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pH-Sensitive Hydrogels Based on (Meth)Acrylates and Itaconic Acid

Authorized Users Only
2014
Authors
Tomić, Simonida
Babić, Marija
Antić, Katarina
Jovašević-Vuković, Jovana J.
Malešić, Neda B.
Filipović, Jovanka M.
Article (Published version)
Metadata
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Abstract
Novel hydrogels based on 2-hydroxyethyl methacrylate (HEMA), itaconic acid (IA) and different poly (alkylene glycol) (meth)acrylates (PAGM) (P(HEMA/IA/PAGM)) were synthesized. We investigated the influence of different PAGM components, with acrylic or methacrylic acid residues in the main chain and ethylene glycol (EG) and/or propylene glycol (PG) units in pendant chains of varying length, on the nature and inherent properties of P(HEMA/IA/PAGM) copolymeric hydrogels. Swelling studies revealed pH sensitive behavior of P(HEMA/IA/PAGM) samples. Hydrogel structure and morphology were characterized by Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM), which confirmed their chemical structure and differences in pore size. The shear modulus values for P(HEMA/IA/PAGM) hydrogels were close to that of PHEMA, but slightly lower than the value for P(HEMA/IA). Cephalexin (CEX) drug release profiles from P(HEMA/IA/PAGM) samples showed a marked dependence on the P...AGM component. The presence of IA also influenced the release rate of CEX, leading to a faster release when IA was combined with the more hydrophilic PAGM component. An in vitro assay of P(HEMA/IA/PAGM) cytotoxicity showed good cell viability. The results obtained indicate that P(HEMA/IA/PAGM) hydrogel properties were significantly dependent on the PAGM component, meaning that the type of side chains can be used to tune the characteristics of such biomaterials. These properties make P(HEMA/IA/PAGM) copolymeric hydrogels applicable in biomedical and biotechnological fields and controlled drug delivery.

Keywords:
2-hydroxyethyl methacrylate / itaconic acid / poly(alkylene glycol) (meth)acrylates / morphology / mechanical and thermal properties / pH-sensitive swelling / controlled drug release / cytotoxicity
Source:
Macromolecular Research, 2014, 22, 11, 1203-1213
Publisher:
  • Polymer Soc Korea, Seoul
Funding / projects:
  • Chemical and structural designing of nanomaterials for application in medicine and tissue engineering (RS-172026)
  • Synthesis and characterization of novel functional polymers and polymeric nanocomposites (RS-172062)

