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dc.creatorMilivojević, Ana
dc.creatorStojanović, Marija
dc.creatorCarević, Milica
dc.creatorMihailović, Mladen
dc.creatorVeličković, Dušan
dc.creatorMilosavić, Nenad
dc.creatorBezbradica, Dejan
dc.date.accessioned2021-03-10T12:29:19Z
dc.date.available2021-03-10T12:29:19Z
dc.date.issued2014
dc.identifier.issn0888-5885
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/2744
dc.description.abstractLipase-catalyzed acylation of phloridzin with a wide range of fatty acids and antioxidant activities of synthesized esters were investigated in this study. Polar solvents were suitable reaction media for esterification, and the highest yield was achieved in acetonitrile. By using statistically designed optimization of key experimental factors for the synthesis of phloridzil oleate as the model reaction, great improvements in achieved conversion and yield per enzyme mass were enabled. The most significant progress has been made in the cost-effectiveness of the reaction, since the specific yield of 5.45 mmol g(-1) was obtained at 58 degrees C, with 0.09 M phloridzin, 1.17 M oleic acid, and only 0.5% (w/v) biocatalyst. All examined fatty acids were suitable acyl donors, since the chain length and unsaturation degree had slight effects on esterification and all products yielded over 70%. Phloridzil caprate, myristate, and oleate exhibited the highest antioxidant activities among the obtained esters.en
dc.publisherAmer Chemical Soc, Washington
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46010/RS//
dc.rightsrestrictedAccess
dc.sourceIndustrial & Engineering Chemistry Research
dc.titleLipase-Catalyzed Esterification of Phloridzin: Acyl Donor Effect on Enzymatic Affinity and Antioxidant Properties of Estersen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage16651
dc.citation.issue43
dc.citation.other53(43): 16644-16651
dc.citation.rankM21
dc.citation.spage16644
dc.citation.volume53
dc.identifier.doi10.1021/ie5027259
dc.identifier.scopus2-s2.0-84908565425
dc.identifier.wos000344042700006
dc.type.versionpublishedVersion


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