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dc.creatorTrišović, Nemanja
dc.creatorTimić, Tamara
dc.creatorDivljaković, Jovana
dc.creatorRogan, Jelena
dc.creatorPoleti, Dejan
dc.creatorSavić, Miroslav
dc.creatorUšćumlić, Gordana
dc.date.accessioned2021-03-10T11:54:12Z
dc.date.available2021-03-10T11:54:12Z
dc.date.issued2012
dc.identifier.issn0026-9247
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/2189
dc.description.abstractConsidering the importance of hydantoin derivatives in treatment of status epilepticus, four 5-phenylhydantoins, whose lipophilicities were estimated to be similar to that of phenytoin, were synthesized. Evaluation of their anticonvulsant activities was performed on rats by subcutaneous pentylenetetrazol seizure test and intravenous pentylenetetrazol threshold test, and spontaneous locomotor activity test was used to assess possible sedative effects. X-ray analysis of three compounds suggested that certain analogies might be drawn between interactions in crystal packing and biological interactions responsible for their anticonvulsant activity. It was found that 5-ethyl-5-phenyl-3-propylhydantoin exhibits the most favorable pharmacological properties among the synthesized compounds, i.e., anticonvulsant activity comparable to phenytoin with lower liability for induction of sedation in rats.en
dc.publisherSpringer Wien, Wien
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172013/RS//
dc.rightsrestrictedAccess
dc.sourceMonatshefte Fur Chemie
dc.subjectHydantoin derivativesen
dc.subjectAnticonvulsant activityen
dc.subjectSedative effectsen
dc.subjectCrystal structureen
dc.titleSynthesis, structural and biological characterization of 5-phenylhydantoin derivatives as potential anticonvulsant agentsen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage1457
dc.citation.issue10
dc.citation.other143(10): 1451-1457
dc.citation.rankM22
dc.citation.spage1451
dc.citation.volume143
dc.identifier.doi10.1007/s00706-012-0791-8
dc.identifier.scopus2-s2.0-84867096117
dc.identifier.wos000309253500015
dc.type.versionpublishedVersion


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