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The Electrochemical Investigation of Inclusion Complexes of Nifedipine and Amlodipine with beta-Cyclodextrin and (2-Hydroxypropyl)-beta-Cyclodextrin

Authorized Users Only
2013
Authors
Stoiljković, Zora Ž.
Jovanović, Vladislava M.
Mijin, Dušan
Nikolić, V.
Nikolić, Ljubiša B.
Petrović, Slobodan
Avramov-Ivić, Milka
Article (Published version)
Metadata
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Abstract
The electrochemical behavior of inclusion complexes of nifedipine (Nif) and amlodipine (Aml), a long-acting calcium channel blockers dihydropyridine (DHP) class, with beta-cyclodextrin (beta CD) and (2-hydroxypropyl)-beta-cyclodextrin (HP beta CD), is examined using cyclic and square wave voltammetry in 0.05 M NaHCO3 and phosphate buffer (pH=11) on a gold electrode. The voltammograms show a single irreversible anodic wave with the current controlled by adsorption. It was found that phosphate buffer favorites the electrochemical activity of both complexes of Nif with the linear dependency of the oxidative currents on their concentrations. In phosphate buffer, only HP beta CD-Aml complex showed linear dependency of the oxidative currents on the concentration. In 0.05 M NaHCO3 as electrolyte only HP beta CD-Nif exhibited apparent activity. The initial potential of the anodic reaction as well as the value of the potential for anodic currents maximum of all the examined complexes in both el...ectrolytes were shifted to the positive direction compared to their standards. In addition, the value of anodic currents decreased.

Keywords:
cyclodextrin complexes / electrochemical determination / gold electrode / cyclic voltammetry / square wave voltammetry
Source:
International Journal of Electrochemical Science, 2013, 8, 7, 9543-9557
Publisher:
  • Electrochemical Science Group, Beograd
Funding / projects:
  • Study of the Synthesis, Structure and Activity of Natural and Synthetic Organic Compounds (RS-172013)

ISSN: 1452-3981

PubMed:

WoS: 000323547600055

Scopus: 2-s2.0-84881578068
[ Google Scholar ]
5
6
Handle
https://hdl.handle.net/21.15107/rcub_technorep_2259
URI
http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2259
Collections
  • Radovi istraživača / Researchers’ publications (TMF)
Institution/Community
Tehnološko-metalurški fakultet
TY  - JOUR
AU  - Stoiljković, Zora Ž.
AU  - Jovanović, Vladislava M.
AU  - Mijin, Dušan
AU  - Nikolić, V.
AU  - Nikolić, Ljubiša B.
AU  - Petrović, Slobodan
AU  - Avramov-Ivić, Milka
PY  - 2013
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2259
AB  - The electrochemical behavior of inclusion complexes of nifedipine (Nif) and amlodipine (Aml), a long-acting calcium channel blockers dihydropyridine (DHP) class, with beta-cyclodextrin (beta CD) and (2-hydroxypropyl)-beta-cyclodextrin (HP beta CD), is examined using cyclic and square wave voltammetry in 0.05 M NaHCO3 and phosphate buffer (pH=11) on a gold electrode. The voltammograms show a single irreversible anodic wave with the current controlled by adsorption. It was found that phosphate buffer favorites the electrochemical activity of both complexes of Nif with the linear dependency of the oxidative currents on their concentrations. In phosphate buffer, only HP beta CD-Aml complex showed linear dependency of the oxidative currents on the concentration. In 0.05 M NaHCO3 as electrolyte only HP beta CD-Nif exhibited apparent activity. The initial potential of the anodic reaction as well as the value of the potential for anodic currents maximum of all the examined complexes in both electrolytes were shifted to the positive direction compared to their standards. In addition, the value of anodic currents decreased.
PB  - Electrochemical Science Group, Beograd
T2  - International Journal of Electrochemical Science
T1  - The Electrochemical Investigation of Inclusion Complexes of Nifedipine and Amlodipine with beta-Cyclodextrin and (2-Hydroxypropyl)-beta-Cyclodextrin
EP  - 9557
IS  - 7
SP  - 9543
VL  - 8
UR  - https://hdl.handle.net/21.15107/rcub_technorep_2259
ER  - 
@article{
author = "Stoiljković, Zora Ž. and Jovanović, Vladislava M. and Mijin, Dušan and Nikolić, V. and Nikolić, Ljubiša B. and Petrović, Slobodan and Avramov-Ivić, Milka",
year = "2013",
abstract = "The electrochemical behavior of inclusion complexes of nifedipine (Nif) and amlodipine (Aml), a long-acting calcium channel blockers dihydropyridine (DHP) class, with beta-cyclodextrin (beta CD) and (2-hydroxypropyl)-beta-cyclodextrin (HP beta CD), is examined using cyclic and square wave voltammetry in 0.05 M NaHCO3 and phosphate buffer (pH=11) on a gold electrode. The voltammograms show a single irreversible anodic wave with the current controlled by adsorption. It was found that phosphate buffer favorites the electrochemical activity of both complexes of Nif with the linear dependency of the oxidative currents on their concentrations. In phosphate buffer, only HP beta CD-Aml complex showed linear dependency of the oxidative currents on the concentration. In 0.05 M NaHCO3 as electrolyte only HP beta CD-Nif exhibited apparent activity. The initial potential of the anodic reaction as well as the value of the potential for anodic currents maximum of all the examined complexes in both electrolytes were shifted to the positive direction compared to their standards. In addition, the value of anodic currents decreased.",
publisher = "Electrochemical Science Group, Beograd",
journal = "International Journal of Electrochemical Science",
title = "The Electrochemical Investigation of Inclusion Complexes of Nifedipine and Amlodipine with beta-Cyclodextrin and (2-Hydroxypropyl)-beta-Cyclodextrin",
pages = "9557-9543",
number = "7",
volume = "8",
url = "https://hdl.handle.net/21.15107/rcub_technorep_2259"
}
Stoiljković, Z. Ž., Jovanović, V. M., Mijin, D., Nikolić, V., Nikolić, L. B., Petrović, S.,& Avramov-Ivić, M.. (2013). The Electrochemical Investigation of Inclusion Complexes of Nifedipine and Amlodipine with beta-Cyclodextrin and (2-Hydroxypropyl)-beta-Cyclodextrin. in International Journal of Electrochemical Science
Electrochemical Science Group, Beograd., 8(7), 9543-9557.
https://hdl.handle.net/21.15107/rcub_technorep_2259
Stoiljković ZŽ, Jovanović VM, Mijin D, Nikolić V, Nikolić LB, Petrović S, Avramov-Ivić M. The Electrochemical Investigation of Inclusion Complexes of Nifedipine and Amlodipine with beta-Cyclodextrin and (2-Hydroxypropyl)-beta-Cyclodextrin. in International Journal of Electrochemical Science. 2013;8(7):9543-9557.
https://hdl.handle.net/21.15107/rcub_technorep_2259 .
Stoiljković, Zora Ž., Jovanović, Vladislava M., Mijin, Dušan, Nikolić, V., Nikolić, Ljubiša B., Petrović, Slobodan, Avramov-Ivić, Milka, "The Electrochemical Investigation of Inclusion Complexes of Nifedipine and Amlodipine with beta-Cyclodextrin and (2-Hydroxypropyl)-beta-Cyclodextrin" in International Journal of Electrochemical Science, 8, no. 7 (2013):9543-9557,
https://hdl.handle.net/21.15107/rcub_technorep_2259 .

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