Chitosan microbeads for encapsulation of thyme (Thymus serpyllum L.) polyphenols
Само за регистроване кориснике
2014
Аутори
Trifković, Kata T.Milašinović, Nikola
Đorđević, Verica
Kalagasidis Krušić, Melina
Knežević-Jugović, Zorica
Nedović, Viktor
Bugarski, Branko
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
In this work chitosan microbeads were prepared by emulsion technique and loaded with thyme polyphenols by diffusion from an external aqueous solution of Thymus serpyllum L. The effects of concentrations of chitosan (1.5-3% (w/v)) and GA (glutaraldehyde) (0.1-0.4% (v/v)), as a crosslinking agent on the main properties of microbeads were assessed. The obtained microgel beads from similar to 220 to similar to 790 mu m in diameter were exposed to controlled drying process at air (at 37 degrees C) after which they contracted to irregular shapes (similar to 70-230 mu m). The loading of dried microbeads with polyphenols was achieved by swelling in the acidic medium. The swelling rate of microbeads decreased with the increase in GA concentration. Upon this rehydration, thyme polypheriols were effectively encapsulated (active load of 66-114mg GAEg(beads)(-1)) and the microbeads recovered a spherical shape. Both, the increase in the amount of the crosslinking agent and the presence of polyphenol...s, contributed to a more pronounced surface roughness of microbeads. The release of encapsulated polyphenols in simulated gastrointestinal fluids was prolonged to 3 h.
Кључне речи:
Emulsion crosslinking technique / Chitosan microbeads / Polyphenols / MicroencapsulationИзвор:
Carbohydrate Polymers, 2014, 111, 901-907Издавач:
- Elsevier Sci Ltd, Oxford
Финансирање / пројекти:
- Развој нових инкапсулационих и ензимских технологија за производњу биокатализатора и биолошки активних компонената хране у циљу повећања њене конкурентности, квалитета и безбедности (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46010)
- Синтеза и карактеризација нових функционалних полимера и полимерних нанокомпозита (RS-MESTD-Basic Research (BR or ON)-172062)
DOI: 10.1016/j.carbpol.2014.05.053
ISSN: 0144-8617
PubMed: 25037430
WoS: 000340302100109
Scopus: 2-s2.0-84902330332
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Trifković, Kata T. AU - Milašinović, Nikola AU - Đorđević, Verica AU - Kalagasidis Krušić, Melina AU - Knežević-Jugović, Zorica AU - Nedović, Viktor AU - Bugarski, Branko PY - 2014 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2647 AB - In this work chitosan microbeads were prepared by emulsion technique and loaded with thyme polyphenols by diffusion from an external aqueous solution of Thymus serpyllum L. The effects of concentrations of chitosan (1.5-3% (w/v)) and GA (glutaraldehyde) (0.1-0.4% (v/v)), as a crosslinking agent on the main properties of microbeads were assessed. The obtained microgel beads from similar to 220 to similar to 790 mu m in diameter were exposed to controlled drying process at air (at 37 degrees C) after which they contracted to irregular shapes (similar to 70-230 mu m). The loading of dried microbeads with polyphenols was achieved by swelling in the acidic medium. The swelling rate of microbeads decreased with the increase in GA concentration. Upon this rehydration, thyme polypheriols were effectively encapsulated (active load of 66-114mg GAEg(beads)(-1)) and the microbeads recovered a spherical shape. Both, the increase in the amount of the crosslinking agent and the presence of polyphenols, contributed to a more pronounced surface roughness of microbeads. The release of encapsulated polyphenols in simulated gastrointestinal fluids was prolonged to 3 h. PB - Elsevier Sci Ltd, Oxford T2 - Carbohydrate Polymers T1 - Chitosan microbeads for encapsulation of thyme (Thymus serpyllum L.) polyphenols EP - 907 SP - 901 VL - 111 DO - 10.1016/j.carbpol.2014.05.053 ER -
@article{ author = "Trifković, Kata T. and Milašinović, Nikola and Đorđević, Verica and Kalagasidis Krušić, Melina and Knežević-Jugović, Zorica and Nedović, Viktor and Bugarski, Branko", year = "2014", abstract = "In this work chitosan microbeads were prepared by emulsion technique and loaded with thyme polyphenols by diffusion from an external aqueous solution of Thymus serpyllum L. The effects of concentrations of chitosan (1.5-3% (w/v)) and GA (glutaraldehyde) (0.1-0.4% (v/v)), as a crosslinking agent on the main properties of microbeads were assessed. The obtained microgel beads from similar to 220 to similar to 790 mu m in diameter were exposed to controlled drying process at air (at 37 degrees C) after which they contracted to irregular shapes (similar to 70-230 mu m). The loading of dried microbeads with polyphenols was achieved by swelling in the acidic medium. The swelling rate of microbeads decreased with the increase in GA concentration. Upon this rehydration, thyme polypheriols were effectively encapsulated (active load of 66-114mg GAEg(beads)(-1)) and the microbeads recovered a spherical shape. Both, the increase in the amount of the crosslinking agent and the presence of polyphenols, contributed to a more pronounced surface roughness of microbeads. The release of encapsulated polyphenols in simulated gastrointestinal fluids was prolonged to 3 h.", publisher = "Elsevier Sci Ltd, Oxford", journal = "Carbohydrate Polymers", title = "Chitosan microbeads for encapsulation of thyme (Thymus serpyllum L.) polyphenols", pages = "907-901", volume = "111", doi = "10.1016/j.carbpol.2014.05.053" }
Trifković, K. T., Milašinović, N., Đorđević, V., Kalagasidis Krušić, M., Knežević-Jugović, Z., Nedović, V.,& Bugarski, B.. (2014). Chitosan microbeads for encapsulation of thyme (Thymus serpyllum L.) polyphenols. in Carbohydrate Polymers Elsevier Sci Ltd, Oxford., 111, 901-907. https://doi.org/10.1016/j.carbpol.2014.05.053
Trifković KT, Milašinović N, Đorđević V, Kalagasidis Krušić M, Knežević-Jugović Z, Nedović V, Bugarski B. Chitosan microbeads for encapsulation of thyme (Thymus serpyllum L.) polyphenols. in Carbohydrate Polymers. 2014;111:901-907. doi:10.1016/j.carbpol.2014.05.053 .
Trifković, Kata T., Milašinović, Nikola, Đorđević, Verica, Kalagasidis Krušić, Melina, Knežević-Jugović, Zorica, Nedović, Viktor, Bugarski, Branko, "Chitosan microbeads for encapsulation of thyme (Thymus serpyllum L.) polyphenols" in Carbohydrate Polymers, 111 (2014):901-907, https://doi.org/10.1016/j.carbpol.2014.05.053 . .