RTD analysis of a novel Taylor-Couette flow device for blood detoxification
Само за регистроване кориснике
1999
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Heparin is an anticoagulant used in extracorporeal procedures such as hemodialysis and open heart surgery. Unfortunately: heparin may induce potentially fatal complications in patients at high risk of bleeding. The use of art immobilized heparinase I reactor makes heparin therapy safer; but the design of a safe and efficient reactor for medical use had been a significant problem. A novel reactor, based on simultaneous separation-reaction and Taylor-Couette flow, was designed and successfully tested in vitro with human blood and ex vivo in sleep. The objective of this study was to understand the flow dynamics in the reactor in order to predict and optimize heparin neutralization. Residence-time distribution studies were performed and a mathematical model was developed The model was able to predict experimental conversions within a mean relative error of 5.5%. Bypass flow through the reactive section was also predicted.
Извор:
AICHE Journal, 1999, 45, 3, 633-638Издавач:
- Amer Inst Chemical Engineers, New York
DOI: 10.1002/aic.690450320
ISSN: 0001-1541
WoS: 000079040700019
Scopus: 2-s2.0-0033103720
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Ameer, GA AU - Grovender, EA AU - Obradović, Bojana AU - Cooney, CL AU - Langer, R PY - 1999 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/248 AB - Heparin is an anticoagulant used in extracorporeal procedures such as hemodialysis and open heart surgery. Unfortunately: heparin may induce potentially fatal complications in patients at high risk of bleeding. The use of art immobilized heparinase I reactor makes heparin therapy safer; but the design of a safe and efficient reactor for medical use had been a significant problem. A novel reactor, based on simultaneous separation-reaction and Taylor-Couette flow, was designed and successfully tested in vitro with human blood and ex vivo in sleep. The objective of this study was to understand the flow dynamics in the reactor in order to predict and optimize heparin neutralization. Residence-time distribution studies were performed and a mathematical model was developed The model was able to predict experimental conversions within a mean relative error of 5.5%. Bypass flow through the reactive section was also predicted. PB - Amer Inst Chemical Engineers, New York T2 - AICHE Journal T1 - RTD analysis of a novel Taylor-Couette flow device for blood detoxification EP - 638 IS - 3 SP - 633 VL - 45 DO - 10.1002/aic.690450320 ER -
@article{ author = "Ameer, GA and Grovender, EA and Obradović, Bojana and Cooney, CL and Langer, R", year = "1999", abstract = "Heparin is an anticoagulant used in extracorporeal procedures such as hemodialysis and open heart surgery. Unfortunately: heparin may induce potentially fatal complications in patients at high risk of bleeding. The use of art immobilized heparinase I reactor makes heparin therapy safer; but the design of a safe and efficient reactor for medical use had been a significant problem. A novel reactor, based on simultaneous separation-reaction and Taylor-Couette flow, was designed and successfully tested in vitro with human blood and ex vivo in sleep. The objective of this study was to understand the flow dynamics in the reactor in order to predict and optimize heparin neutralization. Residence-time distribution studies were performed and a mathematical model was developed The model was able to predict experimental conversions within a mean relative error of 5.5%. Bypass flow through the reactive section was also predicted.", publisher = "Amer Inst Chemical Engineers, New York", journal = "AICHE Journal", title = "RTD analysis of a novel Taylor-Couette flow device for blood detoxification", pages = "638-633", number = "3", volume = "45", doi = "10.1002/aic.690450320" }
Ameer, G., Grovender, E., Obradović, B., Cooney, C.,& Langer, R.. (1999). RTD analysis of a novel Taylor-Couette flow device for blood detoxification. in AICHE Journal Amer Inst Chemical Engineers, New York., 45(3), 633-638. https://doi.org/10.1002/aic.690450320
Ameer G, Grovender E, Obradović B, Cooney C, Langer R. RTD analysis of a novel Taylor-Couette flow device for blood detoxification. in AICHE Journal. 1999;45(3):633-638. doi:10.1002/aic.690450320 .
Ameer, GA, Grovender, EA, Obradović, Bojana, Cooney, CL, Langer, R, "RTD analysis of a novel Taylor-Couette flow device for blood detoxification" in AICHE Journal, 45, no. 3 (1999):633-638, https://doi.org/10.1002/aic.690450320 . .