Influence of monomer and crosslinker molar ratio on the swelling behaviour of thermosensitive hydrogels
Uticaj molarnog odnosa monomera i umreživača na karakteristike bubrenja termoosetljivih hidrogelova
Authors
Ilić-Stojanović, Snežana
Nikolić, Ljubiša B.
Nikolić, Vesna
Stanković, Mihajlo
Stamenković, Jakov
Mladenović-Ranisavljević, Ivana

Petrović, Slobodan
Article (Published version)
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Show full item recordAbstract
The synthesis of the poly(N-isopropylacrylamide-co-2-hydroxypropyl-methacrylate) hydrogel along with the analysis of the residual monomers content and influence of monomer and crosslinker molar ratios on the swelling behaviour was investigated. Synthesis of thermosensitive hydrogel based on N-isopropylacrylamide was carried out with the molar ratios of 5, 10, 15 and 20 mol% of monomer 2-hydroxypropyl-methacrylate, in the presence of ethylene glycol dimethacrylate as a crosslinker (1, 1.5, 2 and 3 mol%) and 2,2'-azobis(2-methylpropionitrile) as an initiator in acetone. The quantities of residual monomers in the synthesized copolymers were determined by HPLC method, ranging from 0.19 to 0.49% for N-isopropylacrylamide and from 0.13 to 0.63% for 2- -hydroxypropyl-methacrylate, counting the amount of xerogel. The hydrogels swelling ratio depending on time at 20 and 40°C was examined. It was found that the hydrogel with 5 mol% 2-hydroxypropyl-methacrylate and 1 mol% ethylene glycol dimethac...rylate had the highest degree of swelling (( = 29.59) at 20°C, and that the hydrogel with 20 mol% 2-hydroxypropyl-methacrylate and 3 mol% ethylene glycol dimethacrylate had the lowest swelling degree ((=2.17) at 40°C.
Predmet ovog rada je sinteza kopolimernog hidrogela poli(N-izopropilakrilamid-ko-2-hidroksipropilmetakrilata), analiza sadržaja rezidualnih monomera i ispitivanje uticaja molskog odnosa monomera i umreživača na karakteristike bubrenja. Sinteza termoosetljivog hidrogela na bazi N-izopropilakrilamida izvršena je sa molarnim udelom 5, 10, 15 i 20 mol% monomera 2-hidroksipropilmetakrilata, u prisustvu umreživača etilenglikoldimetakrilata (u koncentraciji: 1, 1,5 , 2 i 3 mol%) i inicijatora 2,2'-azobis(2-metilpropionitrila) u acetonu. Sadržaj zaostalih monomera u sintetizovanim kopolimerima analiziran je pomoću HPLC metode. Vrednosti se nalaze u granicama od 0,19 do 0,49% za N-izopropilakrilamid i od 0,13 do 0,63% za 2-hidroksipropilmetakrilat računajući na količinu kserogela. Ispitan je stepen bubrenja dobijenih hidrogelova u zavisnosti od temperature. Najveći stepen bubrenja (( = 29,59) pri konstantnoj temperaturi od 20°C dostigao je uzorak hidrogela sa 5 mol% 2-hidroksipropilmetakrilata ...i 1 mol% umreživača EGDM-a, a najmanji (( = 2.17) pri temperaturi od 40°C dostigao je uzorak hidrogela sa 20 mol% 2-hidroksipropilmetakrilata i 3 mol% umreživača EGDM-a. PR Projekat Ministarstva nauke Republike Srbije, br. TR 34012.
