The Electrochemical Investigation of Inclusion Complexes of Nifedipine and Amlodipine with beta-Cyclodextrin and (2-Hydroxypropyl)-beta-Cyclodextrin
Само за регистроване кориснике
2013
Аутори
Stoiljković, Zora Ž.Jovanović, Vladislava M.

Mijin, Dušan

Nikolić, V.
Nikolić, Ljubiša B.
Petrović, Slobodan
Avramov-Ivić, Milka

Чланак у часопису (Објављена верзија)

Метаподаци
Приказ свих података о документуАпстракт
The electrochemical behavior of inclusion complexes of nifedipine (Nif) and amlodipine (Aml), a long-acting calcium channel blockers dihydropyridine (DHP) class, with beta-cyclodextrin (beta CD) and (2-hydroxypropyl)-beta-cyclodextrin (HP beta CD), is examined using cyclic and square wave voltammetry in 0.05 M NaHCO3 and phosphate buffer (pH=11) on a gold electrode. The voltammograms show a single irreversible anodic wave with the current controlled by adsorption. It was found that phosphate buffer favorites the electrochemical activity of both complexes of Nif with the linear dependency of the oxidative currents on their concentrations. In phosphate buffer, only HP beta CD-Aml complex showed linear dependency of the oxidative currents on the concentration. In 0.05 M NaHCO3 as electrolyte only HP beta CD-Nif exhibited apparent activity. The initial potential of the anodic reaction as well as the value of the potential for anodic currents maximum of all the examined complexes in both el...ectrolytes were shifted to the positive direction compared to their standards. In addition, the value of anodic currents decreased.
Кључне речи:
cyclodextrin complexes / electrochemical determination / gold electrode / cyclic voltammetry / square wave voltammetryИзвор:
International Journal of Electrochemical Science, 2013, 8, 7, 9543-9557Издавач:
- Electrochemical Science Group, Beograd
Финансирање / пројекти:
- Проучавање синтезе, структуре и активности органских једињења природног и синтетског порекла (RS-172013)
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Stoiljković, Zora Ž. AU - Jovanović, Vladislava M. AU - Mijin, Dušan AU - Nikolić, V. AU - Nikolić, Ljubiša B. AU - Petrović, Slobodan AU - Avramov-Ivić, Milka PY - 2013 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2259 AB - The electrochemical behavior of inclusion complexes of nifedipine (Nif) and amlodipine (Aml), a long-acting calcium channel blockers dihydropyridine (DHP) class, with beta-cyclodextrin (beta CD) and (2-hydroxypropyl)-beta-cyclodextrin (HP beta CD), is examined using cyclic and square wave voltammetry in 0.05 M NaHCO3 and phosphate buffer (pH=11) on a gold electrode. The voltammograms show a single irreversible anodic wave with the current controlled by adsorption. It was found that phosphate buffer favorites the electrochemical activity of both complexes of Nif with the linear dependency of the oxidative currents on their concentrations. In phosphate buffer, only HP beta CD-Aml complex showed linear dependency of the oxidative currents on the concentration. In 0.05 M NaHCO3 as electrolyte only HP beta CD-Nif exhibited apparent activity. The initial potential of the anodic reaction as well as the value of the potential for anodic currents maximum of all the examined complexes in both electrolytes were shifted to the positive direction compared to their standards. In addition, the value of anodic currents decreased. PB - Electrochemical Science Group, Beograd T2 - International Journal of Electrochemical Science T1 - The Electrochemical Investigation of Inclusion Complexes of Nifedipine and Amlodipine with beta-Cyclodextrin and (2-Hydroxypropyl)-beta-Cyclodextrin EP - 9557 IS - 7 SP - 9543 VL - 8 UR - https://hdl.handle.net/21.15107/rcub_technorep_2259 ER -
@article{ author = "Stoiljković, Zora Ž. and Jovanović, Vladislava M. and Mijin, Dušan and Nikolić, V. and Nikolić, Ljubiša B. and Petrović, Slobodan and Avramov-Ivić, Milka", year = "2013", abstract = "The electrochemical behavior of inclusion complexes of nifedipine (Nif) and amlodipine (Aml), a long-acting calcium channel blockers dihydropyridine (DHP) class, with beta-cyclodextrin (beta CD) and (2-hydroxypropyl)-beta-cyclodextrin (HP beta CD), is examined using cyclic and square wave voltammetry in 0.05 M NaHCO3 and phosphate buffer (pH=11) on a gold electrode. The voltammograms show a single irreversible anodic wave with the current controlled by adsorption. It was found that phosphate buffer favorites the electrochemical activity of both complexes of Nif with the linear dependency of the oxidative currents on their concentrations. In phosphate buffer, only HP beta CD-Aml complex showed linear dependency of the oxidative currents on the concentration. In 0.05 M NaHCO3 as electrolyte only HP beta CD-Nif exhibited apparent activity. The initial potential of the anodic reaction as well as the value of the potential for anodic currents maximum of all the examined complexes in both electrolytes were shifted to the positive direction compared to their standards. In addition, the value of anodic currents decreased.", publisher = "Electrochemical Science Group, Beograd", journal = "International Journal of Electrochemical Science", title = "The Electrochemical Investigation of Inclusion Complexes of Nifedipine and Amlodipine with beta-Cyclodextrin and (2-Hydroxypropyl)-beta-Cyclodextrin", pages = "9557-9543", number = "7", volume = "8", url = "https://hdl.handle.net/21.15107/rcub_technorep_2259" }
Stoiljković, Z. Ž., Jovanović, V. M., Mijin, D., Nikolić, V., Nikolić, L. B., Petrović, S.,& Avramov-Ivić, M.. (2013). The Electrochemical Investigation of Inclusion Complexes of Nifedipine and Amlodipine with beta-Cyclodextrin and (2-Hydroxypropyl)-beta-Cyclodextrin. in International Journal of Electrochemical Science Electrochemical Science Group, Beograd., 8(7), 9543-9557. https://hdl.handle.net/21.15107/rcub_technorep_2259
Stoiljković ZŽ, Jovanović VM, Mijin D, Nikolić V, Nikolić LB, Petrović S, Avramov-Ivić M. The Electrochemical Investigation of Inclusion Complexes of Nifedipine and Amlodipine with beta-Cyclodextrin and (2-Hydroxypropyl)-beta-Cyclodextrin. in International Journal of Electrochemical Science. 2013;8(7):9543-9557. https://hdl.handle.net/21.15107/rcub_technorep_2259 .
Stoiljković, Zora Ž., Jovanović, Vladislava M., Mijin, Dušan, Nikolić, V., Nikolić, Ljubiša B., Petrović, Slobodan, Avramov-Ivić, Milka, "The Electrochemical Investigation of Inclusion Complexes of Nifedipine and Amlodipine with beta-Cyclodextrin and (2-Hydroxypropyl)-beta-Cyclodextrin" in International Journal of Electrochemical Science, 8, no. 7 (2013):9543-9557, https://hdl.handle.net/21.15107/rcub_technorep_2259 .