Surfactant-modified clinoptilolite as a salicylate carrier, salicylate kinetic release and its antibacterial activity

Abstract

The cationic surfactant benzalkonium chloride (BC) was used for modification of the natural clinoptilolite surface in order to prepare a suitable carrier for the salicylate anion. The salicylate-containing clinoptilolite composite was prepared by adsorption from an aqueous aspirin solution. The composite releases salicylate in two stages: about 50% of the adsorbed salicylate is delivered in the first 15 min and an additional 30% is released slowly within the next 5 h. The Korsmeyer-Peppas model best describes the release profile. Both the BC-modified clinoptilolite and the salicylate-containing product were tested against Escherichia coli and Staphylococcus aureus. The results indicate that the salicylate-containing material may represent an alternative drug having simultaneous antibacterial and anti-inflammatory effects.