DOI: 10.1007/s13233-014-2172-0

ISSN: 1598-5032

WoS: 000345397100011

Scopus: 2-s2.0-84912125858
[ Google Scholar ]
17
12
URI
http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2719
Collections
  • Radovi istraživača / Researchers’ publications (TMF)
  • Radovi istraživača (Inovacioni centar) / Researchers’ publications (Innovation Centre)
Institution/Community
Tehnološko-metalurški fakultet
TY  - JOUR
AU  - Tomić, Simonida
AU  - Babić, Marija
AU  - Antić, Katarina
AU  - Jovašević-Vuković, Jovana J.
AU  - Malešić, Neda B.
AU  - Filipović, Jovanka M.
PY  - 2014
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2719
AB  - Novel hydrogels based on 2-hydroxyethyl methacrylate (HEMA), itaconic acid (IA) and different poly (alkylene glycol) (meth)acrylates (PAGM) (P(HEMA/IA/PAGM)) were synthesized. We investigated the influence of different PAGM components, with acrylic or methacrylic acid residues in the main chain and ethylene glycol (EG) and/or propylene glycol (PG) units in pendant chains of varying length, on the nature and inherent properties of P(HEMA/IA/PAGM) copolymeric hydrogels. Swelling studies revealed pH sensitive behavior of P(HEMA/IA/PAGM) samples. Hydrogel structure and morphology were characterized by Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM), which confirmed their chemical structure and differences in pore size. The shear modulus values for P(HEMA/IA/PAGM) hydrogels were close to that of PHEMA, but slightly lower than the value for P(HEMA/IA). Cephalexin (CEX) drug release profiles from P(HEMA/IA/PAGM) samples showed a marked dependence on the PAGM component. The presence of IA also influenced the release rate of CEX, leading to a faster release when IA was combined with the more hydrophilic PAGM component. An in vitro assay of P(HEMA/IA/PAGM) cytotoxicity showed good cell viability. The results obtained indicate that P(HEMA/IA/PAGM) hydrogel properties were significantly dependent on the PAGM component, meaning that the type of side chains can be used to tune the characteristics of such biomaterials. These properties make P(HEMA/IA/PAGM) copolymeric hydrogels applicable in biomedical and biotechnological fields and controlled drug delivery.
PB  - Polymer Soc Korea, Seoul
T2  - Macromolecular Research
T1  - pH-Sensitive Hydrogels Based on (Meth)Acrylates and Itaconic Acid
EP  - 1213
IS  - 11
SP  - 1203
VL  - 22
DO  - 10.1007/s13233-014-2172-0
ER  - 
@article{
author = "Tomić, Simonida and Babić, Marija and Antić, Katarina and Jovašević-Vuković, Jovana J. and Malešić, Neda B. and Filipović, Jovanka M.",
year = "2014",
abstract = "Novel hydrogels based on 2-hydroxyethyl methacrylate (HEMA), itaconic acid (IA) and different poly (alkylene glycol) (meth)acrylates (PAGM) (P(HEMA/IA/PAGM)) were synthesized. We investigated the influence of different PAGM components, with acrylic or methacrylic acid residues in the main chain and ethylene glycol (EG) and/or propylene glycol (PG) units in pendant chains of varying length, on the nature and inherent properties of P(HEMA/IA/PAGM) copolymeric hydrogels. Swelling studies revealed pH sensitive behavior of P(HEMA/IA/PAGM) samples. Hydrogel structure and morphology were characterized by Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM), which confirmed their chemical structure and differences in pore size. The shear modulus values for P(HEMA/IA/PAGM) hydrogels were close to that of PHEMA, but slightly lower than the value for P(HEMA/IA). Cephalexin (CEX) drug release profiles from P(HEMA/IA/PAGM) samples showed a marked dependence on the PAGM component. The presence of IA also influenced the release rate of CEX, leading to a faster release when IA was combined with the more hydrophilic PAGM component. An in vitro assay of P(HEMA/IA/PAGM) cytotoxicity showed good cell viability. The results obtained indicate that P(HEMA/IA/PAGM) hydrogel properties were significantly dependent on the PAGM component, meaning that the type of side chains can be used to tune the characteristics of such biomaterials. These properties make P(HEMA/IA/PAGM) copolymeric hydrogels applicable in biomedical and biotechnological fields and controlled drug delivery.",
publisher = "Polymer Soc Korea, Seoul",
journal = "Macromolecular Research",
title = "pH-Sensitive Hydrogels Based on (Meth)Acrylates and Itaconic Acid",
pages = "1213-1203",
number = "11",
volume = "22",
doi = "10.1007/s13233-014-2172-0"
}
Tomić, S., Babić, M., Antić, K., Jovašević-Vuković, J. J., Malešić, N. B.,& Filipović, J. M.. (2014). pH-Sensitive Hydrogels Based on (Meth)Acrylates and Itaconic Acid. in Macromolecular Research
Polymer Soc Korea, Seoul., 22(11), 1203-1213.
https://doi.org/10.1007/s13233-014-2172-0
Tomić S, Babić M, Antić K, Jovašević-Vuković JJ, Malešić NB, Filipović JM. pH-Sensitive Hydrogels Based on (Meth)Acrylates and Itaconic Acid. in Macromolecular Research. 2014;22(11):1203-1213.
doi:10.1007/s13233-014-2172-0 .
Tomić, Simonida, Babić, Marija, Antić, Katarina, Jovašević-Vuković, Jovana J., Malešić, Neda B., Filipović, Jovanka M., "pH-Sensitive Hydrogels Based on (Meth)Acrylates and Itaconic Acid" in Macromolecular Research, 22, no. 11 (2014):1203-1213,
https://doi.org/10.1007/s13233-014-2172-0 . .

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