Keywords:
thermosensitive hydrogel / residual monomers / swelling / N-isopropylacrylamide / 2-hydroxypropyl-methacrylate / termoosetljivi hidrogelovi / bubrenje / rezidualni monomeri / N-izopropilakrilamid / 2-hidroksipropilmetakrilatSource:
Chemical Industry & Chemical Engineering Quarterly, 2012, 18, 1, 1-9Publisher:
- Association of the Chemical Engineers of Serbia
Funding / projects:
DOI: 10.2298/CICEQ110711040I
ISSN: 1451-9372
WoS: 000305925200001
Scopus: 2-s2.0-84859353741
Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Ilić-Stojanović, Snežana AU - Nikolić, Ljubiša B. AU - Nikolić, Vesna AU - Stanković, Mihajlo AU - Stamenković, Jakov AU - Mladenović-Ranisavljević, Ivana AU - Petrović, Slobodan PY - 2012 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2069 AB - The synthesis of the poly(N-isopropylacrylamide-co-2-hydroxypropyl-methacrylate) hydrogel along with the analysis of the residual monomers content and influence of monomer and crosslinker molar ratios on the swelling behaviour was investigated. Synthesis of thermosensitive hydrogel based on N-isopropylacrylamide was carried out with the molar ratios of 5, 10, 15 and 20 mol% of monomer 2-hydroxypropyl-methacrylate, in the presence of ethylene glycol dimethacrylate as a crosslinker (1, 1.5, 2 and 3 mol%) and 2,2'-azobis(2-methylpropionitrile) as an initiator in acetone. The quantities of residual monomers in the synthesized copolymers were determined by HPLC method, ranging from 0.19 to 0.49% for N-isopropylacrylamide and from 0.13 to 0.63% for 2- -hydroxypropyl-methacrylate, counting the amount of xerogel. The hydrogels swelling ratio depending on time at 20 and 40°C was examined. It was found that the hydrogel with 5 mol% 2-hydroxypropyl-methacrylate and 1 mol% ethylene glycol dimethacrylate had the highest degree of swelling (( = 29.59) at 20°C, and that the hydrogel with 20 mol% 2-hydroxypropyl-methacrylate and 3 mol% ethylene glycol dimethacrylate had the lowest swelling degree ((=2.17) at 40°C. AB - Predmet ovog rada je sinteza kopolimernog hidrogela poli(N-izopropilakrilamid-ko-2-hidroksipropilmetakrilata), analiza sadržaja rezidualnih monomera i ispitivanje uticaja molskog odnosa monomera i umreživača na karakteristike bubrenja. Sinteza termoosetljivog hidrogela na bazi N-izopropilakrilamida izvršena je sa molarnim udelom 5, 10, 15 i 20 mol% monomera 2-hidroksipropilmetakrilata, u prisustvu umreživača etilenglikoldimetakrilata (u koncentraciji: 1, 1,5 , 2 i 3 mol%) i inicijatora 2,2'-azobis(2-metilpropionitrila) u acetonu. Sadržaj zaostalih monomera u sintetizovanim kopolimerima analiziran je pomoću HPLC metode. Vrednosti se nalaze u granicama od 0,19 do 0,49% za N-izopropilakrilamid i od 0,13 do 0,63% za 2-hidroksipropilmetakrilat računajući na količinu kserogela. Ispitan je stepen bubrenja dobijenih hidrogelova u zavisnosti od temperature. Najveći stepen bubrenja (( = 29,59) pri konstantnoj temperaturi od 20°C dostigao je uzorak hidrogela sa 5 mol% 2-hidroksipropilmetakrilata i 1 mol% umreživača EGDM-a, a najmanji (( = 2.17) pri temperaturi od 40°C dostigao je uzorak hidrogela sa 20 mol% 2-hidroksipropilmetakrilata i 3 mol% umreživača EGDM-a. PR Projekat Ministarstva nauke Republike Srbije, br. TR 34012. PB - Association of the Chemical Engineers of Serbia T2 - Chemical Industry & Chemical Engineering Quarterly T1 - Influence of monomer and crosslinker molar ratio on the swelling behaviour of thermosensitive hydrogels T1 - Uticaj molarnog odnosa monomera i umreživača na karakteristike bubrenja termoosetljivih hidrogelova EP - 9 IS - 1 SP - 1 VL - 18 DO - 10.2298/CICEQ110711040I ER -
