornaterials for clinical use.

Keywords:
drug delivery system / biocompatibility / biological applications of polymers / polysaccharides
Source:
Journal of Applied Polymer Science, 2011, 120, 3, 1459-1467
Publisher:
  • Wiley, Hoboken
Funding / projects:
  • Ministry of Science of the Republic SerbiaMinistry of Science, Serbia

DOI: 10.1002/app.33235

ISSN: 0021-8995

WoS: 000288142700028

Scopus: 2-s2.0-79551690983
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URI
http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1948
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  • Radovi istraživača / Researchers’ publications (TMF)
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Tehnološko-metalurški fakultet

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