Novel Bioactive Antimicrobial Lignin Containing Coatings on Titanium Obtained by Electrophoretic Deposition
Authors
Eraković, Sanja
Janković, Ana

Tsui, Gary C. P.

Tang, C. Y.

Mišković-Stanković, Vesna

Stevanović, Tatjana
Article (Published version)
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Show full item recordAbstract
Hydroxyapatite (HAP) is the most suitable biocompatible material for bone implant coatings; its brittleness, however, is a major obstacle, and the reason why research focuses on creating composites with biopolymers. Organosolv lignin (Lig) is used for the production of composite coatings, and these composites were examined in this study. Titanium substrate is a key biomedical material due to its well-known properties, but infections of the implantation site still impose a serious threat. One approach to prevent infection is to improve antimicrobial properties of the coating material. Silver doped hydroxyapatite (Ag/HAP) and HAP coatings on titanium were obtained by an electrophoretic deposition method in order to control deposited coating mass and morphology by varying applied voltage and deposition time. The effect of lignin on microstructure, morphology and thermal behavior of biocomposite coatings was investigated. The results showed that higher lignin concentrations protect the HAP... lattice during sintering, improving coating stability. The corrosion stability was evaluated in simulated body fluid (SBF) at 37 degrees C. Newly formed plate-shaped carbonate-HAP was detected, indicating enhanced bioactive performance. The antimicrobial efficiency of Ag/HAP/Lig was confirmed by its higher reduction of bacteria Staphylococcus aureus TL (S. aureus TL) than of HAP/Lig coating. Cytotoxicity assay revealed that both coatings can be classified as non-toxic against healthy immunocompetent peripheral blood mononuclear cells (PBMC).
Keywords:
organosolv lignin / silver / hydroxyapatite / electrophoretic deposition / titanium / bioactivity / SBF / cytotoxicity / antimicrobial activitySource:
International Journal of Molecular Sciences, 2014, 15, 7, 12294-12322Publisher:
- MDPI, Basel
Funding / projects:
- Synthesis, processing and applications of nanostructured multifunctional materials with defined properties (RS-45019)
- National Sciences and Engineering Research Council of Canada (NSERC)Natural Sciences and Engineering Research Council of Canada
DOI: 10.3390/ijms150712294
ISSN: 1422-0067
PubMed: 25019343
WoS: 000340038500069
Scopus: 2-s2.0-84904211855
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Tehnološko-metalurški fakultetTY - JOUR AU - Eraković, Sanja AU - Janković, Ana AU - Tsui, Gary C. P. AU - Tang, C. Y. AU - Mišković-Stanković, Vesna AU - Stevanović, Tatjana PY - 2014 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2694 AB - Hydroxyapatite (HAP) is the most suitable biocompatible material for bone implant coatings; its brittleness, however, is a major obstacle, and the reason why research focuses on creating composites with biopolymers. Organosolv lignin (Lig) is used for the production of composite coatings, and these composites were examined in this study. Titanium substrate is a key biomedical material due to its well-known properties, but infections of the implantation site still impose a serious threat. One approach to prevent infection is to improve antimicrobial properties of the coating material. Silver doped hydroxyapatite (Ag/HAP) and HAP coatings on titanium were obtained by an electrophoretic deposition method in order to control deposited coating mass and morphology by varying applied voltage and deposition time. The effect of lignin on microstructure, morphology and thermal behavior of biocomposite coatings was investigated. The results showed that higher lignin concentrations protect the HAP lattice during sintering, improving coating stability. The corrosion stability was evaluated in simulated body fluid (SBF) at 37 degrees C. Newly formed plate-shaped carbonate-HAP was detected, indicating enhanced bioactive performance. The antimicrobial efficiency of Ag/HAP/Lig was confirmed by its higher reduction of bacteria Staphylococcus aureus TL (S. aureus TL) than of HAP/Lig coating. Cytotoxicity assay revealed that both coatings can be classified as non-toxic against healthy immunocompetent peripheral blood mononuclear cells (PBMC). PB - MDPI, Basel T2 - International Journal of Molecular Sciences T1 - Novel Bioactive Antimicrobial Lignin Containing Coatings on Titanium Obtained by Electrophoretic Deposition EP - 12322 IS - 7 SP - 12294 VL - 15 DO - 10.3390/ijms150712294 ER -
@article{ author = "Eraković, Sanja and Janković, Ana and Tsui, Gary C. P. and Tang, C. Y. and Mišković-Stanković, Vesna and Stevanović, Tatjana", year = "2014", abstract = "Hydroxyapatite (HAP) is the most suitable biocompatible material for bone implant coatings; its brittleness, however, is a major obstacle, and the reason why research focuses on creating composites with biopolymers. Organosolv lignin (Lig) is used for the production of composite coatings, and these composites were examined in this study. Titanium substrate is a key biomedical material due to its well-known properties, but infections of the implantation site still impose a serious threat. One approach to prevent infection is to improve antimicrobial properties of the coating material. Silver doped hydroxyapatite (Ag/HAP) and HAP coatings on titanium were obtained by an electrophoretic deposition method in order to control deposited coating mass and morphology by varying applied voltage and deposition time. The effect of lignin on microstructure, morphology and thermal behavior of biocomposite coatings was investigated. The results showed that higher lignin concentrations protect the HAP lattice during sintering, improving coating stability. The corrosion stability was evaluated in simulated body fluid (SBF) at 37 degrees C. Newly formed plate-shaped carbonate-HAP was detected, indicating enhanced bioactive performance. The antimicrobial efficiency of Ag/HAP/Lig was confirmed by its higher reduction of bacteria Staphylococcus aureus TL (S. aureus TL) than of HAP/Lig coating. Cytotoxicity assay revealed that both coatings can be classified as non-toxic against healthy immunocompetent peripheral blood mononuclear cells (PBMC).", publisher = "MDPI, Basel", journal = "International Journal of Molecular Sciences", title = "Novel Bioactive Antimicrobial Lignin Containing Coatings on Titanium Obtained by Electrophoretic Deposition", pages = "12322-12294", number = "7", volume = "15", doi = "10.3390/ijms150712294" }
Eraković, S., Janković, A., Tsui, G. C. P., Tang, C. Y., Mišković-Stanković, V.,& Stevanović, T.. (2014). Novel Bioactive Antimicrobial Lignin Containing Coatings on Titanium Obtained by Electrophoretic Deposition. in International Journal of Molecular Sciences MDPI, Basel., 15(7), 12294-12322. https://doi.org/10.3390/ijms150712294
Eraković S, Janković A, Tsui GCP, Tang CY, Mišković-Stanković V, Stevanović T. Novel Bioactive Antimicrobial Lignin Containing Coatings on Titanium Obtained by Electrophoretic Deposition. in International Journal of Molecular Sciences. 2014;15(7):12294-12322. doi:10.3390/ijms150712294 .
Eraković, Sanja, Janković, Ana, Tsui, Gary C. P., Tang, C. Y., Mišković-Stanković, Vesna, Stevanović, Tatjana, "Novel Bioactive Antimicrobial Lignin Containing Coatings on Titanium Obtained by Electrophoretic Deposition" in International Journal of Molecular Sciences, 15, no. 7 (2014):12294-12322, https://doi.org/10.3390/ijms150712294 . .