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dc.creatorObradović, Ana
dc.creatorZizić, Jovana
dc.creatorTrišović, Nemanja
dc.creatorBožić, Bojan
dc.creatorUšćumlić, Gordana
dc.creatorBožić, Biljana
dc.creatorMarković, Snežana
dc.date.accessioned2021-03-10T12:09:24Z
dc.date.available2021-03-10T12:09:24Z
dc.date.issued2013
dc.identifier.issn1300-0152
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/2427
dc.description.abstractAntioxidant effects of twelve 3-substituted-5,5-diphenylhydantoins in concentrations of 0.01, 0.1, 1, 10, and 100 mu M on human colon cancer cell line HCT-116 were determined 24 h after treatment. The concentrations of superoxide anion radical (O(2)radical anion), nitrites (NO2-), and total glutathione were determined spectrophotometrically. Results indicated that treatment with all compounds induced a decrease in O(2)radical anion and an increase in NO(2)(-)concentrations in HCT-116 cells. Treatment with all compounds resulted in an increase in glutathione, and this indicates changes in redox homeostasis. Based on the obtained results, the investigated hydantoins act as antioxidants because they decrease the production of superoxide anion radical and increase concentrations of glutathione, but they also induce an increase in nitrite production.en
dc.publisherTubitak Scientific & Technical Research Council Turkey, Ankara
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41010/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172013/RS//
dc.rightsopenAccess
dc.sourceTurkish Journal of Biology
dc.subjectAntioxidantsen
dc.subjectphenytoin derivativesen
dc.subjectfree radicalsen
dc.subjectredox homeostasisen
dc.titleEvaluation of antioxidative effects of twelve 3-substituted-5,5-diphenylhydantoins on human colon cancer cell line HCT-116en
dc.typearticle
dc.rights.licenseARR
dc.citation.epage747
dc.citation.issue6
dc.citation.other37(6): 741-747
dc.citation.rankM22
dc.citation.spage741
dc.citation.volume37
dc.identifier.doi10.3906/biy-1302-15
dc.identifier.fulltexthttp://TechnoRep.tmf.bg.ac.rs/bitstream/id/9833/10.3906-biy-1302-15-120977.pdf
dc.identifier.scopus2-s2.0-84885199159
dc.identifier.wos000325747400014
dc.type.versionpublishedVersion


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