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Diffusion of drugs in hydrogels based on (meth)acrylates, poly(alkylene glycol) (meth)acrylates and itaconic acid

Difuzija lekova u hidrogelovima na bazi (met)akrilata, poli(alkilenglikol)-(met)akrilata i itakonske kiseline

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2012
0367-598X1206823B.pdf (313.1Kb)
Authors
Babić, Marija
Jovašević, Jovana S.
Filipović, Jovanka M.
Tomić, Simonida
Article (Published version)
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Abstract
The aim of this paper is to propose equations for the diffusion of drugs for investigated drug/hydrogel systems using the parameters affecting the transport of drug through poly- (2-hydroxyethylmethacrylate/itaconic acid) (P(HEMA/IA)), poly(2-hydroxyethylacrylate/ita- conic acid) (P(HEA/IA)), and poly(2-hydroxyethylmethacrylate/poly(alkyleneglycol) (meth)- acrylates) (P(HEMA/BIS)) copolymeric hydrogels. Different monomer types, as well as the variable content of some components in hydrogel composition (the amount of ionizable comonomer (IA) and different type of nonionic poly(alkyleneglycol) (meth)acrylates), ultimately defined the pore size available for drug diffusion. The hydrogels synthesized ranged from nonporous to microporous, based on the classification in accordance to the pore size, and could be classified as hydrogels that contain ionic groups and hydrogels without ionic groups. The drugs selected for this study are bronchodilators-theophylline (TPH), fenethylline hydrochlor...ide (FE), and antibiotic cephalexin (CEX). Results of in vitro drug release tests defined the release systems based on the drug type, as well as the type of hydrogel used. The diffusion coefficient of drugs and the restriction coefficient, λ, defined as the ratio of solute to 'pore' radius (rs/rζ) that describes the ease of drug release from the gels, were used as factors that govern the release process.

Cilj ove studije je da se predlože difuzione jednačine za ispitivane sisteme lek/hidrogel. Korišćeni su hidrogelovi poli(2-hidroksietilmetakrilat/itakonska kiselina) (P(HEMA/IK)), poli(2-hidroksietilakrilat/itakonska kiselina) (P(HEA/IK)) i poli-(2-hidroksietilmetakrilat/poli(alkilenglikol)-(met)akrilati) (P(HEMA/BIS)). Komponenta koja se menja u sastavu hidrogela HEMA, HEA, kao i udeo komponente sa promenljivim sadržajem (udeo jonizujućeg komonomera (IK) i tip BIS komponente) definiše veličinu pora koja je dostupna za difuziju leka. U ovoj studiji su korišćeni lekovi bronhodilatori teofilin (TPH) i fenetilin-hidrohlorid (FE), i antibiotik cefaleksin (CEX). Ovi gelovi su klasifikovani u režimu poroznosti kao neporozni i mikroporozni, sa veličinom pora u opsegu 0,18-24,9 nm. Kontrolisano otpuštanje lekova je izvedeno u in vitro uslovima u puferu pH 7,40 i na 37 °C, da bi se odredili difuzioni koeficijenti leka u hidrogelovima. Na osnovu toga su predložene jednačine difuzije leka kroz hi...drogel za svaki sistem lek/hidrogel. Rezultati dobijeni fitovanjem eksperimentalnih podataka su pokazali da difuzija leka zavisi od hemijske strukture i morfologije hidrogela i parametra λ, koji predstavlja odnos prečnika leka i veličine pora. Eksponencijalna zavisnost koeficijenta restrikcije od normalizovanog koeficijenta difuzije je dobijena za sisteme TPH/P(HEMA/IA), FE/P(HEMA/ /IA), CEX/P(HEMA/BIS) i CEX/P(HEA/IA).Utvrđeno je da veliki uticaj na difuziju leka imaju interakcije koje se odigravaju između funkcionalnih grupa leka i polimerne mreže.

Keywords:
hydrogels / 2-hydroxyethyl methacrylate / 2-hydroxyethyl acrylate / poly(alkylene glycol) (meth)acrylates / itaconic acid / controlled drug release / controlled drug release parameters / diffusion equations / hidrogelovi / 2-hidroksietil-metakrilat / 2-hidroksietilakrilat / poli-(alkilenglikol)-(met)akrilati / itakonska kiselina / kontrolisano otpuštanje leka / parametri kontrolisanog otpuštanja leka / jednačine difuzije
Source:
Hemijska industrija, 2012, 66, 6, 823-829
Publisher:
  • Association of Chemical Engineers of Serbia
Funding / projects:
  • Chemical and structural designing of nanomaterials for application in medicine and tissue engineering (RS-172026)
  • Synthesis and characterization of novel functional polymers and polymeric nanocomposites (RS-172062)

