Приказ основних података о документу

dc.creatorPetrusić, Stojanka
dc.creatorJovančić, Petar
dc.creatorLewandowski, Maryline
dc.creatorGiraud, Stephane
dc.creatorGrujić, Svetlana
dc.creatorOstojić, Sanja
dc.creatorBugarski, Branko
dc.creatorKoncar, Vladan
dc.date.accessioned2021-03-10T12:06:37Z
dc.date.available2021-03-10T12:06:37Z
dc.date.issued2013
dc.identifier.issn0022-2461
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/2384
dc.description.abstractThis study highlights the advantages of functionalized poly(N-isopropylacrylamide) (PNIPAAm) microgels over pure PNIPAAm microgels in terms of polymer network properties and drug release profiles. PNIPAAm network was modified by addition of maleic anhydride (MA) as a comonomer and by formation of interpenetrating polymer network in the presence of alginate. The functionalized thermosensitive microgels in the size range from 20 to 80 mu m and with better performance in comparison with pure PNIPAAm microgels were prepared by inverse suspension polymerization. The impact of MA and alginate on the PNIPAAm microgel structure was evaluated through analysis of microgel size, size distribution, volume phase transition temperature (VPTT), equilibrium swelling ratio as well as morphology of the system. It was shown that the controlled modification of PNIPAAm network could result in microgels of considerably improved swelling capacity with unchanged thermosensitivity and maintained open pore morphology. In addition, drug release behavior of microgels could be markedly altered. Release of procaine hydrochloride from the selected microgels was studied using Franz diffusion cell at temperatures below and above VPTT of the microgels. Temperature-controlled drug release pattern was dependent on the type of functionalization of PNIPAAm network. According to drug loading properties and drug release mechanism, PNIPAAm/MA copolymer microgels demonstrated the optimal performances.en
dc.publisherSpringer, New York
dc.relationproject ARCUS 2006-Nord-Pas-de-Calais/Bulgarie-Roumanie-Serbie
dc.relationFrench Ministry of Foreign Affairs
dc.relationRegion Nord-Pas-De-CalaisRegion Hauts-de-France
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46010/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Materials Science
dc.titleProperties and drug release profile of poly(N-isopropylacrylamide) microgels functionalized with maleic anhydride and alginateen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage7948
dc.citation.issue22
dc.citation.other48(22): 7935-7948
dc.citation.rankM21
dc.citation.spage7935
dc.citation.volume48
dc.identifier.doi10.1007/s10853-013-7604-2
dc.identifier.scopus2-s2.0-84883196577
dc.identifier.wos000323503900019
dc.type.versionpublishedVersion


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Приказ основних података о документу