The effect of grain size on the biocompatibility, cell-materials interface, and mechanical properties of microwave-sintered bioceramics
Само за регистроване кориснике
2012
Аутори
Veljović, ĐorđeČolić, Miodrag
Kojić, Vesna
Bogdanović, Gordana
Kojić, Zvezdana
Banjac, Andrijana
Palcevskis, Eriks
Petrović, Rada
Janaćković, Đorđe
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The effect of decreasing the grain size on the biocompatibility, cellmaterial interface, and mechanical properties of microwave-sintered monophase hydroxyapatite bioceramics was investigated in this study. A nanosized stoichiometric hydroxyapatite powder was isostatically pressed at high pressure and sintered in a microwave furnace in order to obtain fine grained dense bioceramics. The samples sintered at 1200 degrees C, with a density near the theoretical one, were composed of micron-sized grains, while the grain size decreased to 130 nm on decreasing the sintering temperature to 900 degrees C. This decrease in the grain size certainly led to increases in the fracture toughness by much as 54%. An in vitro investigation of biocompatibility with L929 and human MRC-5 fibroblast cells showed noncytotoxic effects for both types of bioceramics, while the relative cell proliferation rate, cell attachment and metabolic activity of the fibroblasts were improved with decreasing of grain size. A...n initial in vivo investigation of biocompatibility by the primary cutaneous irritation test showed that both materials exhibited no irritation properties.
Кључне речи:
hydroxyapatite / microwave sintering / fracture toughness / cell proliferation / biocompatibilityИзвор:
Journal of Biomedical Materials Research Part A, 2012, 100A, 11, 3059-3070Издавач:
- Wiley, Hoboken
Финансирање / пројекти:
- Reinforcing of Nanotechnology and Functional Materials Centre (EU-FP7-245916)
DOI: 10.1002/jbm.a.34225
ISSN: 1549-3296
PubMed: 22733649
WoS: 000309063400022
Scopus: 2-s2.0-84869082156
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Veljović, Đorđe AU - Čolić, Miodrag AU - Kojić, Vesna AU - Bogdanović, Gordana AU - Kojić, Zvezdana AU - Banjac, Andrijana AU - Palcevskis, Eriks AU - Petrović, Rada AU - Janaćković, Đorđe PY - 2012 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2174 AB - The effect of decreasing the grain size on the biocompatibility, cellmaterial interface, and mechanical properties of microwave-sintered monophase hydroxyapatite bioceramics was investigated in this study. A nanosized stoichiometric hydroxyapatite powder was isostatically pressed at high pressure and sintered in a microwave furnace in order to obtain fine grained dense bioceramics. The samples sintered at 1200 degrees C, with a density near the theoretical one, were composed of micron-sized grains, while the grain size decreased to 130 nm on decreasing the sintering temperature to 900 degrees C. This decrease in the grain size certainly led to increases in the fracture toughness by much as 54%. An in vitro investigation of biocompatibility with L929 and human MRC-5 fibroblast cells showed noncytotoxic effects for both types of bioceramics, while the relative cell proliferation rate, cell attachment and metabolic activity of the fibroblasts were improved with decreasing of grain size. An initial in vivo investigation of biocompatibility by the primary cutaneous irritation test showed that both materials exhibited no irritation properties. PB - Wiley, Hoboken T2 - Journal of Biomedical Materials Research Part A T1 - The effect of grain size on the biocompatibility, cell-materials interface, and mechanical properties of microwave-sintered bioceramics EP - 3070 IS - 11 SP - 3059 VL - 100A DO - 10.1002/jbm.a.34225 ER -
@article{ author = "Veljović, Đorđe and Čolić, Miodrag and Kojić, Vesna and Bogdanović, Gordana and Kojić, Zvezdana and Banjac, Andrijana and Palcevskis, Eriks and Petrović, Rada and Janaćković, Đorđe", year = "2012", abstract = "The effect of decreasing the grain size on the biocompatibility, cellmaterial interface, and mechanical properties of microwave-sintered monophase hydroxyapatite bioceramics was investigated in this study. A nanosized stoichiometric hydroxyapatite powder was isostatically pressed at high pressure and sintered in a microwave furnace in order to obtain fine grained dense bioceramics. The samples sintered at 1200 degrees C, with a density near the theoretical one, were composed of micron-sized grains, while the grain size decreased to 130 nm on decreasing the sintering temperature to 900 degrees C. This decrease in the grain size certainly led to increases in the fracture toughness by much as 54%. An in vitro investigation of biocompatibility with L929 and human MRC-5 fibroblast cells showed noncytotoxic effects for both types of bioceramics, while the relative cell proliferation rate, cell attachment and metabolic activity of the fibroblasts were improved with decreasing of grain size. An initial in vivo investigation of biocompatibility by the primary cutaneous irritation test showed that both materials exhibited no irritation properties.", publisher = "Wiley, Hoboken", journal = "Journal of Biomedical Materials Research Part A", title = "The effect of grain size on the biocompatibility, cell-materials interface, and mechanical properties of microwave-sintered bioceramics", pages = "3070-3059", number = "11", volume = "100A", doi = "10.1002/jbm.a.34225" }
Veljović, Đ., Čolić, M., Kojić, V., Bogdanović, G., Kojić, Z., Banjac, A., Palcevskis, E., Petrović, R.,& Janaćković, Đ.. (2012). The effect of grain size on the biocompatibility, cell-materials interface, and mechanical properties of microwave-sintered bioceramics. in Journal of Biomedical Materials Research Part A Wiley, Hoboken., 100A(11), 3059-3070. https://doi.org/10.1002/jbm.a.34225
Veljović Đ, Čolić M, Kojić V, Bogdanović G, Kojić Z, Banjac A, Palcevskis E, Petrović R, Janaćković Đ. The effect of grain size on the biocompatibility, cell-materials interface, and mechanical properties of microwave-sintered bioceramics. in Journal of Biomedical Materials Research Part A. 2012;100A(11):3059-3070. doi:10.1002/jbm.a.34225 .
Veljović, Đorđe, Čolić, Miodrag, Kojić, Vesna, Bogdanović, Gordana, Kojić, Zvezdana, Banjac, Andrijana, Palcevskis, Eriks, Petrović, Rada, Janaćković, Đorđe, "The effect of grain size on the biocompatibility, cell-materials interface, and mechanical properties of microwave-sintered bioceramics" in Journal of Biomedical Materials Research Part A, 100A, no. 11 (2012):3059-3070, https://doi.org/10.1002/jbm.a.34225 . .