Hydroxyapatite (HAP) is the most suitable biocompatible material for bone implant coatings; its brittleness, however, is a major obstacle, and the reason why research focuses on creating composites with biopolymers. Organosolv lignin (Lig) is used for the production of composite coatings, and these composites were examined in this study. Titanium substrate is a key biomedical material due to its well-known properties, but infections of the implantation site still impose a serious threat. One approach to prevent infection is to improve antimicrobial properties of the coating material. Silver doped hydroxyapatite (Ag/HAP) and HAP coatings on titanium were obtained by an electrophoretic deposition method in order to control deposited coating mass and morphology by varying applied voltage and deposition time. The effect of lignin on microstructure, morphology and thermal behavior of biocomposite coatings was investigated. The results showed that higher lignin concentrations protect the HAP... lattice during sintering, improving coating stability. The corrosion stability was evaluated in simulated body fluid (SBF) at 37 degrees C. Newly formed plate-shaped carbonate-HAP was detected, indicating enhanced bioactive performance. The antimicrobial efficiency of Ag/HAP/Lig was confirmed by its higher reduction of bacteria Staphylococcus aureus TL (S. aureus TL) than of HAP/Lig coating. Cytotoxicity assay revealed that both coatings can be classified as non-toxic against healthy immunocompetent peripheral blood mononuclear cells (PBMC).
TY - JOUR
AU - Eraković, Sanja
AU - Janković, Ana
AU - Tsui, Gary C. P.
AU - Tang, C. Y.
AU - Mišković-Stanković, Vesna
AU - Stevanović, Tatjana
PY - 2014
UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2694
AB - Hydroxyapatite (HAP) is the most suitable biocompatible material for bone implant coatings; its brittleness, however, is a major obstacle, and the reason why research focuses on creating composites with biopolymers. Organosolv lignin (Lig) is used for the production of composite coatings, and these composites were examined in this study. Titanium substrate is a key biomedical material due to its well-known properties, but infections of the implantation site still impose a serious threat. One approach to prevent infection is to improve antimicrobial properties of the coating material. Silver doped hydroxyapatite (Ag/HAP) and HAP coatings on titanium were obtained by an electrophoretic deposition method in order to control deposited coating mass and morphology by varying applied voltage and deposition time. The effect of lignin on microstructure, morphology and thermal behavior of biocomposite coatings was investigated. The results showed that higher lignin concentrations protect the HAP lattice during sintering, improving coating stability. The corrosion stability was evaluated in simulated body fluid (SBF) at 37 degrees C. Newly formed plate-shaped carbonate-HAP was detected, indicating enhanced bioactive performance. The antimicrobial efficiency of Ag/HAP/Lig was confirmed by its higher reduction of bacteria Staphylococcus aureus TL (S. aureus TL) than of HAP/Lig coating. Cytotoxicity assay revealed that both coatings can be classified as non-toxic against healthy immunocompetent peripheral blood mononuclear cells (PBMC).
PB - MDPI, Basel
T2 - International Journal of Molecular Sciences
T1 - Novel Bioactive Antimicrobial Lignin Containing Coatings on Titanium Obtained by Electrophoretic Deposition
EP - 12322
IS - 7
SP - 12294
VL - 15
DO - 10.3390/ijms150712294
ER -
@article{
author = "Eraković, Sanja and Janković, Ana and Tsui, Gary C. P. and Tang, C. Y. and Mišković-Stanković, Vesna and Stevanović, Tatjana",
year = "2014",
abstract = "Hydroxyapatite (HAP) is the most suitable biocompatible material for bone implant coatings; its brittleness, however, is a major obstacle, and the reason why research focuses on creating composites with biopolymers. Organosolv lignin (Lig) is used for the production of composite coatings, and these composites were examined in this study. Titanium substrate is a key biomedical material due to its well-known properties, but infections of the implantation site still impose a serious threat. One approach to prevent infection is to improve antimicrobial properties of the coating material. Silver doped hydroxyapatite (Ag/HAP) and HAP coatings on titanium were obtained by an electrophoretic deposition method in order to control deposited coating mass and morphology by varying applied voltage and deposition time. The effect of lignin on microstructure, morphology and thermal behavior of biocomposite coatings was investigated. The results showed that higher lignin concentrations protect the HAP lattice during sintering, improving coating stability. The corrosion stability was evaluated in simulated body fluid (SBF) at 37 degrees C. Newly formed plate-shaped carbonate-HAP was detected, indicating enhanced bioactive performance. The antimicrobial efficiency of Ag/HAP/Lig was confirmed by its higher reduction of bacteria Staphylococcus aureus TL (S. aureus TL) than of HAP/Lig coating. Cytotoxicity assay revealed that both coatings can be classified as non-toxic against healthy immunocompetent peripheral blood mononuclear cells (PBMC).",
publisher = "MDPI, Basel",
journal = "International Journal of Molecular Sciences",
title = "Novel Bioactive Antimicrobial Lignin Containing Coatings on Titanium Obtained by Electrophoretic Deposition",
pages = "12322-12294",
number = "7",
volume = "15",
doi = "10.3390/ijms150712294"
}
Eraković, S., Janković, A., Tsui, G. C. P., Tang, C. Y., Mišković-Stanković, V.,& Stevanović, T.. (2014). Novel Bioactive Antimicrobial Lignin Containing Coatings on Titanium Obtained by Electrophoretic Deposition. in International Journal of Molecular Sciences
MDPI, Basel., 15(7), 12294-12322.
https://doi.org/10.3390/ijms150712294
Eraković S, Janković A, Tsui GCP, Tang CY, Mišković-Stanković V, Stevanović T. Novel Bioactive Antimicrobial Lignin Containing Coatings on Titanium Obtained by Electrophoretic Deposition. in International Journal of Molecular Sciences. 2014;15(7):12294-12322.
doi:10.3390/ijms150712294 .
Eraković, Sanja, Janković, Ana, Tsui, Gary C. P., Tang, C. Y., Mišković-Stanković, Vesna, Stevanović, Tatjana, "Novel Bioactive Antimicrobial Lignin Containing Coatings on Titanium Obtained by Electrophoretic Deposition" in International Journal of Molecular Sciences, 15, no. 7 (2014):12294-12322,
https://doi.org/10.3390/ijms150712294 . .
