Electrochemical Characterization of Oxaprozin on Bare Gold Electrode and Electrode Modified with Bovine Serum Albumin
Abstract
As the very first electrochemical investigation of oxaprozin, nonsteroidal anti-inflammatory drug, using cyclic voltammetry on gold electrode in 0.05 mol dm(-3) NaHCO3, the synthesized drug, its analytical standard and its content in Duraprox (R) tablets were characterized with one oxidation reaction and the three reduction reactions. All they exhibited the linear concentration dependency of anodic currents at 0.83V for the analytical standard and 0.85V for Duraprox (R) tablets in the range of concentrations 8.44 - 32.78x10(-6) mol dm(-3). The strong adsorption of bovine serum albumin (BSA) on gold electrode in 0.1 mol dm(-3) phosphate buffer solution (pH 7.4) is shown and concentration dependency of anodic currents of oxaprozin standard on BSA/Au is studied. Following the Langmuir adsorption thermodynamic equation, the binding constants of oxaprozin on BSA/Au electrode was calculated with the results 1.23x10(5) dm(3) mol(-1).
Keywords:
oxaprozin / gold electrode / bovine serum albumin / concentration dependency / Langmuir adsorptionSource:
International Journal of Electrochemical Science, 2012, 7, 11, 11609-11616Publisher:
- Electrochemical Science Group, Beograd
Funding / projects:
- Study of the Synthesis, Structure and Activity of Natural and Synthetic Organic Compounds (RS-172013)
Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Božić, Bojan AU - Avramov-Ivić, Milka AU - Trišović, Nemanja AU - Petrović, Slobodan AU - Ušćumlić, Gordana PY - 2012 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1998 AB - As the very first electrochemical investigation of oxaprozin, nonsteroidal anti-inflammatory drug, using cyclic voltammetry on gold electrode in 0.05 mol dm(-3) NaHCO3, the synthesized drug, its analytical standard and its content in Duraprox (R) tablets were characterized with one oxidation reaction and the three reduction reactions. All they exhibited the linear concentration dependency of anodic currents at 0.83V for the analytical standard and 0.85V for Duraprox (R) tablets in the range of concentrations 8.44 - 32.78x10(-6) mol dm(-3). The strong adsorption of bovine serum albumin (BSA) on gold electrode in 0.1 mol dm(-3) phosphate buffer solution (pH 7.4) is shown and concentration dependency of anodic currents of oxaprozin standard on BSA/Au is studied. Following the Langmuir adsorption thermodynamic equation, the binding constants of oxaprozin on BSA/Au electrode was calculated with the results 1.23x10(5) dm(3) mol(-1). PB - Electrochemical Science Group, Beograd T2 - International Journal of Electrochemical Science T1 - Electrochemical Characterization of Oxaprozin on Bare Gold Electrode and Electrode Modified with Bovine Serum Albumin EP - 11616 IS - 11 SP - 11609 VL - 7 UR - https://hdl.handle.net/21.15107/rcub_technorep_1998 ER -
@article{ author = "Božić, Bojan and Avramov-Ivić, Milka and Trišović, Nemanja and Petrović, Slobodan and Ušćumlić, Gordana", year = "2012", abstract = "As the very first electrochemical investigation of oxaprozin, nonsteroidal anti-inflammatory drug, using cyclic voltammetry on gold electrode in 0.05 mol dm(-3) NaHCO3, the synthesized drug, its analytical standard and its content in Duraprox (R) tablets were characterized with one oxidation reaction and the three reduction reactions. All they exhibited the linear concentration dependency of anodic currents at 0.83V for the analytical standard and 0.85V for Duraprox (R) tablets in the range of concentrations 8.44 - 32.78x10(-6) mol dm(-3). The strong adsorption of bovine serum albumin (BSA) on gold electrode in 0.1 mol dm(-3) phosphate buffer solution (pH 7.4) is shown and concentration dependency of anodic currents of oxaprozin standard on BSA/Au is studied. Following the Langmuir adsorption thermodynamic equation, the binding constants of oxaprozin on BSA/Au electrode was calculated with the results 1.23x10(5) dm(3) mol(-1).", publisher = "Electrochemical Science Group, Beograd", journal = "International Journal of Electrochemical Science", title = "Electrochemical Characterization of Oxaprozin on Bare Gold Electrode and Electrode Modified with Bovine Serum Albumin", pages = "11616-11609", number = "11", volume = "7", url = "https://hdl.handle.net/21.15107/rcub_technorep_1998" }
Božić, B., Avramov-Ivić, M., Trišović, N., Petrović, S.,& Ušćumlić, G.. (2012). Electrochemical Characterization of Oxaprozin on Bare Gold Electrode and Electrode Modified with Bovine Serum Albumin. in International Journal of Electrochemical Science Electrochemical Science Group, Beograd., 7(11), 11609-11616. https://hdl.handle.net/21.15107/rcub_technorep_1998
Božić B, Avramov-Ivić M, Trišović N, Petrović S, Ušćumlić G. Electrochemical Characterization of Oxaprozin on Bare Gold Electrode and Electrode Modified with Bovine Serum Albumin. in International Journal of Electrochemical Science. 2012;7(11):11609-11616. https://hdl.handle.net/21.15107/rcub_technorep_1998 .
Božić, Bojan, Avramov-Ivić, Milka, Trišović, Nemanja, Petrović, Slobodan, Ušćumlić, Gordana, "Electrochemical Characterization of Oxaprozin on Bare Gold Electrode and Electrode Modified with Bovine Serum Albumin" in International Journal of Electrochemical Science, 7, no. 11 (2012):11609-11616, https://hdl.handle.net/21.15107/rcub_technorep_1998 .