DOI: 10.2298/HEMIND120406073B

ISSN: 0367-598X

WoS: 000315368700004

Scopus: 2-s2.0-84871701257
[ Google Scholar ]
6
6
URI
http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2093
Collections
  • Radovi istraživača / Researchers’ publications (TMF)
  • Radovi istraživača (Inovacioni centar) / Researchers’ publications (Innovation Centre)
Institution/Community
Tehnološko-metalurški fakultet
TY  - JOUR
AU  - Babić, Marija
AU  - Jovašević, Jovana S.
AU  - Filipović, Jovanka M.
AU  - Tomić, Simonida
PY  - 2012
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2093
AB  - The aim of this paper is to propose equations for the diffusion of drugs for investigated drug/hydrogel systems using the parameters affecting the transport of drug through poly- (2-hydroxyethylmethacrylate/itaconic acid) (P(HEMA/IA)), poly(2-hydroxyethylacrylate/ita- conic acid) (P(HEA/IA)), and poly(2-hydroxyethylmethacrylate/poly(alkyleneglycol) (meth)- acrylates) (P(HEMA/BIS)) copolymeric hydrogels. Different monomer types, as well as the variable content of some components in hydrogel composition (the amount of ionizable comonomer (IA) and different type of nonionic poly(alkyleneglycol) (meth)acrylates), ultimately defined the pore size available for drug diffusion. The hydrogels synthesized ranged from nonporous to microporous, based on the classification in accordance to the pore size, and could be classified as hydrogels that contain ionic groups and hydrogels without ionic groups. The drugs selected for this study are bronchodilators-theophylline (TPH), fenethylline hydrochloride (FE), and antibiotic cephalexin (CEX). Results of in vitro drug release tests defined the release systems based on the drug type, as well as the type of hydrogel used. The diffusion coefficient of drugs and the restriction coefficient, λ, defined as the ratio of solute to 'pore' radius (rs/rζ) that describes the ease of drug release from the gels, were used as factors that govern the release process.
AB  - Cilj ove studije je da se predlože difuzione jednačine za ispitivane sisteme lek/hidrogel. Korišćeni su hidrogelovi poli(2-hidroksietilmetakrilat/itakonska kiselina) (P(HEMA/IK)), poli(2-hidroksietilakrilat/itakonska kiselina) (P(HEA/IK)) i poli-(2-hidroksietilmetakrilat/poli(alkilenglikol)-(met)akrilati) (P(HEMA/BIS)). Komponenta koja se menja u sastavu hidrogela HEMA, HEA, kao i udeo komponente sa promenljivim sadržajem (udeo jonizujućeg komonomera (IK) i tip BIS komponente) definiše veličinu pora koja je dostupna za difuziju leka. U ovoj studiji su korišćeni lekovi bronhodilatori teofilin (TPH) i fenetilin-hidrohlorid (FE), i antibiotik cefaleksin (CEX). Ovi gelovi su klasifikovani u režimu poroznosti kao neporozni i mikroporozni, sa veličinom pora u opsegu 0,18-24,9 nm. Kontrolisano otpuštanje lekova je izvedeno u in vitro uslovima u puferu pH 7,40 i na 37 °C, da bi se odredili difuzioni koeficijenti leka u hidrogelovima. Na osnovu toga su predložene jednačine difuzije leka kroz hidrogel za svaki sistem lek/hidrogel. Rezultati dobijeni fitovanjem eksperimentalnih podataka su pokazali da difuzija leka zavisi od hemijske strukture i morfologije hidrogela i parametra λ, koji predstavlja odnos prečnika leka i veličine pora. Eksponencijalna zavisnost koeficijenta restrikcije od normalizovanog koeficijenta difuzije je dobijena za sisteme TPH/P(HEMA/IA), FE/P(HEMA/ /IA), CEX/P(HEMA/BIS) i CEX/P(HEA/IA).Utvrđeno je da veliki uticaj na difuziju leka imaju interakcije koje se odigravaju između funkcionalnih grupa leka i polimerne mreže.
PB  - Association of Chemical Engineers of Serbia
T2  - Hemijska industrija
T1  - Diffusion of drugs in hydrogels based on (meth)acrylates, poly(alkylene glycol) (meth)acrylates and itaconic acid
T1  - Difuzija lekova u hidrogelovima na bazi (met)akrilata, poli(alkilenglikol)-(met)akrilata i itakonske kiseline
EP  - 829
IS  - 6
SP  - 823
VL  - 66
DO  - 10.2298/HEMIND120406073B
ER  - 
@article{
author = "Babić, Marija and Jovašević, Jovana S. and Filipović, Jovanka M. and Tomić, Simonida",
year = "2012",
