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dc.creatorStanić, Vojislav
dc.creatorDimitrijević, Suzana
dc.creatorAntonović, Dušan
dc.creatorJokić, Bojan
dc.creatorZec, Slavica
dc.creatorTanasković, Slađana
dc.creatorRaičević, Slavica
dc.date.accessioned2021-03-10T12:30:05Z
dc.date.available2021-03-10T12:30:05Z
dc.date.issued2014
dc.identifier.issn0169-4332
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/2756
dc.description.abstractSynthetic biomaterials based on fluorine substituted hydroxyapatite are potentially attractive for orthopedic and dental implant applications. The new synthesis of fluorine substituted hydroxyapatite samples were done by neutralization, which consists of adding the solution of HF and H3PO4 in suspension of Ca(OH)(2). Characterization studies from XRD, SEM and FTIR spectra showed that crystals are obtained with apatite structure and those particles of all samples are nano size, with an average length of 80 nm and about 15-25 nm in diameter. The central composite design was used in order to determine the optimal conditions for the antimicrobial activity of the synthesized samples. In order to evaluate the influence of operating parameters on the percent of viable cell reduction of Streptococcus mutans, three independent variables were chosen: exposure time, pH of saline and floride concentration in apatite samples. The experimental and predicted antimicrobial activities were in close agreement. Antimicrobial activity of the samples increases with the increase of fluoride concentration and the decreased pH of saline. The maximum antimicrobial activity was achieved at the initial pH of 4.en
dc.publisherElsevier Science Bv, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/43009/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/31035/RS//
dc.rightsrestrictedAccess
dc.sourceApplied Surface Science
dc.subjectFluoroapatiteen
dc.subjectBiomaterialsen
dc.subjectAntimicrobialen
dc.subjectStreptococcus mutansen
dc.subjectCariessen
dc.titleSynthesis of fluorine substituted hydroxyapatite nanopowders and application of the central composite design for determination of its antimicrobial effectsen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage352
dc.citation.other290: 346-352
dc.citation.rankM21
dc.citation.spage346
dc.citation.volume290
dc.identifier.doi10.1016/j.apsusc.2013.11.081
dc.identifier.rcubconv_4297
dc.identifier.scopus2-s2.0-84891028891
dc.identifier.wos000329060100052
dc.type.versionpublishedVersion


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