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Antimikrobni hidrogelovi na bazi 2-hidroksietil metakrilata i itakonske kiseline koji sadrže srebro(I) jon

dc.creatorMalešić, Neda B.
dc.creatorRusmirović, Jelena
dc.creatorJovašević, Jovana S.
dc.creatorPerišić, Marija D.
dc.creatorDimitrijević, Suzana
dc.creatorFilipović, Jovanka M.
dc.creatorTomić, Simonida
dc.date.accessioned2021-03-10T12:19:59Z
dc.date.available2021-03-10T12:19:59Z
dc.date.issued2014
dc.identifier.issn0040-2176
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/2595
dc.description.abstractThe objective of our study was to develop new antimicrobial hydrogels silver/poly(2-hydroxyethyl methacrylate/ itaconic acid) (Ag/P(HEMA/IA)). The P(HEMA/IA) samples, with different HEMA/IA ratio, were prepared by free radical crosslinking copolymerization. Ag ion were introduced in hydrogels by immersing dried P(HEMA/IA) disks in silver(I) salt solution, which was confirmed by FTIR spectroscopy. The in vitro controlled release of silver(I) ion from (Ag/P(HEMA/IA)) gels, and antimicrobial activity during the release period were also studied. The release profiles have shown a two-phase exponential profile, with fast initial phase, followed by a much slower release rate. Kinetic parameters determined, have indicated Fickian transport of Ag(I) ion in the initial phase. It is perceived that the antimicrobial activity of the Ag/P(HEMA/IA) depends on IA content. Excellent antimicrobial potential was maintained during the entire release time.en
dc.description.abstractCilj našeg istraživanja je bio da se razviju novi antimikrobni hidrogelovi. Srebro/poli(2-hidroksietil metakrilat/itakonska kiselina) (Ag/P(HEMA/IK)) hidrogelovi su sintetisani, i proučavano je kontrolisano otpuštanje srebro(I) jona iz Ag/P(HEMA/IK) hidrogelova, kao i njihov antimikrobni potencijal. P(HEMA/IK) uzorci, sa različitim odnosima monomera HEMA/IK, dobijeni su radikalnom kopolimerizacijom/ umrežavanjem. Ag/P(HEMA/IK) hidrogelovi su formirani potapanjem suvih diskova gelova u srebro(I) so, što je i potvrđeno FTIR spektroskopijom. Ispitani su kontrolisano otpuštanje srebro(I) jona iz Ag/P(HEMA/IA) gelova in vitro, kao i antimikrobna aktivnost tokom perioda otpuštanja. Profili otpuštanja su pokazali dve faze (eksponencijalni rast), sa brzom početnom fazom, a zatim sporijom brzinom otpuštanja. Antimikrobna aktivnost u toku otpuštanja u maloj meri zavisi od sadržaja IA i vremena otpuštanja. Odličan antimikrobni potencijal se održava tokom celog vremena otpuštanja. Na osnovu dobijenih rezultata proizilazi da se Ag/P(HEMA/IK) hidrogelovi mogu koristiti u širokom spektru biomedicinskih primena.sr
dc.publisherSavez inženjera i tehničara Srbije, Beograd
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172026/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172062/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceTehnika
dc.subject2-Hydroxyethyl methacrylateen
dc.subjectItaconic aciden
dc.subjectHydrogelen
dc.subjectSilver(I) ionen
dc.subjectControlled releaseen
dc.subjectAntimicrobial potentialen
dc.subject2-Hidroksietil metakrilatsr
dc.subjectitakonska kiselinasr
dc.subjecthidrogelsr
dc.subjectsrebro(I) jonsr
dc.subjectkontrolisanootpuštanjesr
dc.subjectantimikrobni potencijalsr
dc.titleAntimicrobial hydrogels based on 2-hydroxyethyl methacrylate and itaconic acid containing silver(I) ionen
dc.titleAntimikrobni hidrogelovi na bazi 2-hidroksietil metakrilata i itakonske kiseline koji sadrže srebro(I) jonsr
dc.typearticle
dc.rights.licenseBY
dc.citation.epage568
dc.citation.issue4
dc.citation.other69(4): 563-568
dc.citation.rankM51
dc.citation.spage563
dc.citation.volume69
dc.identifier.doi10.5937/tehnika1404563M
dc.identifier.fulltexthttp://TechnoRep.tmf.bg.ac.rs/bitstream/id/9123/0040-21761404563M.pdf
dc.identifier.rcubconv_40
dc.type.versionpublishedVersion


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