@article{ author = "Ilić-Stojanović, Snežana and Nikolić, Ljubiša B. and Nikolić, Vesna and Stanković, Mihajlo and Stamenković, Jakov and Mladenović-Ranisavljević, Ivana and Petrović, Slobodan", year = "2012", abstract = "The synthesis of the poly(N-isopropylacrylamide-co-2-hydroxypropyl-methacrylate) hydrogel along with the analysis of the residual monomers content and influence of monomer and crosslinker molar ratios on the swelling behaviour was investigated. Synthesis of thermosensitive hydrogel based on N-isopropylacrylamide was carried out with the molar ratios of 5, 10, 15 and 20 mol% of monomer 2-hydroxypropyl-methacrylate, in the presence of ethylene glycol dimethacrylate as a crosslinker (1, 1.5, 2 and 3 mol%) and 2,2'-azobis(2-methylpropionitrile) as an initiator in acetone. The quantities of residual monomers in the synthesized copolymers were determined by HPLC method, ranging from 0.19 to 0.49% for N-isopropylacrylamide and from 0.13 to 0.63% for 2- -hydroxypropyl-methacrylate, counting the amount of xerogel. The hydrogels swelling ratio depending on time at 20 and 40°C was examined. It was found that the hydrogel with 5 mol% 2-hydroxypropyl-methacrylate and 1 mol% ethylene glycol dimethacrylate had the highest degree of swelling (( = 29.59) at 20°C, and that the hydrogel with 20 mol% 2-hydroxypropyl-methacrylate and 3 mol% ethylene glycol dimethacrylate had the lowest swelling degree ((=2.17) at 40°C., Predmet ovog rada je sinteza kopolimernog hidrogela poli(N-izopropilakrilamid-ko-2-hidroksipropilmetakrilata), analiza sadržaja rezidualnih monomera i ispitivanje uticaja molskog odnosa monomera i umreživača na karakteristike bubrenja. Sinteza termoosetljivog hidrogela na bazi N-izopropilakrilamida izvršena je sa molarnim udelom 5, 10, 15 i 20 mol% monomera 2-hidroksipropilmetakrilata, u prisustvu umreživača etilenglikoldimetakrilata (u koncentraciji: 1, 1,5 , 2 i 3 mol%) i inicijatora 2,2'-azobis(2-metilpropionitrila) u acetonu. Sadržaj zaostalih monomera u sintetizovanim kopolimerima analiziran je pomoću HPLC metode. Vrednosti se nalaze u granicama od 0,19 do 0,49% za N-izopropilakrilamid i od 0,13 do 0,63% za 2-hidroksipropilmetakrilat računajući na količinu kserogela. Ispitan je stepen bubrenja dobijenih hidrogelova u zavisnosti od temperature. Najveći stepen bubrenja (( = 29,59) pri konstantnoj temperaturi od 20°C dostigao je uzorak hidrogela sa 5 mol% 2-hidroksipropilmetakrilata i 1 mol% umreživača EGDM-a, a najmanji (( = 2.17) pri temperaturi od 40°C dostigao je uzorak hidrogela sa 20 mol% 2-hidroksipropilmetakrilata i 3 mol% umreživača EGDM-a. PR Projekat Ministarstva nauke Republike Srbije, br. TR 34012.", publisher = "Association of the Chemical Engineers of Serbia", journal = "Chemical Industry & Chemical Engineering Quarterly", title = "Influence of monomer and crosslinker molar ratio on the swelling behaviour of thermosensitive hydrogels, Uticaj molarnog odnosa monomera i umreživača na karakteristike bubrenja termoosetljivih hidrogelova", pages = "9-1", number = "1", volume = "18", doi = "10.2298/CICEQ110711040I" }
Ilić-Stojanović, S., Nikolić, L. B., Nikolić, V., Stanković, M., Stamenković, J., Mladenović-Ranisavljević, I.,& Petrović, S.. (2012). Influence of monomer and crosslinker molar ratio on the swelling behaviour of thermosensitive hydrogels. in Chemical Industry & Chemical Engineering Quarterly Association of the Chemical Engineers of Serbia., 18(1), 1-9. https://doi.org/10.2298/CICEQ110711040I
Ilić-Stojanović S, Nikolić LB, Nikolić V, Stanković M, Stamenković J, Mladenović-Ranisavljević I, Petrović S. Influence of monomer and crosslinker molar ratio on the swelling behaviour of thermosensitive hydrogels. in Chemical Industry & Chemical Engineering Quarterly. 2012;18(1):1-9. doi:10.2298/CICEQ110711040I .
Ilić-Stojanović, Snežana, Nikolić, Ljubiša B., Nikolić, Vesna, Stanković, Mihajlo, Stamenković, Jakov, Mladenović-Ranisavljević, Ivana, Petrović, Slobodan, "Influence of monomer and crosslinker molar ratio on the swelling behaviour of thermosensitive hydrogels" in Chemical Industry & Chemical Engineering Quarterly, 18, no. 1 (2012):1-9, https://doi.org/10.2298/CICEQ110711040I . .