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dc.creatorTomić, Simonida
dc.creatorBabić, Marija
dc.creatorAntić, Katarina
dc.creatorJovašević-Vuković, Jovana J.
dc.creatorMalešić, Neda B.
dc.creatorFilipović, Jovanka M.
dc.date.accessioned2021-03-10T12:27:46Z
dc.date.available2021-03-10T12:27:46Z
dc.date.issued2014
dc.identifier.issn1598-5032
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/2719
dc.description.abstractNovel hydrogels based on 2-hydroxyethyl methacrylate (HEMA), itaconic acid (IA) and different poly (alkylene glycol) (meth)acrylates (PAGM) (P(HEMA/IA/PAGM)) were synthesized. We investigated the influence of different PAGM components, with acrylic or methacrylic acid residues in the main chain and ethylene glycol (EG) and/or propylene glycol (PG) units in pendant chains of varying length, on the nature and inherent properties of P(HEMA/IA/PAGM) copolymeric hydrogels. Swelling studies revealed pH sensitive behavior of P(HEMA/IA/PAGM) samples. Hydrogel structure and morphology were characterized by Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM), which confirmed their chemical structure and differences in pore size. The shear modulus values for P(HEMA/IA/PAGM) hydrogels were close to that of PHEMA, but slightly lower than the value for P(HEMA/IA). Cephalexin (CEX) drug release profiles from P(HEMA/IA/PAGM) samples showed a marked dependence on the PAGM component. The presence of IA also influenced the release rate of CEX, leading to a faster release when IA was combined with the more hydrophilic PAGM component. An in vitro assay of P(HEMA/IA/PAGM) cytotoxicity showed good cell viability. The results obtained indicate that P(HEMA/IA/PAGM) hydrogel properties were significantly dependent on the PAGM component, meaning that the type of side chains can be used to tune the characteristics of such biomaterials. These properties make P(HEMA/IA/PAGM) copolymeric hydrogels applicable in biomedical and biotechnological fields and controlled drug delivery.en
dc.publisherPolymer Soc Korea, Seoul
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172026/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172062/RS//
dc.rightsrestrictedAccess
dc.sourceMacromolecular Research
dc.subject2-hydroxyethyl methacrylateen
dc.subjectitaconic aciden
dc.subjectpoly(alkylene glycol) (meth)acrylatesen
dc.subjectmorphologyen
dc.subjectmechanical and thermal propertiesen
dc.subjectpH-sensitive swellingen
dc.subjectcontrolled drug releaseen
dc.subjectcytotoxicityen
dc.titlepH-Sensitive Hydrogels Based on (Meth)Acrylates and Itaconic Aciden
dc.typearticle
dc.rights.licenseARR
dc.citation.epage1213
dc.citation.issue11
dc.citation.other22(11): 1203-1213
dc.citation.rankM22
dc.citation.spage1203
dc.citation.volume22
dc.identifier.doi10.1007/s13233-014-2172-0
dc.identifier.scopus2-s2.0-84912125858
dc.identifier.wos000345397100011
dc.type.versionpublishedVersion


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