As the very first electrochemical investigation of oxaprozin, nonsteroidal anti-inflammatory drug, using cyclic voltammetry on gold electrode in 0.05 mol dm(-3) NaHCO3, the synthesized drug, its analytical standard and its content in Duraprox (R) tablets were characterized with one oxidation reaction and the three reduction reactions. All they exhibited the linear concentration dependency of anodic currents at 0.83V for the analytical standard and 0.85V for Duraprox (R) tablets in the range of concentrations 8.44 - 32.78x10(-6) mol dm(-3). The strong adsorption of bovine serum albumin (BSA) on gold electrode in 0.1 mol dm(-3) phosphate buffer solution (pH 7.4) is shown and concentration dependency of anodic currents of oxaprozin standard on BSA/Au is studied. Following the Langmuir adsorption thermodynamic equation, the binding constants of oxaprozin on BSA/Au electrode was calculated with the results 1.23x10(5) dm(3) mol(-1).
TY - JOUR
AU - Božić, Bojan
AU - Avramov-Ivić, Milka
AU - Trišović, Nemanja
AU - Petrović, Slobodan
AU - Ušćumlić, Gordana
PY - 2012
UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1998
AB - As the very first electrochemical investigation of oxaprozin, nonsteroidal anti-inflammatory drug, using cyclic voltammetry on gold electrode in 0.05 mol dm(-3) NaHCO3, the synthesized drug, its analytical standard and its content in Duraprox (R) tablets were characterized with one oxidation reaction and the three reduction reactions. All they exhibited the linear concentration dependency of anodic currents at 0.83V for the analytical standard and 0.85V for Duraprox (R) tablets in the range of concentrations 8.44 - 32.78x10(-6) mol dm(-3). The strong adsorption of bovine serum albumin (BSA) on gold electrode in 0.1 mol dm(-3) phosphate buffer solution (pH 7.4) is shown and concentration dependency of anodic currents of oxaprozin standard on BSA/Au is studied. Following the Langmuir adsorption thermodynamic equation, the binding constants of oxaprozin on BSA/Au electrode was calculated with the results 1.23x10(5) dm(3) mol(-1).
PB - Electrochemical Science Group, Beograd
T2 - International Journal of Electrochemical Science
T1 - Electrochemical Characterization of Oxaprozin on Bare Gold Electrode and Electrode Modified with Bovine Serum Albumin
EP - 11616
IS - 11
SP - 11609
VL - 7
UR - https://hdl.handle.net/21.15107/rcub_technorep_1998
ER -
@article{
author = "Božić, Bojan and Avramov-Ivić, Milka and Trišović, Nemanja and Petrović, Slobodan and Ušćumlić, Gordana",
year = "2012",
abstract = "As the very first electrochemical investigation of oxaprozin, nonsteroidal anti-inflammatory drug, using cyclic voltammetry on gold electrode in 0.05 mol dm(-3) NaHCO3, the synthesized drug, its analytical standard and its content in Duraprox (R) tablets were characterized with one oxidation reaction and the three reduction reactions. All they exhibited the linear concentration dependency of anodic currents at 0.83V for the analytical standard and 0.85V for Duraprox (R) tablets in the range of concentrations 8.44 - 32.78x10(-6) mol dm(-3). The strong adsorption of bovine serum albumin (BSA) on gold electrode in 0.1 mol dm(-3) phosphate buffer solution (pH 7.4) is shown and concentration dependency of anodic currents of oxaprozin standard on BSA/Au is studied. Following the Langmuir adsorption thermodynamic equation, the binding constants of oxaprozin on BSA/Au electrode was calculated with the results 1.23x10(5) dm(3) mol(-1).",
publisher = "Electrochemical Science Group, Beograd",
journal = "International Journal of Electrochemical Science",
title = "Electrochemical Characterization of Oxaprozin on Bare Gold Electrode and Electrode Modified with Bovine Serum Albumin",
pages = "11616-11609",
number = "11",
volume = "7",
url = "https://hdl.handle.net/21.15107/rcub_technorep_1998"
}
Božić, B., Avramov-Ivić, M., Trišović, N., Petrović, S.,& Ušćumlić, G.. (2012). Electrochemical Characterization of Oxaprozin on Bare Gold Electrode and Electrode Modified with Bovine Serum Albumin. in International Journal of Electrochemical Science
Electrochemical Science Group, Beograd., 7(11), 11609-11616.
https://hdl.handle.net/21.15107/rcub_technorep_1998
Božić B, Avramov-Ivić M, Trišović N, Petrović S, Ušćumlić G. Electrochemical Characterization of Oxaprozin on Bare Gold Electrode and Electrode Modified with Bovine Serum Albumin. in International Journal of Electrochemical Science. 2012;7(11):11609-11616.
https://hdl.handle.net/21.15107/rcub_technorep_1998 .
Božić, Bojan, Avramov-Ivić, Milka, Trišović, Nemanja, Petrović, Slobodan, Ušćumlić, Gordana, "Electrochemical Characterization of Oxaprozin on Bare Gold Electrode and Electrode Modified with Bovine Serum Albumin" in International Journal of Electrochemical Science, 7, no. 11 (2012):11609-11616,
https://hdl.handle.net/21.15107/rcub_technorep_1998 .
