Modeling analysis of the lipid bilayer-cytoskeleton coupling in erythrocyte membrane
Abstract
Studies of thermal fluctuations in discocytes, echinocytes, and spherocytes suggest that the coupling between lipid bilayer and cytoskeleton can affect viscoelastic behavior of single erythrocyte membranes. To test this hypothesis, we developed a 3D constitutive model describing viscoelastic behavior of erythrocyte membranes, at long relaxation times and short relaxation times . The model was constructed using combination of spring and spring pot rheological elements arranged in parallel. The rearrangement of cytoskeleton induced by changing the bending state of lipid bilayer was described by a modified Eyring model. The model predictions point to an anomalous nature of energy dissipation and an ordered harmonic nature of the coupling mechanism described by a series of fractional derivatives of the order n (where ). As a result, the stress generated within the lipid bilayer is related to the rate of change of the irreversible stress within the cytoskeleton.
Keywords:
Coupling mechanism / Viscoelasticity / Membrane / Modeling / Damping effectsSource:
Biomechanics and Modeling in Mechanobiology, 2014, 13, 5, 1097-1104Publisher:
- Springer Heidelberg, Heidelberg
Funding / projects:
- Develooment and utilization of novel and traditional technologies in production of competitive food products with added valued for national and global market - CREATING WEALTH FROM THE WEALTH OF SERBIA (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46001)
- Novel encapsulation and enzyme technologies for designing of new biocatalysts and biologically active compounds targeting enhancement of food quality, safety and competitiveness (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46010)
DOI: 10.1007/s10237-014-0559-7
ISSN: 1617-7959
PubMed: 24535085
WoS: 000341782900013
Scopus: 2-s2.0-84893735296
Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Pajić-Lijaković, Ivana AU - Milivojević, Milan PY - 2014 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2679 AB - Studies of thermal fluctuations in discocytes, echinocytes, and spherocytes suggest that the coupling between lipid bilayer and cytoskeleton can affect viscoelastic behavior of single erythrocyte membranes. To test this hypothesis, we developed a 3D constitutive model describing viscoelastic behavior of erythrocyte membranes, at long relaxation times and short relaxation times . The model was constructed using combination of spring and spring pot rheological elements arranged in parallel. The rearrangement of cytoskeleton induced by changing the bending state of lipid bilayer was described by a modified Eyring model. The model predictions point to an anomalous nature of energy dissipation and an ordered harmonic nature of the coupling mechanism described by a series of fractional derivatives of the order n (where ). As a result, the stress generated within the lipid bilayer is related to the rate of change of the irreversible stress within the cytoskeleton. PB - Springer Heidelberg, Heidelberg T2 - Biomechanics and Modeling in Mechanobiology T1 - Modeling analysis of the lipid bilayer-cytoskeleton coupling in erythrocyte membrane EP - 1104 IS - 5 SP - 1097 VL - 13 DO - 10.1007/s10237-014-0559-7 ER -
@article{ author = "Pajić-Lijaković, Ivana and Milivojević, Milan", year = "2014", abstract = "Studies of thermal fluctuations in discocytes, echinocytes, and spherocytes suggest that the coupling between lipid bilayer and cytoskeleton can affect viscoelastic behavior of single erythrocyte membranes. To test this hypothesis, we developed a 3D constitutive model describing viscoelastic behavior of erythrocyte membranes, at long relaxation times and short relaxation times . The model was constructed using combination of spring and spring pot rheological elements arranged in parallel. The rearrangement of cytoskeleton induced by changing the bending state of lipid bilayer was described by a modified Eyring model. The model predictions point to an anomalous nature of energy dissipation and an ordered harmonic nature of the coupling mechanism described by a series of fractional derivatives of the order n (where ). As a result, the stress generated within the lipid bilayer is related to the rate of change of the irreversible stress within the cytoskeleton.", publisher = "Springer Heidelberg, Heidelberg", journal = "Biomechanics and Modeling in Mechanobiology", title = "Modeling analysis of the lipid bilayer-cytoskeleton coupling in erythrocyte membrane", pages = "1104-1097", number = "5", volume = "13", doi = "10.1007/s10237-014-0559-7" }
Pajić-Lijaković, I.,& Milivojević, M.. (2014). Modeling analysis of the lipid bilayer-cytoskeleton coupling in erythrocyte membrane. in Biomechanics and Modeling in Mechanobiology Springer Heidelberg, Heidelberg., 13(5), 1097-1104. https://doi.org/10.1007/s10237-014-0559-7
Pajić-Lijaković I, Milivojević M. Modeling analysis of the lipid bilayer-cytoskeleton coupling in erythrocyte membrane. in Biomechanics and Modeling in Mechanobiology. 2014;13(5):1097-1104. doi:10.1007/s10237-014-0559-7 .
Pajić-Lijaković, Ivana, Milivojević, Milan, "Modeling analysis of the lipid bilayer-cytoskeleton coupling in erythrocyte membrane" in Biomechanics and Modeling in Mechanobiology, 13, no. 5 (2014):1097-1104, https://doi.org/10.1007/s10237-014-0559-7 . .