Cardiovascular Drugs in Environmental Waters and Wastewaters: Method Optimization and Real Sample Analysis
Samo za registrovane korisnike
2014
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
A sensitive method for determination of the eight most prescribed drugs used in combined cardiovascular therapy in Serbia was developed and optimized. The method was based on SPE followed by LC/ion trap-MS/MS with positive electrospray ionization. Parameters that affect the SPE were optimized, such as the eluent, sample pH, and sample volume. Good recoveries from groundwater (87.6-120.9%) as well as wastewater (84.5-106.6%) were achieved with this method, except in the case of atorvastatin (26.1 and 45.2%, respectively). The method was applied in the analysis of four river water samples collected in Serbia, as well as nine corresponding groundwater samples. Residues of the beta-blockers metoprolol and bisoprolol as well as the anticoagulant clopidogrel were detected for the first time in river water. Groundwater samples did not contain drug residues. Influents and effluents of two wastewater treatment plants showed the predominant presence of metoprolol and enalapril. The removal rate ...of metoprolol was generally low, whereas enalapril was eliminated with the highest efficiency. Atorvastatin was detected in influents and completely removed in the treatment.
Izvor:
Journal of AOAC International, 2014, 97, 4, 1167-1174Izdavač:
- Aoac Int, Gaithersburg
Finansiranje / projekti:
DOI: 10.5740/jaoacint.12-121
ISSN: 1060-3271
PubMed: 25145153
WoS: 000339537800030
Scopus: 2-s2.0-84905396381
Institucija/grupa
Tehnološko-metalurški fakultetTY - JOUR AU - Jauković, Zorica D. AU - Grujić, Svetlana AU - Vasiljević, Tatjana AU - Petrović, Slobodan AU - Laušević, Mila PY - 2014 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2672 AB - A sensitive method for determination of the eight most prescribed drugs used in combined cardiovascular therapy in Serbia was developed and optimized. The method was based on SPE followed by LC/ion trap-MS/MS with positive electrospray ionization. Parameters that affect the SPE were optimized, such as the eluent, sample pH, and sample volume. Good recoveries from groundwater (87.6-120.9%) as well as wastewater (84.5-106.6%) were achieved with this method, except in the case of atorvastatin (26.1 and 45.2%, respectively). The method was applied in the analysis of four river water samples collected in Serbia, as well as nine corresponding groundwater samples. Residues of the beta-blockers metoprolol and bisoprolol as well as the anticoagulant clopidogrel were detected for the first time in river water. Groundwater samples did not contain drug residues. Influents and effluents of two wastewater treatment plants showed the predominant presence of metoprolol and enalapril. The removal rate of metoprolol was generally low, whereas enalapril was eliminated with the highest efficiency. Atorvastatin was detected in influents and completely removed in the treatment. PB - Aoac Int, Gaithersburg T2 - Journal of AOAC International T1 - Cardiovascular Drugs in Environmental Waters and Wastewaters: Method Optimization and Real Sample Analysis EP - 1174 IS - 4 SP - 1167 VL - 97 DO - 10.5740/jaoacint.12-121 ER -
@article{ author = "Jauković, Zorica D. and Grujić, Svetlana and Vasiljević, Tatjana and Petrović, Slobodan and Laušević, Mila", year = "2014", abstract = "A sensitive method for determination of the eight most prescribed drugs used in combined cardiovascular therapy in Serbia was developed and optimized. The method was based on SPE followed by LC/ion trap-MS/MS with positive electrospray ionization. Parameters that affect the SPE were optimized, such as the eluent, sample pH, and sample volume. Good recoveries from groundwater (87.6-120.9%) as well as wastewater (84.5-106.6%) were achieved with this method, except in the case of atorvastatin (26.1 and 45.2%, respectively). The method was applied in the analysis of four river water samples collected in Serbia, as well as nine corresponding groundwater samples. Residues of the beta-blockers metoprolol and bisoprolol as well as the anticoagulant clopidogrel were detected for the first time in river water. Groundwater samples did not contain drug residues. Influents and effluents of two wastewater treatment plants showed the predominant presence of metoprolol and enalapril. The removal rate of metoprolol was generally low, whereas enalapril was eliminated with the highest efficiency. Atorvastatin was detected in influents and completely removed in the treatment.", publisher = "Aoac Int, Gaithersburg", journal = "Journal of AOAC International", title = "Cardiovascular Drugs in Environmental Waters and Wastewaters: Method Optimization and Real Sample Analysis", pages = "1174-1167", number = "4", volume = "97", doi = "10.5740/jaoacint.12-121" }
Jauković, Z. D., Grujić, S., Vasiljević, T., Petrović, S.,& Laušević, M.. (2014). Cardiovascular Drugs in Environmental Waters and Wastewaters: Method Optimization and Real Sample Analysis. in Journal of AOAC International Aoac Int, Gaithersburg., 97(4), 1167-1174. https://doi.org/10.5740/jaoacint.12-121
Jauković ZD, Grujić S, Vasiljević T, Petrović S, Laušević M. Cardiovascular Drugs in Environmental Waters and Wastewaters: Method Optimization and Real Sample Analysis. in Journal of AOAC International. 2014;97(4):1167-1174. doi:10.5740/jaoacint.12-121 .
Jauković, Zorica D., Grujić, Svetlana, Vasiljević, Tatjana, Petrović, Slobodan, Laušević, Mila, "Cardiovascular Drugs in Environmental Waters and Wastewaters: Method Optimization and Real Sample Analysis" in Journal of AOAC International, 97, no. 4 (2014):1167-1174, https://doi.org/10.5740/jaoacint.12-121 . .