abstract = "The aim of this paper is to propose equations for the diffusion of drugs for investigated drug/hydrogel systems using the parameters affecting the transport of drug through poly- (2-hydroxyethylmethacrylate/itaconic acid) (P(HEMA/IA)), poly(2-hydroxyethylacrylate/ita- conic acid) (P(HEA/IA)), and poly(2-hydroxyethylmethacrylate/poly(alkyleneglycol) (meth)- acrylates) (P(HEMA/BIS)) copolymeric hydrogels. Different monomer types, as well as the variable content of some components in hydrogel composition (the amount of ionizable comonomer (IA) and different type of nonionic poly(alkyleneglycol) (meth)acrylates), ultimately defined the pore size available for drug diffusion. The hydrogels synthesized ranged from nonporous to microporous, based on the classification in accordance to the pore size, and could be classified as hydrogels that contain ionic groups and hydrogels without ionic groups. The drugs selected for this study are bronchodilators-theophylline (TPH), fenethylline hydrochloride (FE), and antibiotic cephalexin (CEX). Results of in vitro drug release tests defined the release systems based on the drug type, as well as the type of hydrogel used. The diffusion coefficient of drugs and the restriction coefficient, λ, defined as the ratio of solute to 'pore' radius (rs/rζ) that describes the ease of drug release from the gels, were used as factors that govern the release process., Cilj ove studije je da se predlože difuzione jednačine za ispitivane sisteme lek/hidrogel. Korišćeni su hidrogelovi poli(2-hidroksietilmetakrilat/itakonska kiselina) (P(HEMA/IK)), poli(2-hidroksietilakrilat/itakonska kiselina) (P(HEA/IK)) i poli-(2-hidroksietilmetakrilat/poli(alkilenglikol)-(met)akrilati) (P(HEMA/BIS)). Komponenta koja se menja u sastavu hidrogela HEMA, HEA, kao i udeo komponente sa promenljivim sadržajem (udeo jonizujućeg komonomera (IK) i tip BIS komponente) definiše veličinu pora koja je dostupna za difuziju leka. U ovoj studiji su korišćeni lekovi bronhodilatori teofilin (TPH) i fenetilin-hidrohlorid (FE), i antibiotik cefaleksin (CEX). Ovi gelovi su klasifikovani u režimu poroznosti kao neporozni i mikroporozni, sa veličinom pora u opsegu 0,18-24,9 nm. Kontrolisano otpuštanje lekova je izvedeno u in vitro uslovima u puferu pH 7,40 i na 37 °C, da bi se odredili difuzioni koeficijenti leka u hidrogelovima. Na osnovu toga su predložene jednačine difuzije leka kroz hidrogel za svaki sistem lek/hidrogel. Rezultati dobijeni fitovanjem eksperimentalnih podataka su pokazali da difuzija leka zavisi od hemijske strukture i morfologije hidrogela i parametra λ, koji predstavlja odnos prečnika leka i veličine pora. Eksponencijalna zavisnost koeficijenta restrikcije od normalizovanog koeficijenta difuzije je dobijena za sisteme TPH/P(HEMA/IA), FE/P(HEMA/ /IA), CEX/P(HEMA/BIS) i CEX/P(HEA/IA).Utvrđeno je da veliki uticaj na difuziju leka imaju interakcije koje se odigravaju između funkcionalnih grupa leka i polimerne mreže.",
publisher = "Association of Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "Diffusion of drugs in hydrogels based on (meth)acrylates, poly(alkylene glycol) (meth)acrylates and itaconic acid, Difuzija lekova u hidrogelovima na bazi (met)akrilata, poli(alkilenglikol)-(met)akrilata i itakonske kiseline",
pages = "829-823",
number = "6",
volume = "66",
doi = "10.2298/HEMIND120406073B"
}
Babić, M., Jovašević, J. S., Filipović, J. M.,& Tomić, S.. (2012). Diffusion of drugs in hydrogels based on (meth)acrylates, poly(alkylene glycol) (meth)acrylates and itaconic acid. in Hemijska industrija
Association of Chemical Engineers of Serbia., 66(6), 823-829.
https://doi.org/10.2298/HEMIND120406073B
Babić M, Jovašević JS, Filipović JM, Tomić S. Diffusion of drugs in hydrogels based on (meth)acrylates, poly(alkylene glycol) (meth)acrylates and itaconic acid. in Hemijska industrija. 2012;66(6):823-829.
doi:10.2298/HEMIND120406073B .
Babić, Marija, Jovašević, Jovana S., Filipović, Jovanka M., Tomić, Simonida, "Diffusion of drugs in hydrogels based on (meth)acrylates, poly(alkylene glycol) (meth)acrylates and itaconic acid" in Hemijska industrija, 66, no. 6 (2012):823-829,
https://doi.org/10.2298/HEMIND120406073B . .

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